Thrombocytogenesis by megakaryocyte; Interpretation by protoplatelet hypothesis

Serial transmission electron microscopy of human megakaryocytes (MKs) revealed their polyploidization and gradual maturation through consecutive transition in characteristics of various organelles and others. At the beginning of differentiation, MK with ploidy 32N, e.g., has 16 centrosomes in the cell center surrounded by 32N nucleus. Each bundle of microtubules (MTs) emanated from the respective centrosome supports and organizes 16 equally volumed cytoplasmic compartments which together compose one single 32N MK. During the differentiation, single centriole separated from the centriole pair, i.e., centrosome, migrates to the most periphery of the cell through MT bundle, corresponding to a half of the interphase array originated from one centrosome, supporting one “putative cytoplasmic compartment” (PCC). Platelet demarcation membrane (DM) is constructed on the boundary surface between neighbouring PCCs. Matured PCC, composing of a tandem array of platelet territories covered by a sheet of DM is designated as protoplatelet. Eventually, the rupture of MK results in release of platelets from protoplatelets

Consensus Report : 2nd European Workshop on Tobacco Use Prevention and Cessation for Oral Health Professionals

Tobacco use has been identified as a major risk factor for oral disorders such as cancer and periodontal disease. Tobacco use cessation (TUC) is associated with the potential for reversal of precancer, enhanced outcomes following periodontal treatment, and better periodontal status compared to patients who continue to smoke. Consequently, helping tobacco users to quit has become a part of both the responsibility of oral health professionals and the general practice of dentistry. TUC should consist of behavioural support, and if accompanied by pharmacotherapy, is more likely to be successful. It is widely accepted that appropriate compensation of TUC counselling would give oral health professionals greater incentives to provide these measures. Therefore, TUC-related compensation should be made accessible to all dental professionals and be in appropriate relation to other therapeutic interventions. International and national associations for oral health professionals are urged to act as advocates to promote population, community and individual initiatives in support of tobacco use prevention and cessation (TUPAC) counselling, including integration in undergraduate and graduate dental curricula. In order to facilitate the adoption of TUPAC strategies by oral health professionals, we propose a level of care model which includes 1) basic care: brief interventions for all patients in the dental practice to identify tobacco users, assess readiness to quit, and request permission to re-address at a subsequent visit, 2) intermediate care: interventions consisting of (brief) motivational interviewing sessions to build on readiness to quit, enlist resources to support change, and to include cessation medications, and 3) advanced care: intensive interventions to develop a detailed quit plan including the use of suitable pharmacotherapy. To ensure that the delivery of effective TUC becomes part of standard care, continuing education courses and updates should be implemented and offered to all oral health professionals on a regular basis

Gaia uncovers difference in B and Be star binarity at small scales: evidence for mass transfer causing the Be phenomenon

Be stars make up almost 20 per cent of the B star population, and are rapidly rotating stars surrounded by a disc; however the origin of this rotation remains unclear. Mass transfer within close binaries provides the leading hypothesis, with previous detections of stripped companions to Be stars supporting this. Here, we exploit the exquisite astrometric precision of Gaia to carry out the largest to date comparative study into the binarity of matched samples of nearby B and Be stars from the Bright Star Catalogue. By utilizing new ‘proper motion anomaly’ values, derived from Gaia DR2 and DR3 astrometric data alongside previous values calculated using Hipparcos and Gaia data, and the Gaia-provided RUWE, we demonstrate that we can identify unresolved binaries down to separations of 0.02 arcsec. Using these measures, we find that the binary fractions of B and Be stars are similar between 0.04 and 10 arcsec, but the Be binary fraction is significantly lower than that of the B stars for separations below 0.04 arcsec. As the separation range of these ‘missing’ binaries is too large for mass transfer, and stripped companions are not retrieved by these measures, we suggest the companions migrate inwards via binary hardening within a triple system. This confirms statistically for the first time the hypothesis that binary interaction causes the Be phenomenon, with migration causing the dearth of Be binaries between 0.02 and 0.04 arcsec. Furthermore, we suggest that triplicity plays a vital role in this migration, and thus in the formation of Be stars as a whole