Defense and Attack Techniques against File-based TOCTOU Vulnerabilities: a Systematic Review

File-based Time-of-Check to Time-of-Use (TOCTOU) race conditions are a well-known type of security vulnerability. A wide variety of techniques have been proposed to detect, mitigate, avoid, and exploit these vulnerabilities over the past 35 years. However, despite these research efforts, TOCTOU vulnerabilities remain unsolved due to their non-deterministic nature and the particularities of the different filesystems involved in running vulnerable programs, especially in Unix-like operating system environments. In this paper, we present a systematic literature review on defense and attack techniques related to the file-based TOCTOU vulnerability. We apply a reproducible methodology to search, filter, and analyze the most relevant research proposals to define a global and understandable vision of existing solutions. The results of this analysis are finally used to discuss future research directions that can be explored to move towards a universal solution to this type of vulnerability. Autho

RECENT ORTHOPHOTOMAPS REQUIRED IN FOREST MANAGEMENT WORK USING DRONES

The research carried out in the framework of the forest fund public property of the state, uses the advantages of drones in obtaining the data and information required for the forest area concerned in the construction of the forests in Romania. Data and information obtained as a result of the flight with drones-UAV chosen in three locations under distinct geomorphological characteristics, contribute to the methodology of work with the instruments flight without pilot (drones) in the forestry field. The products obtained by processing images acquired airlines with flight without pilot (drones): the cloud of points and 3Dmesh, the digital model of the surface (DSM) and orthophotomaps, can contribute to the completion of the landscapedatabase supplied to the development of forestry management plan. At the same time, the orthophotomap obtained from aerial image processing taken with unmanned aircraft (drones) contributes to the process of updating the cartographic basis required for forest planning. Preliminary analysis of the orthofotomaps obtained, regarding the elements of interest for the forest vegetation can assist the activity of forestry structures and public authority in the field, in sustainable forest management by: ensure the integrity of the forest fund and permanence of the forest, ensure the adequacy of the legal continuity, institutional and operational in the forest management, the identification of the necessary work to prevent and control pests and diseases of the forest, the monitoring of the areas affected by destabilizing factors

SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development

Skp1‐Cul1‐F‐box protein (SCF) ubiquitin ligases direct cell survival decisions by controlling protein ubiquitylation and degradation. Sufu (Suppressor of fused) is a central regulator of Hh (Hedgehog) signaling and acts as a tumor suppressor by maintaining the Gli (Glioma‐associated oncogene homolog) transcription factors inactive. Although Sufu has a pivotal role in Hh signaling, the players involved in controlling Sufu levels and their role in tumor growth are unknown. Here, we show that Fbxl17 (F‐box and leucine‐rich repeat protein 17) targets Sufu for proteolysis in the nucleus. The ubiquitylation of Sufu, mediated by Fbxl17, allows the release of Gli1 from Sufu for proper Hh signal transduction. Depletion of Fbxl17 leads to defective Hh signaling associated with an impaired cancer cell proliferation and medulloblastoma tumor growth. Furthermore, we identify a mutation in Sufu, occurring in medulloblastoma of patients with Gorlin syndrome, which increases Sufu turnover through Fbxl17‐mediated polyubiquitylation and leads to a sustained Hh signaling activation. In summary, our findings reveal Fbxl17 as a novel regulator of Hh pathway and highlight the perturbation of the Fbxl17–Sufu axis in the pathogenesis of medulloblastoma

A double homozygous mutation in the POMT1 gene involving exon skipping gives rise to Walker-Warburg syndrome in two Spanish gypsy families

Carta al editor.-- El pdf es la versión post-print sin figuras.-- et al.This work was supported by the Spanish Fondo de Investigaciones Sanitarias’ grant PI06/0378.Peer Reviewe

Platelet Rich Plasma- mechanism of action and clinical applications

Platelet-rich plasma (PRP) is a blood-derived fraction containing high level of platelets, a high concentration of leukocytes and growth factors. PRP therapy has been growing as a viable treatment alternative for a number of clinical applications and has a potential benefit for use in wound healing. Nowadays platelet rich plasma is used in stimulating wound healing in skin and soft tissue ulcerations, accelerating wound healing in diabetic patients and facilitating bone proliferation in orthopedic and trauma surgery. It has also applications in maxillofacial surgery, spinal surgery, plastic and esthetic surgery, heart surgery and burns. This review of the literature shows a limited number of studies realized on humans that sustain PRP applications in orthopedic and plastic surgery. As the use of PRP increases, more properly structured clinical studies are necessary to confirm the results and to establish clearly the techniques of preparing, the conditions and the clinical indications of applying this therapy

Clinical features and molecular characterization of a patient with muscle-eye-brain disease: A novel mutation in the POMGNT1 gene

Muscle-eye-brain disease is a congenital muscular dystrophy characterized by structural brain and eye defects. Here, we describe a 12-year-old boy with partial agenesis of corpus callosum, ventriculomegaly, flattened brain stem, diffuse pachygyria, blindness, profound cognitive deficiencies, and generalized muscle weakness, yet without a clear dystrophic pattern on muscle biopsy. There was no glycosylation of α-dystroglycan and the genetic screening revealed a novel truncating mutation, c.1545delC (p.Tyr516Thrfs*21), and a previously identified missense mutation, c.1469G>A (p.Cys490Tyr), in the protein O-mannose beta-1,2-N-acetylglucosaminyltransferase 1 (POMGNT1) gene. These findings broaden the clinical spectrum of muscle-eye-brain disease to include pronounced hypotonia with severe brain and eye malformations, yet with mild histopathologic changes in the muscle specimen, despite the absence of glycosylated α-dystroglycan.Peer Reviewe