Prediction of Human Intestinal Absorption

The proposed human intestinal absorption prediction model is applied to over 900 pharmaceuticals and has about 82.5% true prediction power. This study will provide a screening tool that can differentiate well absorbed and poorly absorbed drugs in the early stage of drug discovery and development. This model is based on fundamental physicochemical properties and can be applied to virtual compounds. The maximum well-absorbed dose (i.e., the maximum dose that will be more than 50 percent absorbed) calculated using this model can be utilized as a guideline for drug design, synthesis, and pre-clinical studies.Release after 22-Dec-201

Strong unitary and overlap uncertainty relations: theory and experiment

We derive and experimentally investigate a strong uncertainty relation valid for any $n$ unitary operators, which implies the standard uncertainty relation as a special case, and which can be written in terms of geometric phases. It is saturated by every pure state of any $n$-dimensional quantum system, generates a tight overlap uncertainty relation for the transition probabilities of any $n+1$ pure states, and gives an upper bound for the out-of-time-order correlation function. We test these uncertainty relations experimentally for photonic polarisation qubits, including the minimum uncertainty states of the overlap uncertainty relation, via interferometric measurements of generalised geometric phases.Comment: 5 pages of main text, 5 pages of Supplemental Material. Clarifications added in this updated versio

Overview Of In-Situ Gelling System For Diabetic Wound

The "in situ gel" system has become one of the best innovative drug delivery methods; thanks to its unique property of "Sol to Gel" transition, it aids in the prolonged and regulated release of the pharmaceuticals. An in situ gelling system is a formulation that, before entering the body, is in solution form but transforms into a gel under different physiological circumstances. Different polymers can potentially be utilized for different drug administration routes and go through in situ gel formation. In situ gelling systems have a variety of uses and benefits in modern society. The introduction to in situ gel, its mechanism, the numerous polymers utilized, and its applications are the primary topics of this paper. Through a challenging biological process known as wound healing, damaged tissues are rebuilt and skin integrity is recovered. Insulin, a crucial component in wound healing, has been proven in numerous studies to speed up the healing of a variety of wounds in both people and animals. Despite the fact that several research have looked at how systemic insulin can treat burn wounds, relatively few have looked at how well topical insulin works. Therefore, the objective of this study was to review the information on the effects of topical insulin on both diabetic and non-diabetic wound healing. Topical insulin improves quicker wound healing through a variety of mechanisms without causing any harmful side effects, according to published animal and clinical experiments. Additionally, a number of wound dressings that deliver bioactive insulin gradually and regularly hasten the healing process. Therefore, topical insulin has been valued in the field of wound healing, and additional research is required to better understand the role of insulin in the healing of different types of wound

A comparative study of vaginal misoprostol versus oral misoprostol for induction of labour

Background: Induction of labour defined as artificial initiation of uterine contractions before the onset of spontaneous labour, after the period of viability, by any methods. The successful outcome depends on the Bishop Score, maternal age and parity. Authors compared the most preferred two routes; vaginal and oral for induction and outcome, adverse events and side effects were noted.Methods: This was a prospective comparative study carried out at SVPIMSR, Ahmedabad, from January 2019 to June 2019, Gujarat, 100 patients who required induction were randomly divided in two groups- Group A received 25µg oral misoprostol, Group B - received 25µg vaginal misoprostol repeated 4 hourly up to maximum five doses in both groups. The induction to delivery interval, mode of delivery, maternal and neonatal outcome and complications were observed.Results: The mean induction to delivery interval was less in vaginal group than oral (18.7 hours in vaginal versus 22.4 hours in oral). Vaginal delivery and caesarean section rates were comparable in both groups. 60% patients in Group A required more than two doses as compared to 36% in Group B. No major complications or adverse events were observed.Conclusions: Both oral misoprostol in a dose of 25μg and vaginal misoprostol 25μg every four hours, to a maximum of five doses, have safety and efficacy for induction. With The vaginal route, delivery occurs in less time and few doses required as compared to oral

Single-shot quantum memory advantage in the simulation of stochastic processes

Stochastic processes underlie a vast range of natural and social phenomena. Some processes such as atomic decay feature intrinsic randomness, whereas other complex processes, e.g. traffic congestion, are effectively probabilistic because we cannot track all relevant variables. To simulate a stochastic system's future behaviour, information about its past must be stored and thus memory is a key resource. Quantum information processing promises a memory advantage for stochastic simulation that has been validated in recent proof-of-concept experiments. Yet, in all past works, the memory saving would only become accessible in the limit of a large number of parallel simulations, because the memory registers of individual quantum simulators had the same dimensionality as their classical counterparts. Here, we report the first experimental demonstration that a quantum stochastic simulator can encode the relevant information in fewer dimensions than any classical simulator, thereby achieving a quantum memory advantage even for an individual simulator. Our photonic experiment thus establishes the potential of a new, practical resource saving in the simulation of complex systems

Study of Detached (Fresh) Leaf and Dried Leaf with Image Processing

Agriculture is the keystone of human being provisions on this world. Now with rising inhabitants we need the efficiency of the agriculture to be augmented a lot to meet the demands. In ancient days they used natural methods to boost the yield, such as using the animal dung as manure in the fields. That resulted increase in the productivity sufficient to meet the requirements of the population. Although later people started thinking of earning more profits by getting more result. So, there came a revolution called “Green Revolution”. So, in this paper we have carried out some methods to measure the plant growth by the means of having area of a leaf. The study gives aspect of comparing the detached leaf with the dried leaf and it will be helpful to researcher to evaluate the dryness and also it will be helpful for the analysis at the time of biodegradation of the leaves and for the generation of organic manures. In this paper we implemented image processing using IJ (Image J 1.48V – Java 1.6.0_20(32- bit)) to measure various image processing related functions. And images of plants we took from D. K. Parmar’s field. DOI: 10.17762/ijritcc2321-8169.15011

Giant Stark effect in the emission of single semiconductor quantum dots

We study the quantum-confined Stark effect in single InAs/GaAs quantum dots embedded within a AlGaAs/GaAs/AlGaAs quantum well. By significantly increasing the barrier height we can observe emission from a dot at electric fields of -500 kV/cm, leading to Stark shifts of up to 25 meV. Our results suggest this technique may enable future applications that require self-assembled dots with transitions at the same energy

A study of gestational diabetes mellitus and fetal outcome in a tertiary care center

Background: Modern desk-bound lifestyle and unhealthy dietary changes have brought a rise in the prevalence of obesity and gestational diabetes mellitus (GDM). It is associated with severe hazards to the mother and the baby. It is mandatory that early diagnosis ensues and timely and congruous management is undertaken.Methods: In this observational study, 1250 women were included. A standardized questionnaire was formed and their details were noted. Tests for glucose levels, complete blood picture, urine examination were performed. An oral glucose tolerance test was performed on all the patients. Neonatal outcomes in terms of birth weight and the presence of complications were noted.Results: A total 201 (16.1%) of all women were having gestational diabetes mellitus (GDM). Most mothers were in the 25-30 age group. The majority of the women had a BMI between 26-30. 21.9% of babies were having weight >3.5 kgs. 11.4% of babies were <2.5 kgs. Out of 201 neonates, 90 babies were having complications. Major complications in neonates were macrosomia and respiratory distress. Therefore, early diagnosis, glycemic control, and timely and congruous management are advantageous to both mother and baby.Conclusions: GDM complicating the pregnancy results in a higher prevalence of complications in the mother and the neonate. Therefore, appropriate control of the sugar level in mothers is necessary and it decreases the morbidity and mortality rates in the babies as well as the mothers.

Bianchi Type I Massive String Magnetized Barotropic Perfect Fluid Cosmological Model in General Relativity

Bianchi type I massive string cosmological model with magnetic field of barotropic perfect fluid distribution through the techniques used by Latelier and Stachel, is investigated. To get the deterministic model of the universe, it is assumed that the universe is filled with barotropic perfect fluid distribution. The magnetic field is due to electric current produced along x-axis with infinite electrical conductivity. The behaviour of the model in presence and absence of magnetic field together with other physical aspects is further discussed.Comment: 10 pages, no figure. Chin. Phys. Lett., Vol. 24, No. 8 (2007), to appea