Frobenius splitting and ordinarity

We examine the relationship between the notion of Frobenius splitting and ordinarity for varieties. We show that the de Rham-Witt cohomology groups Hi(X,W(OX)) of a smooth projective Frobenius split variety are finitely generated over W(k). We provide counterexamples to a conjecture of Mehta that Frobenius split varieties are ordinary or even Hodge-Witt

Clinicopathological study of testicular lesions

Background: Testis is affected by both neoplastic and non neoplastic conditions. Non neoplastic lesions of the testis include epididymo-orchitis, testicular atrophy, undescended testis, testicular abscess etc. Testicular tumors are relatively rare. They constitute the 4th most common cause of death from neoplasia in the young males. This study was undertaken to study the histopathological spectrum, age wise distribution and clinical symptoms of testicular lesions.Methods: This is a retrospective study of three years conducted in the department of pathology, Aurangabad from June 2015 to May 2018. It included all the orchidectomy specimens received from the department of surgery and excluded the orchidectomy specimens sent for infertility and prostatic carcinoma. A detail clinical history was taken. Histopathological examination was done after routine processing and staining with H and E. The data collected was tabulated, analysed and compared to other similar studies.Results: We studied 70 cases. Non neoplastic testicular lesions were 57 and 13 were neoplastic. Non neoplastic testicular lesions were more common than the neoplastic ones. Non neoplastic testicular lesions presented most commonly in the 2nd decade. Most common non neoplastic lesion was epididymo-orchitis followed by torsion, atrophy and testicular abscess. Most common neoplasm was malignant mixed germ cell tumor. Most of the patients of neoplasms presented in the 3rd decade. The most common complaint was testicular swelling and pain.Conclusions: Majority of testicular lesions are non neoplastic. Neoplastic lesions are rare. Non neoplastic lesions mimic neoplastic ones clinically, as testicular swelling is the most common complaint. So histopathological diagnosis is necessary for an accurate diagnosis of testicular lesions

Depth-wise variations of soil physicochemical properties in the apple growing area of Mustang district, Nepal

Understanding the soil fertility is an important management tool in assessing the nutrient requirement of the crops. Considering this, a study was done to determine depth-wise soil parameters distribution in the apple growing areas of Gharpajhog Rural Municipality, Mustang during October 2019. The total 68 sampling points were selected randomly in the different sites, and collection was done from three depths viz. 0-20cm, 20-40cm and 40-60cm by using soil sampling auger. The soil separates, pH, organic matter, total N, available P2O5 and K2O were determined following standard methods in National Soil Science Research Centre, Khumaltar. The results of the study revealed that the effect of depth was significant in the sand and silt proportion, while non- significant in clay proportion. The highest (40.17±1.57%) sand content was in 40-60cm depth, meanwhile highest (45.64±1.07%) silt content was in surface (0-20cm) depth. In addition to this, soil pH, OM, total N, available P2O5 and K2O were also affected by the depth. The highest (8.27) pH was determined in the lower (40-60cm) depth. On the other hand, highest OM (4.93±0.2%), total N (0.24±0.01%), available P2O5 (43.47±4.35 mg/kg) and available K2O (95.91±5.8 mg/kg) in surface (0.20 cm) depth. The surface depth possessed strong content of studied soil parameters might be due to in-situ incorporation of leaf litter, residue etc. as well as applied manure in the surface. Finally, we can also conclude that the adopted current nutrient management practice should be continued for apple production in the study area

Clinicopathological study of skin tumours

Background: Skin cancers are relatively uncommon malignancies worldwide, but the incidence of skin cancers has progressively increased over the last few decades. The distinction between benign and malignant neoplasm are more difficult to define when they appear in skin than when found elsewhere and histopathological examination is frequently required to establish a definitive diagnosis. Diagnosis of any skin tumours can be done by correlating clinical features and histological features. The aim and objective were to study age-sex wise distribution, clinical presentation and histopathological spectrum of various skin tumours.Methods: This is a retrospective study of three years conducted in the Department of Pathology, Government Medical College, Aurangabad, India from December 2015 to December 2018. Specimens received from Department of Dermatology were fixed in formalin and after adequately processing the sections were stained routinely with H and E stain and properly evaluated for histopathological examination. This study includes tumors of epidermis along with melanogenic tumors and skin appendageal tumors. The data collected was tabulated, analysed and compared to other similar studies.Results: The study consists of 130 cases. The ratio of male to female was 1.24:1. Head and neck region (48.46%) was the most common site observed where skin lesions were present followed by extremities (37.69%). Most of the malignant tumours were presented with non-healing ulcers (30.76%) and Noduloulcerative lesions (20.33%). Out of 130 cases, 83 (63.84%) were benign whereas 47 (36.15%) were malignant tumour. According to WHO classification, keratinocytic tumour 55 (42.30%) was the most common tumour type in the present study. Skin adnexal tumours and melanocytic tumours were observed in 54 (41.53%) and 21 (16.15%) respectively.Conclusions: The skin is a complex organ. Because of complexity of skin, a wide range of diseases can develop from the skin. The majority of benign neoplasms are from skin adnexal group whereas most common malignant neoplasm were from keratinocytic group. Skin adnexal tumors can occur anywhere in the body, however head and neck region constitute the most common site. Skin adnexal tumours are clinically often misdiagnosed, so histopathological examination remains gold standard for their correct diagnosis and for their differentiation between benign and malignant neoplasm

Niemann-pick disease type A-a case report

Niemann-Pick Disease is an autosomal recessive disorder of infancy, characterized by failure to thrive, hepatosplenomegaly and neurodegenerative changes. It is caused by inherited deficiency of an enzyme, acid sphingomyelinase. It leads to deposition of sphingomyelin and cholesterol within the lysosome of reticuloendothelial cells of various organs. Niemann-Pick Disease is classified into four types such as A, B, C and D. We present a case of niemann-pick disease type A. This case report encompasses an 18-month-old male child brought with complaints of progressive abdominal distension, developmental delay, intermittent fever and excessive cry. On examination patient had developmental delay and significant abdominal distension with moderate hepatosplenomegaly. Bone marrow examination showed characteristic lipid laden foamy histiocytes termed as niemann pick cells and sea blue histiocytes. Later on, liver biopsy and splenic aspiration cytology was performed, which also showed same type of foamy cells. Type A is very rare and a severe infantile form with neurologic degeneration resulting in death usually by 3 years of age. No treatment available for type A so far. It’s a rare disease in India. Genetic counseling.

Determination of Maximum Recommended Weight Limit for Manual Lifting Task in Industry through Taguchi Parametric Optimization Technique

In this paper Authors have tried to calculate the maximum Recommended Weight Limit (RWL) for manual lifting task in industry on the basis of revised Load constant (LC), Horizontal Multiplier (HM), Vertical Multiplier (VM), which are calculated according to the collected data from industry. The purpose of this paper is to efficiently determine the optimum combination of those three factors to achieve the maximum recommended weight limit. In the order to meet the purpose in term of Recommended Weight Limit (RWL), author has applied the taguchi parametric optimization technique. The base of this study is NIOSH lifting equation, in this equation the recommended weight is calculated by the multiplication of seven factors, authors have worked only three factors i.e. LC, HM, VM respectively

A Comparative Study Between Pneumatic and Laser Lithotripsy for Proximal Ureteric Calculus

Introduction: There are various modalities of breaking urinary tract calculus. The aim of this study was to compare outcome between laser and pneumatic lithotripsy in patients with upper ureteric calculus in terms of stone free rate, proximal migration and complication. Methods: This was a prospective comparative study done in 210 patients with upper ureteric calculus. The patients were randomized into two groups (Laser Lithotripsy and Pneumatic Lithotripsy) from April 2018 to June 2019. The main objective of both the procedures was to break stone into particles less than 3 mm which was confirmed by X-ray KUB and ultrasonography of abdomen and pelvis after six weeks and to compare effectiveness in terms of immediate stone free rate, proximal migration, operative duration and post-operative complication. Results: There was no difference in age, gender and stone size in both groups. Immediate stone free rate was 99.05% in Laser Lithotripsy and 76.19% in Pneumatic Lithotripsy (p value<0.001). Proximal migration in Laser Lithotripsy was 0.95% and 23.81% in Pneumatic Lithotripsy (p<0.001). There was significantly prolonged operative duration in Pneumatic Lithotripsy (14.7±4.77 min vs 13.31±3.24 in Laser Lithotripsy, p=0.014). Complications were more in Pneumatic Lithotripsy group, which was statistically significant (p=0.017). Conclusion: Both pneumatic and laser lithotripsy are effective and safe modalities for treating upper ureteric calculus, however laser has less chances of proximal migration and higher immediate stone free rate with less complicatio

Conservation Agriculture for Food Security and Climate Resilience in Nepal

Achieving the sustainable development goals of the United Nations requires innovations in agriculture and development of climate-smart and economically feasible approaches for smallholder farmers in developing countries. Historical climate data of Nepal, which include 116 yr since 1901, has shown an increasing trend for average temperature by 0.016 ˚C yr–1 whereas precipitation has shown a decreasing trend by 0.137 mm yr–1. Such weather trends could enhance glacier melt associated flooding, and delayed monsoon rainfalls negatively impacting the agricultural production. The Nepalese government is promoting conservation agriculture (CA) through development of low-cost technologies that can be used effectively in difficult terrains. Such techniques include crop diversification, crop rotation, cover crops, and minimum tillage; all of which can reduce soil degradation. In addition, increasing crop residue retention can result in greater C sequestration and crop yield and reductions in greenhouse gas emissions. However, there is still lack of consensus on the merits of CA in the context of smallholder farming systems in Nepal. This paper reviews existing literature and provides an overview of farming practices in Nepal, highlights near-term challenges associated with climate change and food security, and discusses the role of CA as a climate-smart strategy to minimize soil degradation and improve food security

Spectrum of hemoglobinopathies by high performance liquid chromatography with special reference to role of HbA2 levels at tertiary care centre

Background: The inherited disorders of blood include hemoglobinopathies as one of the major public health problems in India. This study indicates type of hemoglobinopathies in a tertiary care hospital over period of 2 years and 3 months.Methods: total of 500 suspected cases of haemolytic anaemia were studied during the period of July 2013 to Oct 2015 based on Complete Blood Count, Red cell indices and Peripheral blood smear examination. Sickling test, test for Hb quantitation by using cation exchange HPLC was done in all cases.Results: Out of all 500 cases of anaemia, 313 cases (62.6%) were confirmed to nonhemolytic anaemia whereas 187 cases (37.4%) had shown abnormal haemoglobin pattern on electrophoresis. Out of these 187 cases, 87 (46.52%) were Males and 100 (53.48%) were females. Most common haemoglobinopathy observed was Sickle cell trait 94 (18.8%) followed by beta-Thalassaemia Trait 33 (17.64%), sickle cell-thalassemia trait 27 (14.43%), beta thalassemia major 18 (9.62%) and 1 case of HbE thalassemia trait. The onset of disease was most prominent in Neonatal to paediatric age group (0-10 years) followed by reproductive age group (21-30 years). Few cases in old age were detected.Conclusions: Study provides data on the spectrum & pattern of Hemoglobinopathies in a tertiary care centre and importance of HbA2 levels in diagnosis of hemoglobinopathies and cases falling in borderline HbA2 levels. Screening of all anaemic patients should be done for Hemoglobinopathies and proper Genetic counselling must be given to all cases to prevent incidence of cases in future generation