Quantum Logical States and Operators for Josephson-like Systems

We give a formal algebraic description of Josephson-type quantum dynamical systems, i.e., Hamiltonian systems with a cos theta-like potential term. The two-boson Heisenberg algebra plays for such systems the role that the h(1) algebra does for the harmonic oscillator. A single Josephson junction is selected as a representative of Josephson systems. We construct both logical states (codewords) and logical (gate) operators in the superconductive regime. The codewords are the even and odd coherent states of the two-boson algebra: they are shift-resistant and robust, due to squeezing. The logical operators acting on the qubit codewords are expressed in terms of operators in the enveloping of the two-boson algebra. Such a scheme appears to be relevant for quantum information applications.Comment: 12 pages in RevTex. In press, Journal of Physics A/Letter

Evaluation and Expected Changes of Summer Precipitation at Convection Permitting Scale with COSMO-CLM over Alpine Space

There is an ongoing debate in the climate community about the benefits of convection-permitting models that explicitly resolve convection and other thermodynamical processes. An increasing number of studies show improvements in Regional Climate Model (RCM) performances when the grid spacing is increased to 1-km scale. Up until now, such studies have revealed that convection-permitting models confer significant advantages in representing orographic regions, producing high-order statistics, predicting events with small temporal and spatial scales, and representing convective organization. The focus of this work is on the analysis of summer precipitation over the Alpine space. More specifically, the driving data are downscaled using the RCM COSMO-CLM first at an intermediate resolution (12 km) over the European Domain of Coordinated Downscaling Experiment (EURO-CORDEX domain). Then, a further downscaling at 3 km, nested into the previous one, is performed over the Alpine domain to exploit the results over a complex orography context. Experiments of evaluation, historical and far future under the Intergovernmental Panel on Climate Change (IPCC) RCP8.5 scenario have been considered. Indices as mean precipitation, frequency, intensity, and heavy precipitation are employed in daily and hourly analyses. The results, observed from the analysis of 10 year-long simulations, provide preliminary indications, highlighting significant differences of the convection permitting simulations with respect to the driving one, especially at an hourly time scale. Moreover, future projections suggest that the convection permitting simulation refines and enhances the projected patterns, compared with the coarser resolution

Visualization of DNA G-quadruplexes in herpes simplex virus 1-infected cells

We have previously shown that clusters of guanine quadruplex (G4) structures can form in the human herpes simplex-1 (HSV-1) genome. Here we used immunofluorescence and immune-electron microscopy with a G4-specific monoclonal antibody to visualize G4 structures in HSV-1 infected cells. We found that G4 formation and localization within the cells was virus cycle dependent: viral G4s peaked at the time of viral DNA replication in the cell nucleus, moved to the nuclear membrane at the time of virus nuclear egress and were later found in HSV-1 immature virions released from the cell nucleus. Colocalization of G4s with ICP8, a viral DNA processing protein, was observed in viral replication compartments. G4s were lost upon treatment with DNAse and inhibitors of HSV-1 DNA replication. The notable increase in G4s upon HSV-1 infection suggests a key role of these structures in the HSV-1 biology and indicates new targets to control both the lytic and latent infection

Extracorporeal Shock Wave Treatment (ESWT) enhances the in vitro-induced differentiation of human tendon-derived stem/progenitor cells (hTSPCs)

Extracorporeal shock wave therapy (ESWT) is a non-invasive and innovative technology for the management of specific tendinopathies. In order to elucidate the ESWT-mediated clinical benefits, human Tendon-derived Stem/Progenitor cells (hTSPCs) explanted from 5 healthy semitendinosus (ST) and 5 ruptured Achilles (AT) tendons were established. While hTSPCs from the two groups showed similar proliferation rates and stem cell surface marker profiles, we found that the clonogenic potential was maintained only in cells derived from healthy donors. Interestingly, ESWT significantly accelerated hTSPCs differentiation, suggesting that the clinical benefits of ESWT may be ascribed to increased efficiency of tendon repair after injury

Structural and Vibro-Acoustics Optimization of a Car Body Rear Part

The perceived vibro-acoustic comfort, inside the passenger compartment, under driving conditions, is strictly related to the car body torsional behavior. The aim of this work was to identify which parts of a car body most influence the first torsional mode, in order to modify them and acquire an increase in such car body natural frequency. It was also intended to exploit the great potential of 3D printing that allows an increase in the complexity of component shapes, with an acceptable compromise with respect to production costs. A design and material (from steel to aluminum) change of a car body rear part, which was identified as the structural part of the car body with the most relevant impact on the frequency of the first torsional mode, was assessed in terms of structural and vibro-acoustic performances. In particular, with the constraint of increasing the structural and vibroacoustic performances and, at the same time, minimize the weight of the structure itself, geometric, structural (e.g., type of connections), and material changes of the car body rear part were assessed. Working on a car model dating back to 2008, which was already compliant with structural and vibro-acoustic regulatory norms, an increase of 2 Hz on the first torsional mode frequency of the Trimmed Body model was obtained. In parallel, a weight reduction in the optimized components was also gained. It was also requested to lower the cabin sound pressure levels, optimizing the vibro-acoustic transfer functions from the accelerations at engine mounts and suspension attachment points to the cabin inside. It was shown how the combined use of advanced topological and structural optimization tools, with the capabilities of an unconventional manufacturing technology, such as 3D printing in aluminum, could guarantee an increase in the vibro-acoustics and structural car performances, also gaining a weight reduction

pH-Responsive Polyketone/5,10,15,20-Tetrakis-(Sulfonatophenyl)Porphyrin Supramolecular Submicron Colloidal Structures

In this work, we prepared color-changing colloids by using the electrostatic self-assembly approach. The supramolecular structures are composed of a pH-responsive polymeric surfactant and the water-soluble porphyrin 5,10,15,20-tetrakis-(sulfonatophenyl)porphyrin (TPPS). The pH-responsive surfactant polymer was achieved by the chemical modification of an alternating aliphatic polyketone (PK) via the Paal-Knorr reaction with N-(2-hydroxyethyl)ethylenediamine (HEDA). The resulting polymer/dye supramolecular systems form colloids at the submicron level displaying negative zeta potential at neutral and basic pH, and, at acidic pH, flocculation is observed. Remarkably, the colloids showed a gradual color change from green to pinky-red due to the protonation/deprotonation process of TPPS from pH 2 to pH 12, revealing different aggregation behavior

Echocardiography to estimate high filling pressure in patients with heart failure and reduced ejection fraction

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