Novel symmetric bis-benzimidazoles: Synthesis, DNA/RNA binding and antitrypanosomal activity.

The novel benzimidazol-2-yl-fur-5-yl-(1,2,3)-triazolyl dimeric series with aliphatic and aromatic central linkers was successfully prepared with the aim of assessing binding affinity to DNA/RNA and antitrypanosomal activity. UV-Visible spectroscopy, thermal denaturation showed interaction of heterocyclic bis-amidines with ctDNA. Circular dichroism studies indicated uniform orientation of heterocyclic bis-amidines along the chiral double helix axis, revealing minor groove binding as the dominant binding mode. The amidino fragment and 1,4-bis(oxymethylene)phenyl spacer were the main determinants of activity against Trypanosoma brucei. The bis-benzimidazole imidazoline 15c, which had antitrypanosomal potency in the submicromolar range and DNA interacting properties, emerged as a candidate for further structural optimization to obtain more effective agents to combat trypanosome infections

A numerical analysis as a good tool for a prediction of final sulphur steel ladle content

This work presents the industrial results of sulfur level prediction at the end of vacuum degassing (VD) of low carbon Al-Si killed steels. The effect of plant conditions, such as slag chemistry, temperature, oxygen levels of the molten steel, and slag weight on desulphurization was investigated based on the measured results and thermodynamic calculations. The variables which influence steel desulfurization such as the sulfur capacity, the initial sulfur content, and the amount of ladle slag at the end of the VD process are also defined. The desulfurization procedure was numerically analyzed using the results of 31 heats under real plant conditions in which the measured final sulfur content had been reduced to less than of 10 ppm. A method for prediction of the slag amount based on the material balance of sulfur and aluminum is also presented. The values of the sulfur capacity were determined according to the well-known KTH and optical basicity based models. The obtained results of the regression equation show a predictive final sulfur level ability of R=0.911. This was proved as satisfactory

A numerical analysis as a good tool for a prediction of final sulphur steel ladle content

This work presents the industrial results of sulfur level prediction at the end of vacuum degassing (VD) of low carbon Al-Si killed steels. The effect of plant conditions, such as slag chemistry, temperature, oxygen levels of the molten steel, and slag weight on desulphurization was investigated based on the measured results and thermodynamic calculations. The variables which influence steel desulfurization such as the sulfur capacity, the initial sulfur content, and the amount of ladle slag at the end of the VD process are also defined. The desulfurization procedure was numerically analyzed using the results of 31 heats under real plant conditions in which the measured final sulfur content had been reduced to less than of 10 ppm. A method for prediction of the slag amount based on the material balance of sulfur and aluminum is also presented. The values of the sulfur capacity were determined according to the well-known KTH and optical basicity based models. The obtained results of the regression equation show a predictive final sulfur level ability of R=0.911. This was proved as satisfactory

Prednosti uspostavljanja i kontrola režima livenja na primeru odlivka klipa

S. Manasijević, R. Radiša, Z. Pavlović-Aćimović,K. Raić, Prednosti uspostavljanja i kontrola režima livenja na primeru odlivka klipa, LIVARSTV

Optimization technological parameters of piston casting using information technology

Optimization technological parameters of piston casting using information technology, 12th International Foundrymen Conference, Sustainable Development in Foundry Materials and Technologie

Persistent organochlorine compounds in human milk collected in Croatia over two decades

The distribution and time trend of organochlorine pesticide (OCP), polychlorinated biphenyl (PCB), and polychlorinated dibenzo-p-dioxin/polychlorinated dibenzofuran (PCDD/PCDF) concentrations in human milk samples from Croatia collected in 1981-2003 are presented. Between 1981/1982 and 1987/1989, the concentrations of HCB, beta-HCH, DDE, and total PCBs decreased about 50%, while for the last decade, the concentrations have been decreasing very slowly. In 2002/2003 the range of PCB congeners and OCPs was from below the limit of determination to 332 ng g(-1) milk fat. PCDD/PCDF concentrations in human milk samples collected in 1981-2000 ranged between 5.2 and 26.7 pg I-TEQ g(-1) milk fat and showed a decreasing trend