505 research outputs found
The Gaze Fixation Assessed by Microperimetry : A Useful Tool for the Monitoring of the Cognitive Function in Patients with Type 2 Diabetes
Current guidelines recommend annual screening for cognitive impairment in patients > 65 years with type 2 diabetes (T2D). The most used tool is the mini-mental state evaluation (MMSE). Retinal microperimetry is useful for detecting cognitive impairment in these patients, but there is no information regarding its usefulness as a monitoring tool. We aimed to explore the role of retinal microperimetry in the annual follow-up of the cognitive function of patients with T2D older than 65 years. Materials and Methods: Prospective observational study, comprising patients > 65 years with T2D, attended at our center between March-October 2019. A complete neuropsychological evaluation assessed the baseline cognitive status (mild cognitive impairment, MCI, or normal, NC). Retinal microperimetry (sensitivity, gaze fixation) and MMSE were performed at baseline and after 12 months. Results: Fifty-nine patients with MCI and 22 NC were identified. A significant decline in the MMSE score was observed after 12 months in the MCI group (25.74 ± 0.9 vs. 24.71 ± 1.4; p = 0.001). While no significant changes in retinal sensitivity were seen, all gaze-fixation parameters worsened at 12 months and significantly correlated with a decrease in the MMSE scores. Conclusion: Retinal microperimetry is useful for the monitoring of cognitive decline in patients > 65 years with T2D. Gaze fixation seems a more sensitive parameter for follow-up after 12 months than retinal sensitivity
The Gaze Fixation Assessed by Microperimetry: A Useful Tool for the Monitoring of the Cognitive Function in Patients with Type 2 Diabetes
Cognitive impairment; Retinal microperimetry; Type 2 diabetesDeterioro cognitivo; Microperimetría retiniana; Diabetes tipo 2Deteriorament cognitiu; Microperimetria retiniana; Diabetis tipus 2Current guidelines recommend annual screening for cognitive impairment in patients > 65 years with type 2 diabetes (T2D). The most used tool is the mini-mental state evaluation (MMSE). Retinal microperimetry is useful for detecting cognitive impairment in these patients, but there is no information regarding its usefulness as a monitoring tool. We aimed to explore the role of retinal microperimetry in the annual follow-up of the cognitive function of patients with T2D older than 65 years. Materials and Methods: Prospective observational study, comprising patients > 65 years with T2D, attended at our center between March–October 2019. A complete neuropsychological evaluation assessed the baseline cognitive status (mild cognitive impairment, MCI, or normal, NC). Retinal microperimetry (sensitivity, gaze fixation) and MMSE were performed at baseline and after 12 months. Results: Fifty-nine patients with MCI and 22 NC were identified. A significant decline in the MMSE score was observed after 12 months in the MCI group (25.74 ± 0.9 vs. 24.71 ± 1.4; p = 0.001). While no significant changes in retinal sensitivity were seen, all gaze-fixation parameters worsened at 12 months and significantly correlated with a decrease in the MMSE scores. Conclusion: Retinal microperimetry is useful for the monitoring of cognitive decline in patients > 65 years with T2D. Gaze fixation seems a more sensitive parameter for follow-up after 12 months than retinal sensitivity.This study was supported by grants from the Instituto de Salud Carlos III (Fondo de Investigación Sanitaria, PI20/01703). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
EPOCHS VII: Discovery of high redshift () AGN candidates in JWST ERO and PEARLS data
We present an analysis of a sample of robust high redshift galaxies selected
photometrically from the `blank' fields of the Prime Extragalactic Areas for
Reionization Science (PEARLS) survey and Early Release Observations (ERO) data
of the James Webb Space Telescope (JWST) with the aim of selecting candidate
high redshift active galactic nuclei (AGN). Sources were identified from the
parent sample using a threefold selection procedure, which includes spectral
energy distribution (SED) fitting to identify sources that are best fitted by
AGN SED templates, a further selection based on the relative performance of AGN
and non-AGN models, and finally morphological fitting to identify compact
sources of emission, resulting in a purity-oriented procedure. Using this
procedure, we identify a sample of nine AGN candidates at , from
which we constrain their physical properties as well as measure a lower bound
on the AGN fraction in this redshift range of \%. As this is an
extreme lower limit due to our focus on purity and our SEDs being calibrated
for unobscured Type 1 AGN, this demonstrates that AGN are perhaps quite common
at this early epoch. The rest-frame UV colors of our candidate objects suggest
that these systems are potentially candidate obese black hole galaxies (OBG),
or AGN with very little galaxy component. We also investigate emission from our
sample sources from fields overlapping with Chandra and VLA surveys, allowing
us to place X-ray and 3 GHz radio detection limits on our candidates. Of note
is a candidate source exhibiting an abrupt morphological shift in
the reddest band as compared to the bluer bands, indicating a potential merger
or an unusually strong outflow.Comment: Submitted to MNRAS, 12 pages, 11 figures, typos correcte
JWST's PEARLS: Improved Flux Calibration for NIRCam
The Prime Extragalactic Areas for Reionization and Lensing Science (PEARLS),
a JWST GTO program, obtained a set of unique NIRCam observations that have
enabled us to significantly improve the default photometric calibration across
both NIRCam modules. The observations consisted of three epochs of 4-band
(F150W, F200W, F356W, and F444W) NIRCam imaging in the Spitzer IRAC Dark Field
(IDF). The three epochs were six months apart and spanned the full duration of
Cycle 1. As the IDF is in the JWST continuous viewing zone, we were able to
design the observations such that the two modules of NIRCam, modules A and B,
were flipped by 180 degrees and completely overlapped each other's footprints
in alternate epochs. We were therefore able to directly compare the photometry
of the same objects observed with different modules and detectors, and we found
significant photometric residuals up to ~ 0.05 mag in some detectors and
filters, for the default version of the calibration files that we used
(jwst_1039.pmap). Moreover, there are multiplicative gradients present in the
data obtained in the two long-wavelength bands. The problem is less severe in
the data reduced using the latest pmap (jwst_1130.pmap as of September 2023),
but it is still present, and is non-negligible. We provide a recipe to correct
for this systematic effect to bring the two modules onto a more consistent
calibration, to a photometric precision better than ~ 0.02 mag.Comment: 12 pages, 8 figures, 3 tables. Accepted to PAS
Magellanic System Stars Identified in the SMACS J0723.3-7327 JWST ERO Images
We identify 68 distant stars in JWST/NIRCam ERO images of the field of galaxy
cluster SMACS J0723.3-7327 (SMACS 0723). Given the relatively small
() angular separation between SMACS 0723 and the Large
Magellanic Cloud, it is likely that these stars are associated with the LMC
outskirts or Leading Arm. This is further bolstered by a spectral energy
distribution analysis, which suggests an excess of stars at a physical distance
of kpc, consistent with being associated with or located behind the
Magellanic system. In particular, we find that the overall surface density of
stars brighter than 27.0 mag in the field of SMACS 0723 is 2.3 times that
of stars in a blank field with similar galactic latitude (the North Ecliptic
Pole Time Domain Field), and that the density of stars in the SMACS 0723 field
with SED-derived distances consistent with the Magellanic system is 7.3
times larger than that of the blank field. The candidate stars at these
distances are consistent with a stellar population at the same distance modulus
with [Fe/H] and an age of Gyr. On the assumption that all
of the 68 stars are associated with the LMC, then the stellar density of the
LMC at the location of the SMACS 0723 field is stars kpc,
which helps trace the density of stars in the LMC outskirts.Comment: Submitted to ApJ, comments welcom
PEARLS: A Potentially Isolated Quiescent Dwarf Galaxy with a TRGB Distance of 31 Mpc
A wealth of observations have long suggested that the vast majority of
isolated classical dwarf galaxies (- M) are currently
star-forming. However, recent observations of the large abundance of
"Ultra-Diffuse Galaxies" beyond the reach of previous large spectroscopic
surveys suggest that our understanding of the dwarf galaxy population may be
incomplete. Here we report the serendipitous discovery of an isolated quiescent
dwarf galaxy in the nearby Universe, which was imaged as part of the PEARLS GTO
program. Remarkably, individual red-giant branch stars are visible in this
near-IR imaging, suggesting a distance of Mpc, and a wealth of archival
photometry point to an sSFR of yr. Spectra obtained
with the Lowell Discovery Telescope find a recessional velocity consistent with
the Hubble Flow and km/s separated from the nearest massive galaxy in
SDSS, suggesting that this galaxy was either quenched from internal mechanisms
or had a very high-velocity interaction with a nearby massive galaxy in the
past. This analysis highlights the possibility that many nearby quiescent dwarf
galaxies are waiting to be discovered and that JWST has the potential to
identify them.Comment: Submitted to ApJ Letters. Comments welcome
JWST's PEARLS: 119 multiply imaged galaxies behind MACS0416, lensing properties of caustic crossing galaxies, and the relation between halo mass and number of globular clusters at
We present a new lens model for the galaxy cluster MACS
J0416.12403 based on a previously known set of 77 spectroscopically
confirmed, multiply imaged galaxies plus an additional set of 42 candidate
multiply imaged galaxies from past HST and new JWST data. The new galaxies lack
spectroscopic redshifts but have geometric and/or photometric redshift
estimates that are presented here. The new model predicts magnifications and
time delays for all multiple images. The full set of constraints totals 343,
constituting the largest sample of multiple images lensed by a single cluster
to date. Caustic-crossing galaxies lensed by this cluster are especially
interesting. Some of these galaxies show transient events, most of which are
interpreted as micro-lensing of stars at cosmological distances. These
caustic-crossing arcs are expected to show similar events in future, deeper
JWST observations. We provide time delay and magnification models for all these
arcs. The time delays and the magnifications for different arcs are generally
anti-correlated, as expected from -body simulations.
In the major sub-halos of the cluster, the dark-matter mass from our lens
model correlates well with the observed number of globular clusters. This
confirms earlier results, derived at lower redshifts, which suggest that
globular clusters can be used as powerful mass proxies for the halo masses when
lensing constraints are scarce or not available.Comment: 21 pages and 11 figure
The JWST Discovery of the Triply-imaged Type Ia "Supernova H0pe" and Observations of the Galaxy Cluster PLCK G165.7+67.0
A Type Ia supernova (SN) at was discovered in James Webb Space
Telescope Near Infrared Camera imaging of the galaxy cluster PLCK G165.7+67.0
(G165; ). The SN is situated 1.5-2kpc from its host galaxy Arc 2 and
appears in three different locations as a result of gravitational lensing by
G165. These data can yield a value for Hubble's constant using time delays from
this multiply-imaged SN Ia that we call "SN H0pe." Over the entire field we
identified 21 image multiplicities, confirmed five of them using Near-Infrared
Spectrograph (NIRspec), and constructed a new lens model that gives a total
mass within 600kpc of ( M. The
photometry uncovered a galaxy overdensity at Arc 2's redshift. NIRSpec
confirmed six member galaxies, four of which surround Arc 2 with relative
velocity 900 km s and projected physical extent 33
kpc. Arc 2 dominates the stellar mass (
M), which is a factor of ten higher than other members of this
compact galaxy group. These other group members have specific star formation
rates (sSFR) of 2-260Gyr derived from the H-line flux corrected
for stellar absorption, dust extinction, and slit losses. Another group
centered on the dusty star forming galaxy Arc 1 is at . The total SFR
for the Arc 1 group ( M yr) translates to a supernova
rate of 1 SNe yr, suggesting that regular monitoring of this
cluster may yield additional SNe.Comment: 27 pages, submitted to Ap
Magellanic system stars identified in SMACS J0723.3-7327 James Webb Space Telescope early release observations images
We identify 71 distant stars in James Webb Space Telescope/NIRCam early release observations (ERO) images of the field of galaxy cluster SMACS J0723.3-7327 (SMACS 0723). Given the relatively small (∼10°) angular separation between SMACS 0723 and the Large Magellanic Cloud (LMC), it is likely that these stars are associated with the LMC outskirts or the Leading Arm. This is further bolstered by a spectral energy distribution (SED) analysis, which suggests an excess of stars at a physical distance of 40–100 kpc, consistent with being associated with or located behind the Magellanic system. In particular, we find that the overall surface density of stars brighter than 27.0 mag in the field of SMACS 0723 is ∼2.3 times that of stars in a blank field with similar Galactic latitude (the North Ecliptic Pole Time Domain Field), and that the density of stars in the SMACS 0723 field with SED-derived distances consistent with the Magellanic system is ∼6.1 times larger than that of the blank field. The candidate stars at these distances are consistent with a stellar population at the same distance modulus with [Fe/H] = −1.0 and an age of ∼5.0 Gyr. On the assumption that all of the 71 stars are associated with the LMC, then the stellar density of the LMC at the location of the SMACS 0723 field is ∼740 stars kpc−3, which helps trace the density of stars in the LMC outskirts.J.S. acknowledges support from an undergraduate Arizona NASA Space Grant, Cooperative Agreement 80NSSC20M0041. R.A.W., S.H.C., and R.A.J. acknowledge
support from NASA JWST Interdisciplinary Scientist grants NAG5-12460, NNX14AN10G and 80NSSC18K0200 from GSFC. C.J.C. and N.J.A. acknowledge support from the
European Research Council (ERC) Advanced Investigator Grant EPOCHS (788113). M.A.M. acknowledges the support of a National Research Council of Canada Plaskett Fellowship, and the Australian Research Council Centre of Excellence for All Sky Astrophysics in 3 Dimensions (ASTRO 3D), through project number CE17010001. C.N.A.W. acknowledges funding from the JWST/NIRCam contract NASS-0215 to the
University of Arizona. This work is based on observations made with the NASA/ESA/CSA James Webb Space Telescope. The data were obtained from the Mikulski Archive for Space Telescopes (MAST) at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127 for JWST. These observations are associated with JWST programs 1176, 2736, and 2738. All of the JWST data used in this paper can be found on doi:10.17909/b7hf-he53. This work is based on observations taken by the RELICS Treasury Program (Coe 2016, GO 14096) with the NASA/ESA HST, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555. This work has made use of data from the European Space Agency (ESA) mission Gaia (https://www.cosmos.esa.int/gaia), processed by the Gaia Data Processing and Analysis Consortium (DPAC, https://www.cosmos.esa.int/web/gaia/dpac/consortium).
Funding for the DPAC has been provided by national institutions, in particular the institutions participating in the Gaia Multilateral Agreement. We also acknowledge the JWST ERO team responsible for providing these products.Peer reviewe
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PEARLS: A potentially isolated quiescent dwarf galaxy with a tip of the red giant branch distance of 30 Mpc
A wealth of observations have long suggested that the vast majority of isolated classical dwarf galaxies (M* = 107–109M⊙) are currently star forming. However, recent observations of the large abundance of "ultra-diffuse galaxies" beyond the reach of previous large spectroscopic surveys suggest that our understanding of the dwarf galaxy population may be incomplete. Here we report the serendipitous discovery of an isolated quiescent dwarf galaxy in the nearby Universe, which was imaged as part of the JWST PEARLS Guaranteed Time Observation program. Remarkably, individual red-giant branch stars are visible in this near-IR imaging, suggesting a distance of 30 ± 4 Mpc, and a wealth of archival photometry point to an sSFR of 2 × 10−11 yr−1 and star formation rate of 4 × 10−4M⊙ yr−1. Spectra obtained with the Lowell Discovery Telescope find a recessional velocity consistent with the Hubble Flow and >1500 km s−1 separated from the nearest massive galaxy in Sloan Digital Sky Survey suggesting that this galaxy was either quenched from internal mechanisms or had a very high-velocity (≳1000 km s−1) interaction with a nearby massive galaxy in the past. This analysis highlights the possibility that many nearby quiescent dwarf galaxies are waiting to be discovered and that JWST has the potential to resolve them.T.M.C. is grateful for support from the Beus Center for Cosmic Foundations. R.A.W., S.H.C., and R.A.J. acknowledge support from NASA JWST Interdisciplinary Scientist grants NAG5-12460, NNX14AN10G and 80NSSC18K0200 from GSFC. J.M.D. acknowledges the support of project PGC2018-101814-B-100 (MCIU/AEI/MINECO/FEDER, UE) Ministerio de Ciencia, Investigación y Universidades. This project was funded by the Agencia Estatal de Investigación, Unidad de Excelencia María de Maeztu, ref. MDM-2017-0765. C.C. is supported by the National Natural Science Foundation of China, Nos. 11803044, 11933003, 12173045. This work is sponsored (in part) by the Chinese Academy of Sciences (CAS), through a grant to the CAS South America Center for Astronomy (CASSACA). We acknowledge the science research grants from the China Manned Space Project with No. CMS-CSST-2021-A05. R.A.B. gratefully acknowledges support from the European Space Agency (ESA) Research Fellowship. C.J.C. acknowledges support from the European Research Council (ERC) Advanced Investigator Grant EPOCHS (788113). C.N.A.W. acknowledges funding from the JWST/NIRCam contract NASS-0215 to the University of Arizona. M.A.M. acknowledges the support of a National Research Council of Canada Plaskett Fellowship, and the Australian Research Council Centre of Excellence for All Sky Astrophysics in 3 Dimensions (ASTRO 3D), through project number CE17010001.Peer reviewe
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