1,414 research outputs found
Multi-scale mapping along the auditory hierarchy using high-resolution functional UltraSound in the awake ferret
A major challenge in neuroscience is to longitudinally monitor whole brain activity across multiple spatial scales in the same animal. Functional UltraSound (fUS) is an emerging technology that offers images of cerebral blood volume over large brain portions. Here we show for the first time its capability to resolve the functional organization of sensory systems at multiple scales in awake animals, both within small structures by precisely mapping and differentiating sensory responses, and between structures by elucidating the connectivity scheme of top-down projections. We demonstrate that fUS provides stable (over days), yet rapid, highly-resolved 3D tonotopic maps in the auditory pathway of awake ferrets, thus revealing its unprecedented functional resolution (100/300”m). This was performed in four different brain regions, including very small (1â2 mm3 size), deeply situated subcortical (8 mm deep) and previously undescribed structures in the ferret. Furthermore, we used fUS to map long-distance projections from frontal cortex, a key source of sensory response modulation, to auditory cortex
Workload accomplished in phase III cardiac rehabilitation
Exercise training is an important component of clinical exercise programs. Although there are recognized guidelines for the amount of exercise to be accomplished (â„70,000 steps per week or â„150 min per week at moderate intensity), there is virtually no documentation of how much exercise is actually accomplished in contemporary exercise programs. Having guidelines without evidence of whether they are being met is of limited value. We analyzed both the weekly step count and the session rating of perceived exertion (sRPE) of patients (n = 26) enrolled in a community clinical exercise (e.g., Phase III) program over a 3-week reference period. Step counts averaged 39,818 ± 18,612 per week, with 18% of the steps accomplished in the program and 82% of steps accomplished outside the program. Using the sRPE method, inside the program, the patients averaged 162.4 ± 93.1 min per week, at a sRPE of 12.5 ± 1.9 and a frequency of 1.8 ± 0.7 times per week, for a calculated exercise load of 2042.5 ± 1244.9 AU. Outside the program, the patients averaged 144.9 ± 126.4 min, at a sRPE of 11.8 ± 5.8 and a frequency of 2.4 ± 1.5 times per week, for a calculated exercise load of 1723.9 ± 1526.2 AU. The total exercise load using sRPE was 266.4 ± 170.8 min per week, at a sRPE of 12.6 ± 3.8, and frequency of 4.2 ± 1.1 times per week, for a calculated exercise load of 3359.8 ± 2145.9 AU. There was a non-linear relationship between steps per week and the sRPE derived training load, apparently attributable to the amount of non-walking exercise accomplished in the program. The results suggest that patients in a community clinical exercise program are achieving American College of Sports Medicine guidelines, based on the sRPE method, but are accomplishing less steps than recommended by guidelines
PSS52 Safety in National Care - Real World Data from the German Psoriasis-Registry âPsobestâ
Theory of the c-Axis Penetration Depth in the Cuprates
Recent measurements of the London penetration depth tensor in the cuprates
find a weak temperature dependence along the c-direction which is seemingly
inconsistent with evidence for d-wave pairing deduced from in-plane
measurements. We demonstrate in this paper that these disparate results are not
in contradiction, but can be explained within a theory based on incoherent
quasiparticle hopping between the CuO2 layers. By relating the calculated
temperature dependence of the penetration depth \lambda_c(T) to the c-axis
resistivity, we show how the measured ratio \lambda_c^2(0) / \lambda_c^2(T) can
provide insight into the behavior of c-axis transport below Tc and the related
issue of ``confinement.''Comment: 4 pages, REVTEX with psfig, 3 PostScript figures included in
compressed for
The Effect of Surfaces on the Tunneling Density of States of an Anisotropically Paired Superconductor
We present calculations of the tunneling density of states in an
anisotropically paired superconductor for two different sample geometries: a
semi-infinite system with a single specular wall, and a slab of finite
thickness and infinite lateral extent. In both cases we are interested in the
effects of surface pair breaking on the tunneling spectrum. We take the stable
bulk phase to be of symmetry. Our calculations are performed
within two different band structure environments: an isotropic cylindrical
Fermi surface with a bulk order parameter of the form ,
and a nontrivial tight-binding Fermi surface with the order parameter structure
coming from an anti-ferromagnetic spin-fluctuation model. In each case we find
additional structures in the energy spectrum coming from the surface layer.
These structures are sensitive to the orientation of the surface with respect
to the crystal lattice, and have their origins in the detailed form of the
momentum and spatial dependence of the order parameter. By means of tunneling
spectroscopy, one can obtain information on both the anisotropy of the energy
gap, |\Delta(\p)|, as well as on the phase of the order parameter,
\Delta(\p) = |\Delta(\p)|e^{i\varphi(\p)}.Comment: 14 pages of revtex text with 11 compressed and encoded figures. To
appear in J. Low Temp. Phys., December, 199
Superconducting Order Parameter Symmetry in Multi-layer Cuprates
We discuss the allowed order parameter symmetries in multi-layer cuprates and
their physical consequences using highly non-specific forms of the inter- and
intra-plane interactions. Within this framework, the bi-layer case is discussed
in detail with particular attention paid to the role of small orthorhombic
distortions as would derive from the chains in YBCO or superlattice effects in
BSCCO. In the orthorhombic bi-layer case the (s,-s) state is of special
interest, since for a wide range of parameters this state exhibits pi phase
shifts in corner Josephson junction experiments. In addition, its transition
temperature is found to be insensitive to non-magnetic inter-plane disorder, as
would be present at the rare earth site in YBCO, for example. Of particular
interest, also, are the role of van Hove singularities which are seen to
stabilize states with d_{x^2 - y^2}-like symmetry, (as well as nodeless
s-states) and to elongate the gap functions along the four van Hove points,
thereby leading to a substantial region of gaplessness. We find that d_{x^2 -
y^2}-like states are general solutions for repulsive interactions; they possess
the fewest number of nodes and therefore the highest transition temperatures.
In this way, they should not be specifically associated with a spin fluctuation
driven pairing mechanism.Comment: REVTeX documentstyle, 34 pages, 10 figures include
On the c-axis optical reflectivity of layered cuprate superconductors
Using a conventional BCS -- Fermi liquid model we calculate the c-axis
optical reflectivity of the layered high temperature cuprate superconductors by
obtaining the finite temperature dynamical dielectric function in a microscopic
self-consistent gauge invariant formalism. We get good semi-quantitative
agreement with all the existing experimental data by using the measured normal
state resistivities as the input parameters in obtaining the c-axis
hopping amplitude and the normal state level broadening in our microscopic
calculation.Comment: 10 pages, 6 figures, 1 table gzipped tar fil
Prediction of exercise capacity and training prescription from the 6-minute walk test and rating of perceived exertion
Walking tests, such as the 6-min walk test (6MWT), are popular methods of estimating peak oxygen uptake (VO(2)peak) in clinical populations. However, the strength of the distance vs. VO(2)peak relationship is not strong, and there are no equations for estimating ventilatory threshold (VT), which is important for training prescription and prognosis. Since the 6MWT is often limited by walking mechanics, prediction equations that include simple additional predictors, such as the terminal rating of perceived exertion (RPE), hold the potential for improving the prediction of VO(2)max and VT. Therefore, this study was designed to develop equations for predicting VO(2)peak and VT from performance during the 6MWT, on the basis of walking performance and terminal RPE. Clinically stable patients in a cardiac rehabilitation program (N = 63) performed the 6MWT according to the American Thoracic Society guidelines. At the end of each walk, the subject provided their terminal RPE on a 6â20 Borg scale. Each patient also performed a maximal incremental treadmill test with respiratory gas exchange to measure VO(2)peak and VT. There was a good correlation between VO(2)peak and 6MWT distance (r = 0.80) which was improved by adding the terminal RPE in a multiple regression formula (6MWT + RPE, R(2) = 0.71, standard error of estimate, SEE = 1.3 Metabolic Equivalents (METs). The VT was also well correlated with walking performance, 6MWT distance (r = 0.80), and was improved by the addition of terminal RPE (6MWT + RPE, R(2) = 0.69, SEE = 0.95 METs). The addition of terminal RPE to 6MWT distance improved the prediction of maximal METs and METs at VT, which may have practical applications for exercise prescription
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