3 research outputs found
Route to Benzimidazol-2-ones via Decarbonylative Ring Contraction of Quinoxalinediones: Application to the Synthesis of Flibanserin, A Drug for Treating Hypoactive Sexual Desire Disorder in Women and Marine Natural Product Hunanamycin Analogue
A simple and practical method to
access a variety of benzimidazol-2-ones
is reported here. A series of <i>N</i>-alkyl-substituted
benzimidazol-2-ones were synthesized by decarbonylative ring contraction
starting from corresponding quinoxalinediones for the first time.
The utility of the method has been demonstrated by synthesizing recently
approved controversial drug flibanserin (Addyi) and a urea analogue
of marine antibiotic natural product hunanamycin-A