215 research outputs found
Influence of charge asymmetry and isospin dependent cross-section on elliptical flow
Using the isospin dependent quantum molecular dynamics model, we study the
effect of charge asymmetry and isospin dependent cross-section on different
aspects of elliptical flow. Simulations have been carried out for the reactions
of , where m = (47, 50, 53, 57 and 59) and
, where n= (14, 16, 18, 21 and 23). Our study shows that
elliptical flow depend strongly on the isospin of cross-section. The transition
energy remains almost constant with increase in N/Z of the system. A good
agreement is obtained with experimental measurements
Design, synthesis and anticonvulsant activity of some new 6,8-halo-substituted-2H-[1,2,4]triazino[5,6-b]indole-3(5H)-one/-thione and 6,8-halo-substituted 5-methyl-2H-[1,2,4]triazino[5,6-b]indol-3(5H)-one/-thione
A new series of 6,8-halo-substituted-2H-[1,2,4]triazino[5,6-b]indole-3(5H)-one/-thione and
6,8-halo-substituted 5-methyl-2H-[1,2,4]triazino[5,6-b]indol-3(5H)-one/-thione (5a-5l) were designed and synthesized keeping in view of the structural
requirement of pharmacophore. The above compounds were characterized by thin layer chromatography and spectral analysis. Anticonvulsant activity of the synthesized compounds was evaluated by the maximal electroshock (MES) test. Neurotoxicity and CNS depressant effects were evaluated by the rotarod motor impairment and Porsolt’s force swim tests, respectively. A computational study was carried out, for calculation of pharmacophore pattern, prediction of pharmacokinetic properties and toxicity properties. The above study revealed that the compounds 8-chloro-2H-[1,2,4]triazino[5,6-b]indol-3(5H)-one (5e), 6,8-dibromo-2H-[1,2,4]triazino[5,6-b]indol-3(5H)-one (5i) and 6,8-dibromo-5-methyl-2H-[1,2,4]triazino[5,6-b]indol-3(5H)-one (5k) possess excellent anticonvulsant activity in the series with little CNS depressant effect and no neurotoxicity as compared to standard drugs phenytoin and carbamazepine
Can slow roll inflation induce relevant helical magnetic fields?
We study the generation of helical magnetic fields during single field
inflation induced by an axial coupling of the electromagnetic field to the
inflaton. During slow roll inflation, we find that such a coupling always leads
to a blue spectrum with , as long as the theory is treated
perturbatively. The magnetic energy density at the end of inflation is found to
be typically too small to backreact on the background dynamics of the inflaton.
We also show that a short deviation from slow roll does not result in strong
modifications to the shape of the spectrum. We calculate the evolution of the
correlation length and the field amplitude during the inverse cascade and
viscous damping of the helical magnetic field in the radiation era after
inflation. We conclude that except for low scale inflation with very strong
coupling, the magnetic fields generated by such an axial coupling in single
field slow roll inflation with perturbative coupling to the inflaton are too
weak to provide the seeds for the observed fields in galaxies and clusters.Comment: 33 pages 6 figures; v4 to match the accepted version to appear in
JCA
Comparative analysis of expressed sequence tags (ESTs) between drought-tolerant and -susceptible genotypes of chickpea under terminal drought stress
<p>Abstract</p> <p>Background</p> <p>Chickpea (<it>Cicer arietinum </it>L.) is an important grain-legume crop that is mainly grown in rainfed areas, where terminal drought is a major constraint to its productivity. We generated expressed sequence tags (ESTs) by suppression subtraction hybridization (SSH) to identify differentially expressed genes in drought-tolerant and -susceptible genotypes in chickpea.</p> <p>Results</p> <p>EST libraries were generated by SSH from root and shoot tissues of IC4958 (drought tolerant) and ICC 1882 (drought resistant) exposed to terminal drought conditions by the dry down method. SSH libraries were also constructed by using 2 sets of bulks prepared from the RNA of root tissues from selected recombinant inbred lines (RILs) (10 each) for the extreme high and low root biomass phenotype. A total of 3062 unigenes (638 contigs and 2424 singletons), 51.4% of which were novel in chickpea, were derived by cluster assembly and sequence alignment of 5949 ESTs. Only 2185 (71%) unigenes showed significant BLASTX similarity (<1E-06) in the NCBI non-redundant (nr) database. Gene ontology functional classification terms (BLASTX results and GO term), were retrieved for 2006 (92.0%) sequences, and 656 sequences were further annotated with 812 Enzyme Commission (EC) codes and were mapped to 108 different KEGG pathways. In addition, expression status of 830 unigenes in response to terminal drought stress was evaluated using macro-array (dot blots). The expression of few selected genes was validated by northern blotting and quantitative real-time PCR assay.</p> <p>Conclusion</p> <p>Our study compares not only genes that are up- and down-regulated in a drought-tolerant genotype under terminal drought stress and a drought susceptible genotype but also between the bulks of the selected RILs exhibiting extreme phenotypes. More than 50% of the genes identified have been shown to be associated with drought stress in chickpea for the first time. This study not only serves as resource for marker discovery, but can provide a better insight into the selection of candidate genes (both up- and downregulated) associated with drought tolerance. These results can be used to identify suitable targets for manipulating the drought-tolerance trait in chickpea.</p
On the evolution of tachyonic perturbations at super-Hubble scales
In the slow-roll inflationary scenario, the amplitude of the curvature
perturbations approaches a constant value soon after the modes leave the Hubble
radius. However, relatively recently, it was shown that the amplitude of the
curvature perturbations induced by the canonical scalar field can grow at
super-Hubble scales if there is either a transition to fast roll inflation or
if inflation is interrupted for some period of time. In this work, we extend
the earlier analysis to the case of a non-canonical scalar field described by
the Dirac-Born-Infeld action. With the help of a specific example, we show that
the amplitude of the tachyonic perturbations can be enhanced or suppressed at
super-Hubble scales if there is a transition from slow roll to fast roll
inflation. We also illustrate as to how the growth of the entropy perturbations
during the fast roll regime proves to be responsible for the change in the
amplitude of the curvature perturbations at super-Hubble scales. Furthermore,
following the earlier analysis for the canonical scalar field, we show that the
power spectrum evaluated in the long wavelength approximation matches the exact
power spectrum obtained numerically very well. Finally, we briefly comment on
an application of this phenomenon.Comment: v1: 15 pages, 4 figures; v2: 16 pages, 5 figures, power spectrum
included, discussion in section 5 enlarged, references added; v3: 17 pages, 5
figures, enhancement AS WELL AS suppression of modes at super-Hubble scales
pointed out, title changed, discussions enlarged, references added, to appear
in JCA
Disk-Jet Connection in Cygnus X-3
We present the results of a detailed correlation study between the soft
X-ray, hard X-ray, and radio emission (obtained from RXTE ASM, BATSE, and GBI
observations, respectively) of the bright radio emitting Galactic X-ray binary
Cygnus X-3. We detect a very strong positive correlation between the soft X-ray
and radio emission during the low-hard and minor flaring periods of the source,
and an anti-correlation between the soft and hard X-ray emissions. We present
statistical arguments to suggest that the anti-correlation between the radio
and hard X-ray emission, reported earlier, is primarily due to their
correlation and anti-correlation, respectively, with the soft X-ray emission.
We make a wide band X-ray spectral study using the pointed RXTE observations
and detect a pivotal behaviour in the X-ray spectrum. We argue that this X-ray
spectral pivoting is responsible for the anti-correlation between the soft and
hard X-ray emissions. The strong correlation between the soft X-ray and radio
emission suggests a close link between the accreting mechanism, plasma cloud
surrounding the compact object and the radio emission.Comment: Accepted in A&A Letters. Major revioson of discussion, minor revision
of tables and figure
Correlation of myocardial strain by CMR-feature tracking with substrate abnormalities detected by electro-anatomical mapping in patients with nonischemic cardiomyopathy
Genomic-enabled prediction models using multi-environment trials to estimate the effect of genotype × environment interaction on prediction accuracy in chickpea
Genomic selection (GS) by selecting lines prior to field phenotyping using genotyping data has the potential to enhance the rate of genetic gains. Genotype × environment (G × E) interaction inclusion in GS models can improve prediction accuracy hence aid in selection of lines across target environments. Phenotypic data on 320 chickpea breeding lines for eight traits for three seasons at two locations were recorded. These lines were genotyped using DArTseq (1.6 K SNPs) and Genotyping-by-Sequencing (GBS; 89 K SNPs). Thirteen models were fitted including main effects of environment and lines, markers, and/or naïve and informed interactions to estimate prediction accuracies. Three cross-validation schemes mimicking real scenarios that breeders might encounter in the fields were considered to assess prediction accuracy of the models (CV2: incomplete field trials or sparse testing; CV1: newly developed lines; and CV0: untested environments). Maximum prediction accuracies for different traits and different models were observed with CV2. DArTseq performed better than GBS and the combined genotyping set (DArTseq and GBS) regardless of the cross validation scheme with most of the main effect marker and interaction models. Improvement of GS models and application of various genotyping platforms are key factors for obtaining accurate and precise prediction accuracies, leading to more precise selection of candidates
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