1,023 research outputs found
Distributed Holistic Clustering on Linked Data
Link discovery is an active field of research to support data integration in
the Web of Data. Due to the huge size and number of available data sources,
efficient and effective link discovery is a very challenging task. Common
pairwise link discovery approaches do not scale to many sources with very large
entity sets. We here propose a distributed holistic approach to link many data
sources based on a clustering of entities that represent the same real-world
object. Our clustering approach provides a compact and fused representation of
entities, and can identify errors in existing links as well as many new links.
We support a distributed execution of the clustering approach to achieve faster
execution times and scalability for large real-world data sets. We provide a
novel gold standard for multi-source clustering, and evaluate our methods with
respect to effectiveness and efficiency for large data sets from the geographic
and music domains
Transformation Optics for Plasmonics
A new strategy to control the flow of surface plasmon polaritons at metallic
surfaces is presented. It is based on the application of the concept of
Transformation Optics to devise the optical parameters of the dielectric medium
placed on top of the metal surface. We describe the general methodology for the
design of Transformation-Optical devices for surface plasmons and analyze, for
proof-of-principle purposes, three representative examples with different
functionalities: a beam shifter, a cylindrical cloak and a ground-plane cloak.Comment: 15 pages, 3 figure
Zeta Determinant for Laplace Operators on Riemann Caps
The goal of this paper is to compute the zeta function determinant for the
massive Laplacian on Riemann caps (or spherical suspensions). These manifolds
are defined as compact and boundaryless dimensional manifolds deformed by a
singular Riemannian structure. The deformed spheres, considered previously in
the literature, belong to this class. After presenting the geometry and
discussing the spectrum of the Laplacian, we illustrate a method to compute its
zeta regularized determinant. The special case of the deformed sphere is
recovered as a limit of our general formulas.Comment: 19 pages, 1 figur
Theorem on the Distribution of Short-Time Particle Displacements with Physical Applications
The distribution of the initial short-time displacements of particles is
considered for a class of classical systems under rather general conditions on
the dynamics and with Gaussian initial velocity distributions, while the
positions could have an arbitrary distribution. This class of systems contains
canonical equilibrium of a Hamiltonian system as a special case. We prove that
for this class of systems the nth order cumulants of the initial short-time
displacements behave as the 2n-th power of time for all n>2, rather than
exhibiting an nth power scaling. This has direct applications to the initial
short-time behavior of the Van Hove self-correlation function, to its
non-equilibrium generalizations the Green's functions for mass transport, and
to the non-Gaussian parameters used in supercooled liquids and glasses.Comment: A less ambiguous mathematical notation for cumulants was adopted and
several passages were reformulated and clarified. 40 pages, 1 figure.
Accepted by J. Stat. Phy
Charge-Dependence of the Nucleon-Nucleon Interaction
Based upon the Bonn meson-exchange-model for the nucleon-nucleon ()
interaction, we calculate the charge-independence breaking (CIB) of the
interaction due to pion-mass splitting. Besides the one-pion-exchange (OPE), we
take into account the -exchange model and contributions from three and
four irreducible pion exchanges. We calculate the CIB differences in the
effective range parameters as well as phase shift differences for
partial waves up to total angular momentum J=4 and laboratory energies below
300 MeV. We find that the CIB effect from OPE dominates in all partial waves.
However, the CIB effects from the model are noticable up to D-waves and
amount to about 40% of the OPE CIB-contribution in some partial waves, at 300
MeV. The effects from 3 and 4 contributions are negligible except in
and .Comment: 12 pages, RevTex, 14 figure
MALT1 Phosphorylation Controls Activation of T Lymphocytes and Survival of ABC-DLBCL Tumor Cells
The CARMA1/CARD11-BCL10-MALT1 (CBM) complex bridges T and B cell antigen receptor (TCR/BCR) ligation to MALT1 protease activation and canonical nuclear factor kappa B (NF-kappa B) signaling. Using unbiased mass spectrometry, we discover multiple serine phosphorylation sites in the MALT1 C terminus after T cell activation. Phospho-specific antibodies reveal that CBM-associated MALT1 is transiently hyper-phosphorylated upon TCR/CD28 co-stimulation. We identify a dual role for CK1 alpha as a kinase that is essential for CBM signalosome assembly as well as MALT1 phosphorylation. Although MALT1 phosphorylation is largely dispensable for protease activity, it fosters canonical NF-kappa B signaling in Jurkat and murine CD4 T cells. Moreover, constitutive MALT1 phosphorylation promotes survival of activated B cell-type diffuse large B cell lymphoma (ABC-DLBCL) cells addicted to chronic BCR signaling. Thus, MALT1 phosphorylation triggers optimal NF-kappa B activation in lymphocytes and survival of lymphoma cells
Charge-Asymmetry of the Nucleon-Nucleon Interaction
Based upon the Bonn meson-exchange model for the nucleon-nucleon ()
interaction, we study systematically the charge-symmetry-breaking (CSB) of the
interaction due to nucleon mass splitting. Particular attention is payed
to CSB generated by the -exchange contribution to the interaction,
diagrams, and other multi-meson-exchanges. We calculate the CSB
differences in the effective range parameters as well as phase shift
differences in , and higher partial waves up to 300 MeV lab. energy. We
find a total CSB difference in the singlet scattering length of 1.6 fm which
explains the empirical value accurately. The corresponding CSB phase-shift
differences are appreciable at low energy in the state. In the other
partial waves, the CSB splitting of the phase shifts is small and increases
with energy, with typical values in the order of 0.1 deg at 300 MeV in and
waves.Comment: 11 pages, RevTex, 14 figure
Magnetic vortex oscillator driven by dc spin-polarized current
Transfer of angular momentum from a spin-polarized current to a ferromagnet
provides an efficient means to control the dynamics of nanomagnets. A peculiar
consequence of this spin-torque, the ability to induce persistent oscillations
of a nanomagnet by applying a dc current, has previously been reported only for
spatially uniform nanomagnets. Here we demonstrate that a quintessentially
nonuniform magnetic structure, a magnetic vortex, isolated within a nanoscale
spin valve structure, can be excited into persistent microwave-frequency
oscillations by a spin-polarized dc current. Comparison to micromagnetic
simulations leads to identification of the oscillations with a precession of
the vortex core. The oscillations, which can be obtained in essentially zero
magnetic field, exhibit linewidths that can be narrower than 300 kHz, making
these highly compact spin-torque vortex oscillator devices potential candidates
for microwave signal-processing applications, and a powerful new tool for
fundamental studies of vortex dynamics in magnetic nanostructures.Comment: 14 pages, 4 figure
Beyond Volume: The Impact of Complex Healthcare Data on the Machine Learning Pipeline
From medical charts to national census, healthcare has traditionally operated
under a paper-based paradigm. However, the past decade has marked a long and
arduous transformation bringing healthcare into the digital age. Ranging from
electronic health records, to digitized imaging and laboratory reports, to
public health datasets, today, healthcare now generates an incredible amount of
digital information. Such a wealth of data presents an exciting opportunity for
integrated machine learning solutions to address problems across multiple
facets of healthcare practice and administration. Unfortunately, the ability to
derive accurate and informative insights requires more than the ability to
execute machine learning models. Rather, a deeper understanding of the data on
which the models are run is imperative for their success. While a significant
effort has been undertaken to develop models able to process the volume of data
obtained during the analysis of millions of digitalized patient records, it is
important to remember that volume represents only one aspect of the data. In
fact, drawing on data from an increasingly diverse set of sources, healthcare
data presents an incredibly complex set of attributes that must be accounted
for throughout the machine learning pipeline. This chapter focuses on
highlighting such challenges, and is broken down into three distinct
components, each representing a phase of the pipeline. We begin with attributes
of the data accounted for during preprocessing, then move to considerations
during model building, and end with challenges to the interpretation of model
output. For each component, we present a discussion around data as it relates
to the healthcare domain and offer insight into the challenges each may impose
on the efficiency of machine learning techniques.Comment: Healthcare Informatics, Machine Learning, Knowledge Discovery: 20
Pages, 1 Figur
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