3 research outputs found

    Behavioral RCT using internet- based social interactions: Why some gain and some do not

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    BackgroundIncreasing social interaction could be a promising intervention for improving the cognitive well- being of socially isolated older adults. However, we expect that the efficacy of a social intervention can differ across subjects due to personality traits, preference for specific activities, and different pathological stages, even within the same clinical diagnosis. For most behavioral intervention studies, the priority of randomized controlled trials is not necessarily to gain a statistically significant intervention effect, but to find which subjects benefit from the specific intervention. Factoring this potential heterogeneity into the efficacy analysis of randomized controlled trials (RCT) will be discussed.MethodsBuilding upon our previously completed NIH- funded project (ClinicalTrials.gov #: NCT01571427), we developed a multi- site RCT to examine whether conversation- based cognitive stimulation has a positive effect on domain- specific cognitive functions and higher- order objectively measured IADL (Instrumental Activities of Daily Living). We target socially isolated older adults with either normal cognition or mild cognitive impairment (Internet- Based Conversational Engagement Clinical Trial (I- CONECT), ClinicalTrials.gov # NCT02871921). The experimental group engages in semi- structured video- chat conversation with trained conversational staff 4 times per week for 6 months (high dose) and twice per week for additional 6 months (maintenance dose). In addition to the main outcomes of neuropsychological test scores, we aim to determine factors which lead to heterogeneities in efficacy including: baseline brain atrophy and connectivity using MRI/fMRI, personality, Apoe genotype, mood and nature of social isolation (emotional vs. structural).ResultsWhile recruiting socially isolated subjects is challenging, as of January, 2020, our study has reached out 26,000 subjects, screened 195 subjects, and 131 subjects were ultimately randomized with 40% of those being eligible for MRI assessment. Baseline recruitment will continue until March of 2021. Carefully considered outcomes, covariates and mediating factors are being collected in this RCT. This presentation will examine some of the key heterogeneities observed in our ongoing baseline sample, and discuss potential implications these differences may have on our future efficacy analysis.ConclusionsOur project serves as a reference for developing individualized, targeted community intervention strategies with high adherence with maintainable life style modifications.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/163794/1/alz046367.pd

    Perspective on the “African American participation in Alzheimer disease research: Effective strategies” workshop, 2018

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    The Washington University School of Medicine Knight Alzheimer Disease Research Center’s “African American Participation in Alzheimer Disease Research: Effective Strategies” Workshop convened to address a major limitation of the ongoing scientific progress regarding Alzheimer disease and related dementias (ADRD): participants in most ADRD research programs overwhelmingly have been limited to non-Hispanic white persons, thus precluding knowledge as to how ADRD may be represented in non-white individuals. Factors that may contribute to successful recruitment and retention of African Americans into ADRD research were discussed and organized into actionable next steps as described within this report
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