What is the impact of sex hormones on the pathogenesis of rheumatoid arthritis?

Rheumatoid arthritis (RA) is the most common inflammatory rheumatic disease and has a female predominance of around 3:1. The relationship between sex hormones and RA has been of great interest to researchers ever since Philip Hench's observations in the 1930's regarding spontaneous disease amelioration in pregnancy. Extensive basic scientific work has demonstrated the immunomodulatory actions of sex hormones but this therapeutic potential has not to date resulted in successful clinical trials in RA. Epidemiological data regarding both endogenous and exogenous hormonal factors are inconsistent, but declining estrogen and/or progesterone levels in the menopause and post-partum appear to increase the risk and severity of RA. This review assimilates basic scientific, epidemiological and clinical trial data to provide an overview of the current understanding of the relationship between sex hormones and RA, focusing on estrogen, progesterone and androgens

Pollen sedimentation in relation to the Quaternary vegetation history of the Snowy Mountains of New South Wales

Pollen influx into Blue Lake in the alpine area of the Snowy Mountains of southeastern Australia was measured by pollen traps, snow and stream water samples and lake sediment traps. Pollen deposition in a nearby forested area was also investigated. Pollen deposition rates were calculated for a pair of cores from the lake, yielding a record over the last 13000 years, supplementary material from the nearby Twynam Cirque extending the sequence to 20000 years B.P. Possible causes of distortions in the pollen diagrams arising from differential pollen deposition and sediment redeposition are regarded as not significant. Vegetation was absent from the area before 17000 B.P., when snowpatch and feldmark communities appeared. Further amelioration occurred between 13000 and 17000 years B.P., after which conditions appeared to remain the same until 8700 years B.P., when a great increase in total pollen deposition rate was associated with rise of the treeline to its present position, and further development of the alpine vegetation. Forest of moister aspect than the present day prevailed from 7700 to 6500 years B.P., after which relative wetness declined to a minimum at about 3800 years B.P. Slight increase in available moisture has occurred since 1500 years B.P

Clinical practice as research for a rare condition: Systematic research review of qualitative research exploring patients' experiences of penile cancer

Background: Penile cancer is a rare but destructive malignancy. The aim of this study was to identify published qualitative research exploring patients' experiences of being diagnosed and treated for penile cancer. As only one study met our inclusion criteria and yet there were five borderline studies, a secondary aim that emerged was to discuss those studies to see what, if anything, we could learn. Methods: We searched ASSIA, CINAHL, EMBASE, PUBMED/MEDLINE, PsycINFO & Web of Science and found 313 papers published since 1990. Two reviewers independently selected 17 papers for potential inclusion using titles and abstracts, which were obtained and independently assessed. A synthesis was not possible as only one study met our inclusion criteria. Five borderline studies, covering 4 countries, invited closer inspection because they are often reported in guidelines on penile cancer. Results: The 5 borderline studies reported using a mixed methods design combining a psychometric measure with interviews. Unfortunately, none of these studies reported the method or process used for analysing qualitative data or for integrating the interview and psychometric findings, making it difficult to understand the interview element of their research. Conclusions: If we are to understand and improve the long-term consequences of treatment for penile cancer, qualitative studies of patients’ experiences need to be conducted with high quality analysis and reporting. While pen-and-paper questionnaires may take up little of the time of clinicians conducting research about rare conditions, time could be better used by using methodologies that explore patients experiences

Early evolution of the angiosperm clade Asteraceae in the Cretaceous of Antarctica

The Asteraceae (sunflowers and daisies) are the most diverse family of flowering plants. Despite their prominent role in extant terrestrial ecosystems, the early evolutionary history of this family remains poorly understood. Here we report the discovery of a number of fossil pollen grains preserved in dinosaur-bearing deposits from the Late Cretaceous of Antarctica that drastically pushes back the timing of assumed origin of the family. Reliably dated to ∼76–66 Mya, these specimens are about 20 million years older than previously known records for the Asteraceae. Using a phylogenetic approach, we interpreted these fossil specimens as members of an extinct early diverging clade of the family, associated with subfamily Barnadesioideae. Based on a molecular phylogenetic tree calibrated using fossils, including the ones reported here, we estimated that the most recent common ancestor of the family lived at least 80 Mya in Gondwana, well before the thermal and biogeographical isolation of Antarctica. Most of the early diverging lineages of the family originated in a narrow time interval after the K/P boundary, 60–50 Mya, coinciding with a pronounced climatic warming during the Late Paleocene and Early Eocene, and the scene of a dramatic rise in flowering plant diversity. Our age estimates reduce earlier discrepancies between the age of the fossil record and previous molecular estimates for the origin of the family, bearing important implications in the evolution of flowering plants in general.Los datos utilizados en este trabajo pueden accederse haciendo clic en "Documentos relacionados".Facultad de Ciencias Naturales y Muse

Lower Jurassic (Hettangian–Pliensbachian) microfossil biostratigraphy of the Ballinlea-1 well, Rathlin Basin, Northern Ireland, United Kingdom

The thickest section of Early Jurassic strata known from onshore Ireland (total Jurassic thickness 566 m) is reported from the Ballinlea-1 well (Rathlin Basin) situated on the north coast of Northern Ireland. A biostratigraphical and palaeoenvironmental assessment is presented for this section largely based on calcareous benthic microfossils (foraminifera and ostracods). The Early Jurassic Waterloo Mudstone Formation (Lias Group) of Northern Ireland has previously received little micropalaeontological attention, therefore this work provides an opportunity to enhance palaeogeographic and palaeoenvironmental understanding for the Early Jurassic of the province, and this paper illustrates the key microfossil taxa of this age from Ireland for the first time. The records, based on ditch-cuttings samples, demonstrate a stratigraphical range from Hettangian to Early Pliensbachian, consistent with other wells and boreholes in this basin. The assemblage compositions are comparable to those elsewhere in the European boreal Atlantic realm. Hettangian to earliest Sinemurian microfossil assemblages are generally of low diversity and are numerically dominated by metacopid ostracods with occasional influxes of foraminifera. Gradually, foraminiferal abundance (often dominated by species of the Lagenida) come to exceed those of the ostracods in the Early Sinemurian reaching their greatest diversity in the Late Sinemurian. The sediments are considered to represent an inner to mid-shelf environment throughout while the record thickness for this region indicates ongoing syn-sedimentary fault movement along the basin margins within this period

DAS28(3)CRP is a reliable measure of disease activity in pregnant women with rheumatoid arthritis

OBJECTIVES: The disease activity of rheumatoid arthritis (RA) in pregnancy is most commonly assessed with the modified Disease Activity Score (DAS)-28, the DAS28(3)CRP. However, the performance of the DAS28(3)CRP in pregnancy has not been compared to musculoskeletal ultrasound (MSK-US) as a gold standard. We performed a prospective pilot study to test the hypothesis that pregnancy-related factors limit the reliability of the DAS28(3)CRP. METHODS: Pregnant women with RA were recruited from an Obstetric Rheumatology clinic and assessed during pregnancy (second (T2) and third (T3) trimesters) and postpartum with DAS28(3)CRP and MSK-US scores, with quantification of power Doppler (PD) signal in small joints (hands and feet). Age-matched non-pregnant women with RA underwent equivalent assessments. PD scores were calculated as mean scores of all joints scanned. RESULTS: We recruited 27 pregnant and 20 non-pregnant women with RA. DAS28(3)CRP was sensitive and specific for active RA in pregnancy and postpartum as defined by positive PD signal, but not in non-pregnancy. There were significant correlations between DAS28(3)CRP and PD scores throughout pregnancy (T2, r=0.82 (95% CI [0.42, 0.95], p<0.01); T3, r=0.68 (95% CI [0.38, 0.86], p<0.01)) and postpartum, r=0.84 (95% CI [0.60, 0.94], p<0.01), while this correlation in non-pregnancy was weaker (r=0.47 (95% CI [0, 0.77], p<0.05). CONCLUSIONS: This pilot study found that DAS28(3)CRP is a reliable measure of disease activity in pregnant women with RA. Based on these data, pregnancy does not appear to confound clinical evaluation of the tender and/or swollen joint counts

Uppermost Triassic to Lower Jurassic sediments of the island of Ireland and its surrounding basins

The uppermost Triassic to Lower Jurassic interval has not been extensively studied across the island of Ireland. This paper seeks to redress that situation and presents a synthesis of records of the uppermost Triassic and Lower Jurassic from both onshore and offshore basins as well as describing the sedimentological characteristics of the main lithostratigraphical units encountered. Existing data have been supplemented with a re-examination and logging of some outcrops and the integration of data from recent hydrocarbon exploration wells and boreholes. The Late Triassic Penarth Group and Early Jurassic Lias Group can be recognised across the Republic of Ireland and Northern Ireland. In some onshore basins, almost 600 m of strata are recorded, however in offshore basins thicknesses in excess of two kilometres for the Lower Jurassic have now been recognised, although little detailed information is currently available. The transition from the Triassic to the Jurassic was a period of marked global sea-level rise and climatic change (warming) and this is reflected in the lithostratigraphical record of these sediments in the basins of Northern Ireland and offshore basins of the Republic of Ireland. In general, the sediments of this interval are thicker than those in Great Britain and have potential for detailed study of climatic and sea-level fluctuation