FORMULASI DAN KARAKTERISASI EMULGEL EKSTRAK LIKOPEN TERPURIFIKASI DARI TOMAT (Solanum lycopersicum L) UNTUK ANTI KERUTAN

Penelitian tentang emulgel telah dilakukan untuk mengetahui pengaruh formulasi terhadap karakterisasi dan stabilitas emulgel likopen. Emulgel dibuat menggunakan likopen yang diperoleh dari hasil ekstraksi tomat (Solanum lycopersicum L) kemudian dikarakterisasi meliputi KLT (kromatografi lapis tipis), mikroskop yang dilengkapi dengan optilab®, fourier transformation infra red (FT-IR), difraksi sinar-X (XRD), dan differential scanning calorimetry (DSC). Untuk uji stabilitas emulgel digunakan analisis distribusi ukuran partikel dan freeze and thaw. Nilai Rf 0,38, penampakan bentuk kristal jarum. Spektrum FT-IR menunjukkan gugus fungsi O-H pada bilangan gelombang 3448,27 cm-1, CH pada 2920,85 cm-1, C=C pada 1654,24 cm-1, CH trans pada 1080,97 cm-1, dan R–CH=CH–R pada bilangan gelombang 720,23 cm-1. Termogram DSC menunjukkan pergeseran puncak endotermik pada 54,60 oC sedangkan pada literatur 109 oC. Difraktogram XRD berada pada puncak 2θ 21,4 o. Evaluasi emulgel meliputi pemeriksaan fisik, pH, tipe emulgel, uji sentrifugasi, pengukuran viskositas, distribusi ukuran partikel, uji stabilitas menggunakan freeze and thaw, dan uji efektivitas anti-kerutan menggunakan metode topografi. Formula memiliki pH 7,5, emulgel termasuk tipe minyak dalam air, tidak mengalami pemisahan fase, viskositas 15,7 cP, ukuran partikel 0-60 μm, sediaan stabil secara fisika karena tidak terjadi perubahan globul setelah 6 siklus dengan nilai P < 0,05. Penetapan kadar emulgel likopen dengan rata-rata 100,81% dengan % RSD ≤ 5.36 serta pengurangan kerutan terjadi setelah penggunaan emulgel selama 21 hari

FORMULATION AND STABILITY TEST OF CREAM FROM JUICE OF BELIMBING WULUH (AVERRHOA BILIMBI l.)

Research on cream formulations using starfruit (Averrhoa bilimbi L.)&nbsp; juice has been carried out to determine the effect of sodium lauryl sulfate on the physical stability of cream from starfruit juice. Carambola wealth as an active substance is made in cream with varying concentrations of sodium lauryl sulfate of 1%, 1.5%, 2%, and 2.5%. The evaluation was carried out in the form of organoleptic tests, homogeneity, cream type, pH, viscosity, centrifugation, and freeze-thaw. Data analysis was carried out using statistical tests using ANOVA which has a 95% confidence level (α = 0.05), the test is continued with the Tukey HSD test, and the analysis results show significant differences in each formula. The research results concluded that the higher the concentration of sodium lauryl sulfate as an emulsifying agent, the physical stability of the viscosity of the cream from starfruit juice increased

Solid Dispersion System Candesartan-cilexetil Mannitol Co-Grinding Method

Research on solid dispersion systems had been done to improve physicochemical characteristics and the dissolution rate of candesartan-cilexetil a had been conducted. Candesartan cilexetil is included in BCS (Biopharmaceutical Classification System) class II, which has low solubility and high permeability which causes poor absorption of drugs in the digestive tract. Solid dispersions were prepared through the grinding method using mannitol. The formula with 3 comparisons between candesartan-cilexetil and mannitol 1:1, 1:3, and 1:5. A mixture of physics of candesartan cilexetil-mannitol was made without a solid dispersions system which was 1:1 as a comparison. Solid dispersion formed was characterized by particle size distribution analysis, Fourier transforms infrared (FT-IR), X-ray diffraction, scanning electron microscopy (SEM), differential scanning calorimetry (DSC), determination rate, and dissolution test. The result particle size distribution analysis showed grinding method there were solid dispersions mixed perfectly. The FT-IR of this analysis showed no interaction between candesartan-cilexetil mannitol in solid dispersion powder. The result of X-ray diffraction showed a decrease in crystallization degree. The DSC result showed a shift in endothermic peak candesartan-cilexetil. The manufacture of a solid dispersion system of candesartan-cilexetil mannitol can improve the physicochemical characteristics and the dissolution rate of candesartan-cilexetil compared with physical mixtures. The result in the dissolution was solid dispersion 1 = 53.1990 %, solid dispersion 2 = 54.3621 %, and solid dispersion 3 = 62.3621 %. The statistical result of dissolution efficiency using the Kruskal-Willis test with significant = 0.009(< 0.05) showed the difference among the dissolution efficiency of candesartan-cilexetil, physical mixture, and each solid dispersion