Study of the performance of the NA62 Small-Angle Calorimeter at the DAΦ\PhiNE Linac

The measurement of $BR(K^+\to\pi^+\nu\bar{\nu})$ with 10% precision by the NA62 experiment requires extreme background suppression. The Small Angle Calorimeter aims to provide an efficient veto for photons flying at angles down to zero with respect to the kaon flight direction. The initial prototype was upgraded and tested at the Beam Test Facility of the DA$\Phi$NE Linac at Frascati. The energy resolution and the efficiency were measured and are presented.Comment: 5 pages, 7 figure

Time over threshold in the presence of noise

The time over threshold is a widely used quantity to describe signals from various detectors in particle physics. Its electronics implementation is straightforward and in this paper we present the studies of its behavior in the presence of noise. A unique comb-like structure was identified in the data for a first time and was explained and modeled successfully. The effects of that structure on the efficiency and resolution are also discussed.Comment: 6 pages, 8 figure

Ambiguity, Familiarity and Learning Behavior in the Adoption of ICT for Irrigation Management

Subjective behavior of decision makers (DMs) is paramount when modeling information and communication technology (ICT) adoption choices in irrigated agriculture. Here, efficient ICT aided irrigation plans often involve a certain degree of uncertainty, and differential attitudes toward it can cause uncoordinated actions between actors. Some DMs will implement ICT information, while others will not because they do not trust ICT reliability. This risks undermining the achievement of ICT benefits in terms of water saving at the irrigation district level. By distinguishing between differ ent sources of uncertainty, taking the form of risk and ambiguity, in the present paper, we developed a new decision model to assess the impact that subjective behavior and learning processes have on the efficiency of ICT-aided irrigation plans. A case study was selected to implement the model in simplified settings. The results revealed the potential of ambiguity to limit ICT information implemen tation and to hinder water governance. Implications mainly concern the development of uncertainty management policies to favor DMs becoming familiar with the new ICT with lower ambiguit

Cooperative Management of Ecosystem Services: Coalition Formation, Landscape Structure and Policies

A growing body of literature shows that full-cooperation among farmers to manage productive ecosystem services would yield gains with respect to uncoordinated approaches. The public good feature of these ecosystem services may, however, hinder the emergence of a cooperative solution at the landscape scale. In this paper, we introduce in a coalition formation game a spatially-explicit bioeconomic model of fruit pollination, where pollinaton depends on the distance to the choosen location of natural habitats. We analyse: (i) which coalitions are stable; (ii) what benefits they provide; (iii) how cooperation depends on the initial landscape structure; and (iv) how policy instruments affect cooperation. The theoretical model presents the rationality of cooperation but, due to the detailed heterogeneity and complex spatial interactions among farms, we use a numerical example to determine the stable coalitions. We find that only small coalitions are stable and that the benefits of cooperation decrease when the spatial autocorrelation of fruit tree covers increase. Policy instruments can increase the interest for cooperation but per-hectare payments and minimum participation rules may reduce the habitat area at the margin (by decreasing the stability of coalitions). Price premium for the coalition members increase the habitat area but its budget-effectiveness decreases as the spatial autocorrelation of fruit tree covers increase

The PADME experiment at LNF

The PADME experiment, approved by INFN at the end of 2015, aims to search for missing mass signals in the annihilation of positrons on a thin fixed target produced by invisible decays of the dark photon. The detector construction will be completed by the end of 2017 to be ready to run in spring of 2018. The collaboration aims at collecting about 1013 positron on target by the end of 2018 to reach a sensitivity down to 1 × 10−3 on the coupling of A′ up to 23.7 MeV mass

Effect of treatment of periodontitis on incretin axis in obese and non-obese individuals: A cohort study

CONTEXT: Periodontitis confers an increased risk of developing type 2 diabetes and, in patients with obesity, it might interfere with the incretin axis. The effect of periodontal treatment on glucoregulatory hormones remains unknown. OBJECTIVE: To evaluate the effect of periodontal treatment on incretin axis in obese and lean non-diabetic individuals. SETTING: King's College Dental Hospital and Institute, London, UK. PARTICIPANTS AND METHODS: The metabolic profile of obese and BMI-normal individuals affected by periodontitis was studied at baseline, 2 and 6 months after intensive periodontal treatment, by measuring plasma insulin, glucagon, GLP-1 and GIP and markers of systemic inflammation and oxidative stress. MAIN OUTCOME MEASURE(S): Circulating levels of incretins and inflammatory markers. RESULTS: At baseline, periodontal parameters were worse for obese than non-obese; this was accompanied by higher levels of circulating hs-CRP, insulin and GLP-1. The response to periodontal treatment was less favourable in the obese group, without significant variations of hs-CRP or malondialdehyde. Gluco-regulatory hormones changed differently after treatment: while insulin and glucagon did not vary at 2 and 6 months, GLP-1 and GIP significantly increased at 6 months in both groups. In particular, GLP-1 increased more rapidly in obese participants, while the increase of GIP followed similar trends across visits in both groups. CONCLUSIONS: Nonsurgical treatment of periodontitis is associated with increased GLP-1 and GIP levels in non-obese and obese patients; changes in GLP-1 were more rapid in obese participants. This might have positive implications for the metabolic risk of these individuals

Stemness Features in Liver Cancer

Heterogeneity is a cardinal hallmark of cancer, including primary liver cancer (PLC), and occurs at different layers including putative cell-of-origin. Current evidence suggests that within cellular subpopulations in PLC there are stem-like cells, the cancer stem cells (CSCs). The CSC concept has been recently proposed as an explanation of such intra-tumor heterogeneity. According to this model, CSCs are responsible for tumor initiation, recurrence, metastasis as well as drug-resistance. However, although the CSC hypothesis is intriguing and supported by a large number of experimental studies, there are still open questions regarding the origin of putative CSCs. Since chemo-resistance and recurrence represent major issues in PLC treatment, the development of new therapeutic strategies is needed, for which a good understanding of tumor behavior and in particular of CSCs biology is an imperative prerequisite. In this review we summarize the regulatory pathways that support CSC features in PLC. Moreover, we highlight the key features of hepatic CSC, in terms of enhanced drug-resistance, increased metastatic potential and metabolic rearrangement. Knowledge of the molecular mechanisms underlying CSC biology may provide novel options for PLC combination therapies

Sex-Specific Effects of Prenatal Stress on Bdnf Expression in Response to an Acute Challenge in Rats : a Role for Gadd45β

Exposure to early adversities represents a major risk factor for psychiatric disorders. We have previously shown that exposure to prenatal stress (PNS) in rats alters the developmental expression of brain-derived neurotrophic factor (Bdnf) with a specific temporal profile. However, exposure to early-life stress is known to alter the ability to cope with challenging events later in life, which may contribute to the enhanced vulnerability to stress-related disorders. Since Bdnf is also an important player for activity-dependent plasticity, we investigated whether the exposure to PNS in rats could alter Bdnf responsiveness to an acute challenge at adulthood. We found that exposure to PNS produces significant changes in Bdnf responsiveness with brain region- and gender-specific selectivity. Indeed, exposure to an acute stress upregulates Bdnf expression in the prefrontal cortex, but not in the hippocampus, of control animals. Moreover, such modulatory activity is selectively impaired in PNS female rats, an effect that was associated with changes in the modulation of the DNA demethylase Gadd45\u3b2. Our results suggest that exposure to PNS may reprogram gene transcription through epigenetic mechanisms reducing the ability to cope under adverse conditions, a trait that is disrupted in psychiatric diseases

Coronary age as a risk factor in the modified Framingham risk score

BACKGROUND: Clinical guidelines emphasize risk assessment as vital to patient selection for medical primary intervention. However, risk assessment methods are restricted in their ability to predict further coronary events. The most widely accepted tool in the United States is the Framingham risk score. In these equations age is a powerful risk factor. Although the extent of coronary atherosclerosis increases with age, there is large inter-individual variability in the rate of development and progression of this disease. This fact limits the utility of Framingham scoring when applied to individuals. Electron beam tomography (EBT), which measures coronary calcium, provides a non-invasive method for assessing coronary plaque burden, thus offering the possibility of providing a more accurate estimate of an individual's "arterial age" than from chronological age alone. METHODS: In this paper we discuss a new and simple method for incorporating the coronary calcium score (CCS) to modify the Framingham Risk Assessment (FRA). Using this method, a coronary artery calcium (CAC) age equivalent is generated that replaces chronological age in Framingham scoring. RESULTS AND DISCUSSION: Using a percentile table of CCS scores by age group and sex, individuals are matched to the age group whose calcium score most closely approximates their own individual score. The original 10-year absolute risk score of a 65-year old man with a CCS of 6 based on chronological age is 10%, whereas the modified absolute risk score based on CAC age equivalents is 2%. CONCLUSION: Our approach of replacing chronological age with CAC age equivalents in the Framingham equations possesses simplicity of application combined with precision. Physicians can easily derive adjusted Framingham risk scores and prescribe intervention methods based on patients' ten-year risks. The adjusted ten-year risks are likely to be more accurate than unadjusted risks since they are based on coronary calcium score information. The modified FRA approach not only may increase the predicted risk for some patients, but also may decrease the predicted risk for others, making it a more precise adjustment than other methods