The effects of noise on biochemical parameters using rat's hearts

The present study was undertaken to evaluate the effect of acute and chronic high intensity noise on plasma blood glucose concentration and lipid profile of rats. The rats were divided into four groups and they include exposure to noise of intensity 80-100 dBA on duration of 12 hours exposure (acute effect), 8 hours daily for 20 days (chronic effect), 20 days into 3 days exposure and 2 days without 8 hours per day (intermittent effect) and the control group. Noise of 80-100 dBA was found to cause significant increase in plasma glucose for the acute and chronic continuous groups as compared to no noise exposure. The cholesterol, triglycerides (TG) and high density lipoprotein (HDL) had no significant difference compared to control. HDL level revealed significant elevation in case of chronic continuous and intermittent noise exposure (p < 0.05) when compared to control group. In conclusion the present study determined that high intensity noise may have an adverse effect on biochemical values and thus noise exposure should be well monitored

The effects of noise on cardiovascular parameters using isolated rat`s hearts

Prolonged exposure to noise can have adverse effects on health. Noise has extra auditory effects by activating the sympathetic nervous and hormonal systems. The present study was undertaken to evaluate the effect of acute and chronic high intensity noise on the isolated hearts of rats using the Langendorff apparatus by determining the effect of noise on the coronary perfusion pressure(CPP), heart rate (HR) and left ventricular diastolic pressure (LVDP). The rats were divided into four groups and exposed to noise intensity of 80-100 dBA on duration of 12 hours exposure(acute effect), 8 hours daily for 20 days (chronic effect), 20 days into 3 days exposure and 2 days without 8 hours per day (intermittent effect) and the control group. Noise of 80-100 dBA was found to cause significant increase in CPP, LVDP and HR (p< 0.05) for acute and both chronic groups versus control. On other hand there were no significant differences of the CPP,LVDP and HR between the chronic intermittent group with the chronic continuous noise exposure group. It can be concluded that high intensity noise may have an adverse effect on cardiovascular functions and thus noise exposure should be well monitored

In vitro evaluation of antimicrobial activity of crude extracts of Garcinia griffithii plant against some pathogenic microorganisms

Nowadays, researchers are focusing their attention towards folk medicine for developing better drugs against microbial infections. The present study aimed to evaluate the inhibitory activity of crude extracts from Garcinia griffithii plant. The plant materials were extracted using solvents with different polarities. The solvent extracts were screened and then tested for antimicrobial activities. It was found that the polar extracts, i.e. methanol and ethyl acetate, showed higher antimicrobial activities than the non polar (Hexane) extract. In previous study, screening test for phytochemicals constituents of the plant showed that, the leaf extract of the plant possessed the active principles e.g. terpenoids, tannins, saponins and glycosides. The antimicrobial activity of the extracts was assayed against four bacteria and two fungal strains using the agar disc diffusion method by indicating the presence of the clear inhibition zones around each disc. Methanolic extract showed the highest inhibition zone of (18±3.4mm) against S. aureus compared with ethyl acetate (10±0.05 mm) and hexane extracts (8±0.05 mm)

Preliminary phytochemical screening test of Garcinia griffithii plant

Nowadays, researchers are focusing their attention towards folk medicine for developing better drugs against microbial infections. The present study aimed to evaluate the phytochemical constituents from Garcinia griffithii plant. The plant materials were extracted using solvents with different polarities (methanol, ethyl acetate and hexane). The solvent extracts were screened and the results of screening test for phytochemicals showed that, the presence of various metabolites in different solvents. only the phenolic groups were presented in hexane and ethyl acetate extracts, whereas, The methanol extract contains terpenoids, alkaloids, flavonoids, saponins and glycosides, and those chemical compounds possess antibacterial activities against pathogenic microorganisms

The correlation between serum leptin and blood pressure after exposure to noise at work

Several epidemiologic studies have reported that exposure to noise is associated with cardiovascular disease. The increased body weight is often associated with metabolic as well as increased blood pressure. The aim of this study is to investigate the correlation between the elevation of blood pressure and serum leptin hormones due to the effects of noise in the work place. A total of 80 volunteer males where included in this study with an age range between of 20 and 45 years, they were divided in two groups equally, the 1st group were exposed to noise in the workplace while the 2nd group were not. The individual noise exposure was determined by using a sound level meter. The range of noise was 80-100 dBA. Body Mass Index was also taken for each individual by a standard measure, blood pressure was measured by OMRON sphygmomanometer and serum leptin was measured through venous blood sample analysis enzyme linked immunosorbent assay. Spearman rank order correlation was used to examine the correlations between Blood pressure value (Systolic, Diastolic) and Leptin. All the relationships between parameters showed a positive correlation. Systolic and diastolic blood pressure values had a significant correlation to leptin hormone level in comparison to the control. There was a significant relation between leptin and blood pressure. leptin effects on the sympathetic nervous system may provide a partial explanation. Therefore, Leptin might have diverse cardiovascular actions