Numerical Computational Technique for Scattering from Underwater Objects

This paper presents a computational technique for mono-static and bi-static scattering from underwater objects of different shape such as submarines. The scatter has been computed using finite element time domain (FETD) method, based on the superposition of reflections, from the different elements reaching the receiver at a particular instant in time. The results calculated by this method has been verified with the published results based on ramp response technique. An in-depth parametric study has been carried out, by considering different pulse frequency, pulse length, pulse type (CW, LFM , SFM), sampling frequency, as well as different size , shape of the scatteringbody and grid size. It has been observed that increasing the pulse frequency, sampling frequency and number of elements leads to improved results. However, good amount of accuracy has been achieved with element size less than one third of wave length. The experimental result of the underwater object has been found very close to the`simulated result. This technique is useful for computing forward scatter for inverse scattering applications and as well as to generate forward scatter of very narrow and wide band signals of any pulse type and shape of body.Defence Science Journal, 2013, 63(1), pp.119-126, DOI:http://dx.doi.org/10.14429/dsj.63.77

Indigenous Ways of Knowing in Nepal: Exploring Indigenous Research Procedures in Shamanism

By presenting Shamanism as a form and tradition of indigenous knowledge, this paper aims to reduce the uncertainties attached to the concept in common approaches to indigenous research. Most indigenist researchers, who are working to blend western and non-western ways of knowing, have inadequately explored indigenous research procedures. In order to understand indigenous research procedures in the Nepali multi-cultural context, using interpretive, critical and postmodern research paradigms, the authors engaged with indigenous elders and traditional healers, and observed cultural events like shamanic performances. This paper reveals how achieving a profound understanding of indigenous knowledge traditions will be an integral part of how researchers approach indigenous communities in future studies

Indigenous Ways of Knowing in Nepal: Exploring Indigenous Research Procedures in Shamanism

By presenting Shamanism as a form and tradition of indigenous knowledge, this paper aims to reduce the uncertainties attached to the concept in common approaches to indigenous research. Most indigenist researchers, who are working to blend western and non-western ways of knowing, have inadequately explored indigenous research procedures. In order to understand indigenous research procedures in the Nepali multi-cultural context, using interpretive, critical and postmodern research paradigms, the authors engaged with indigenous elders and traditional healers, and observed cultural events like shamanic performances. This paper reveals how achieving a profound understanding of indigenous knowledge traditions will be an integral part of how researchers approach indigenous communities in future studies

Occurrence of phthirapteran ectoparasite parasitizing on domestic dogs, Canis familiaris (Linne) in Jaunpur district (U.P.)

Only two species of biting louse, Heterodoxus spiniger (Enderlein) (43.27%) and Trichodectes canis (De Geer) (13.47%) have been recorded from 245 dogs examined in twelve different localities in Jaunpur district during 2009 to 2011. Female dogs were found most prevalent in comparison to the male in both the cases. Different parameters like host sex, hair colour, hygienic condition, health and age group have been taken into the consideration during the survey. Older age groups, unhealthy and unhygienic condition of dogs were found more prone for the lice. In case of relative intensity of lice 38% were found moderately infested with H. spiniger while 23% and 16% were very light and light infested. Only 12% could be recorded heavy infested dog while 8% remained very heavy infested. Similar trends were recorded for T. canis where moderate infestation followed by very light, light, heavy and very heavy infestation respectively. Besides these two lice, some other ectoparasites (ticks, mites and fleas) (5.31%) were also recorded casually but not used the data for prevalence

Ebola virus - Epidemiology, Diagnosis, and Control: Threat to Humans, Lessons Learnt, and Preparedness Plans - an Update on Its 40 Year\u27s Journey

Ebola virus (EBOV) is an extremely contagious pathogen and causes lethal hemorrhagic fever disease in man and animals. The recently occurred Ebola virus disease (EVD) outbreaks in the West African countries have categorized it as an international health concern. For the virus maintenance and transmission, the non-human primates and reservoir hosts like fruit bats have played a vital role. For curbing the disease timely, we need effective therapeutics/prophylactics, however, in the absence of any approved vaccine, timely diagnosis and monitoring of EBOV remains of utmost importance. The technologically advanced vaccines like a viral-vectored vaccine, DNA vaccine and virus-like particles are underway for testing against EBOV. In the absence of any effective control measure, the adaptation of high standards of biosecurity measures, strict sanitary and hygienic practices, strengthening of surveillance and monitoring systems, imposing appropriate quarantine checks and vigilance on trade, transport, and movement of visitors from EVD endemic countries remains the answer of choice for tackling the EBOV spread. Herein, we converse with the current scenario of EBOV giving due emphasis on animal and veterinary perspectives along with advances in diagnosis and control strategies to be adopted, lessons learned from the recent outbreaks and the global preparedness plans. To retrieve the evolutionary information, we have analyzed a total of 56 genome sequences of various EBOV species submitted between 1976 and 2016 in public databases

Histidylated lipid-modified sendai viral envelopes mediate enhanced membrane fusion and potentiate targeted gene delivery

Recent studies have demonstrated that covalent grafting of a single histidine residue into a twin-chain aliphatic hydrocarbon compound enhances its endosome-disrupting properties and thereby generates an excellent DNA transfection system. Significant increase in gene delivery efficiencies has thus been obtained by using endosome-disrupting multiple histidine functionalities in the molecular architecture of various cationic polymers. To take advantage of this unique feature, we have incorporated L-histidine (N,N-di-n-hexadecylamine) ethylamide (L(H)) in the membrane of hepatocyte-specific Sendai virosomes containing only the fusion protein (F-virosomes (Process for Producing a Targeted Gene (Sarkar, D. P., Ramani, K., Bora, R. S., Kumar, M., and Tyagi, S. K. (November 4, 1997) U. S. Patent 5,683,866))). Such L(H)-modified virosomal envelopes were four times more (p <0.001) active in terms of fusion with its target cell membrane. On the other hand, the presence of L(H) in reconstituted influenza and vesicular stomatitis virus envelopes failed to enhance spike glycoprotein-induced membrane fusion with host cell membrane. Circular dichroism and limited proteolysis experiments with F-virosomes indicated that the presence of L(H) leads to conformational changes in the F protein. The molecular mechanism associated with the increased membrane fusion induced by L(H) has been addressed in the light of fusion-competent conformational change in F protein. Such enhancement of fusion resulted in a highly efficient gene delivery system specific for liver cells in culture and in whole animals

ANALGESIC ACTIVITY OF BARK AND LEAVES OF FICUS RELIGIOSA L. FROM NEPAL

Objective: Because of adverse side effects, caused by NSAIDs, tolerance, and dependence induced by opiates, the use of these analgesic agents has not been successful in all cases. Therefore, alternative analgesic drugs from plant sources are the new target now days. The objective of this study was to evaluate the analgesic activity of ethanolic extracts of stem barks and leaves of Ficus religiosa. Methods: The analgesic activity of ethanolic extract of stem barks and leaves was evaluated in the Swiss albino mice model using acetic acid-induced writing response and Eddy’s hot plate method. Analgesic activity was demonstrated with the percentage inhibition of acetic acid induced writings and the percentage increased in latency time of paw licking. The potency of test extracts was compared with standard drug, Diclofenac. Results: Ethanolic extract of leaves and bark of F. religiosa showed potential analgesic activity from both methods. From Eddy’s hot plate model, it was observed that the percentage of increased latency time at 90 min by ethanolic extract of leaves and stem bark was found to be 70.81 % (8.54 min) and 70.78 % (8.53 min) respectively at a dose of 400 mg/kg. Both of these results are statistically significant (p<0.05) as compared to the test group. Furthermore, both of these extracts showed the dose-dependent and time-dependent increased in latency time and these results are compared to that of standard drug Diclofenac. Similarly, ethanolic extract of leaves and stem at 400 mg/kg significantly inhibited the number of writhings induced by acetic acid. The percentage inhibition of writhings by ethanolic extract of leaves at a dose of 400 mg/kg was 68.47 % which was similar to that of standard drug Diclofenac (68.47 %). However, ethanolic extract of bark showed relatively lower percentage inhibition (60.79 %) as compared to leaf extract and standard, but the result was significant as compared to that of the test group (p<0.05). Conclusion: Ethanolic extracts of F. religiosa stem bark and leaf possess both central and peripheral analgesic properties and these effects may be beneficial for the management of pain

Hydrogeochemistry of Two Major Mid-hill Lentic Water Bodies for Irrigation of the Central Himalaya, Nepal

The concentration and composition of different salts in natural water bodies determine the water quality for various purposes. This study assesses the water quality of two mid-mountain lentic water bodies, Lake Phewa and Kulekhani Reservoir. For this purpose, selected physico-chemical parameters along with major ions such as HCO3-, SO42-, PO43-, NO3-, Cl-, Ca2+, Mg2+, Na+, K+, and NH4+ were analyzed. Major ions were analyzed using ion chromatography, anions by DX-600 and cations by Dionex ISC-2500 ion chromatographs. The sources of major ions were determined by using the Gibbs diagram, Piper plot, and Scatter plots. Dissolved oxygen, ammonia and phosphate showed seasonal variations in both lakes. The concentrations of cations are in the order of Ca2+ > Na+ > Mg2+ > K+ in both water bodies. However the trend of anions had small variations for Cl- and SO42- in Lake Phewa (HCO3- > Cl- > SO42- > NO3-) and Kulekhani Reservoir (HCO3- > SO42- > Cl- > NO3-). The Piper plot and equiline plots indicated that the water chemistry is dominantly controlled by the dissolution of carbonate minerals and to a limited extent by weathering of silicate minerals. This is further supported by the Gibbs plot showing bedrock geology as the main source of major ions. The overall study indicates that the hydrogeochemistry of these water bodies is controlled by local geology and is suitable for irrigation purposes

A systematic review and meta-analysis of the potential of millets for managing and reducing the risk of developing diabetes mellitus

Millets (including sorghum) are known to be highly nutritious besides having a low carbon footprint and the ability to survive in high temperatures with minimal water. Millets are widely recognised as having a low Glycaemic Index (GI) helping to manage diabetes. This systematic review and meta-analyzes across the different types of millets and different forms of processing/cooking collated all evidences. Of the 65 studies that were collected globally, 39 studies with 111 observations were used to analyze GI outcomes and 56 studies were used to analyze fasting, post-prandial glucose level, insulin index and HbA1c outcomes in a meta-analysis. It is evident from the descriptive statistics that the mean GI of millets is 52.7 ± 10.3, which is about 36% lower than in typical staples of milled rice (71.7 ± 14.4) and refined wheat (74.2 ± 14.9). The descriptive, meta and regression analyses revealed that Job's tears, fonio, foxtail, barnyard, and teff were the millets with low mean GI (69). A meta-analysis also showed that all millets had significantly (p < 0.01) lower GI than white rice, refined wheat, standard glucose or white wheat bread except little millet which had inconsistent data. Long term millet consumption lowered fasting and post-prandial blood glucose levels significantly (p < 0.01) by 12 and 15%, respectively, in diabetic subjects. There was a significant reduction in HbA1c level (from 6.65 ± 0.4 to 5.67 ± 0.4%) among pre-diabetic individuals (p < 0.01) who consumed millets for a long period. Minimally processed millets were 30% more effective in lowering GI of a meal compared to milled rice and refined wheat. In conclusion, millets can be beneficial in managing and reducing the risk of developing diabetes and could therefore be used to design appropriate meals for diabetic and pre-diabetic subjects as well as for non-diabetic people for a preventive approach

Millets can have a major impact on improving iron status, hemoglobin level, and in reducing iron deficiency anemia– a systematic review and meta-analysis

The prevalence of iron deficiency anemia is highest among low and middle-income countries. Millets, including sorghum, are a traditional staple in many of these countries and are known to be rich in iron. However, a wide variation in the iron composition of millets has been reported, which needs to be understood in consonance with its bioavailability and roles in reducing anemia. This systematic review and meta-analysis were carried out to analyze the scientific evidence on the bioavailability of iron in different types of millets, processing, and the impact of millet-based food on iron status and anemia. The results indicated that iron levels in the millets used to study iron bioavailability (both in vivo and in vitro) and efficacy varied with the type and variety from 2 mg/100 g to 8 mg/100 g. However, not all the efficacy studies indicated the iron levels in the millets. There were 30 research studies, including 22 human interventions and 8 in vitro studies, included in the meta-analysis which all discussed various outcomes such as hemoglobin level, serum ferritin level, and absorbed iron. The studies included finger millet, pearl millet, teff and sorghum, or a mixture of millets. The results of 19 studies conducted on anaemic individuals showed that there was a significant (p < 0.01) increase in hemoglobin levels by 13.2% following regular consumption (21 days to 4.5 years) of millets either as a meal or drink compared with regular diets where there was only 2.7% increase. Seven studies on adolescents showed increases in hemoglobin levels from 10.8 ± 1.4 (moderate anemia) to 12.2 ± 1.5 g/dl (normal). Two studies conducted on humans demonstrated that consumption of a pearl millet-based meal significantly increased the bioavailable iron (p < 0.01), with the percentage of bioavailability being 7.5 ± 1.6, and provided bioavailable iron of 1 ± 0.4 mg. Four studies conducted on humans showed significant increases in ferritin level (p < 0.05) up to 54.7%. Eight in-vitro studies showed that traditional processing methods such as fermentation and germination can improve bioavailable iron significantly (p < 0.01) by 3.4 and 2.2 times and contributed to 143 and 95% of the physiological requirement of women, respectively. Overall, this study showed that millets can reduce iron deficiency anemia