Unusually heavy catches of ribbon fish close to the shore at Visakhapatnam

Very heavy catches of ribbonfish were observed quite close to the shore at Visakhapatnam for a very short duration. Observations were made on this fishery and certain important biological aspects Ribbonfish do not generally come very close to the shore. As such they are vei7 rarely caught in the shore-seines. They are normally caught in boatseines operating 3-4 km away from the shore and in trawl nets. It is possible that the ribbon fish shoal after spawning hit the shore chasing their food consisting of Stolephorus sp, Leiognathus sp. Etc. Which might have been moving closer to the Shore to avoid the cold upwelled water

Metal Matrix Composites as Potential Armour Materials

To defeat a kinetic energy projectile the armour needs to be extremely hard on the surface, so as to blunt the projectile on initial impact. A ceramic material may be an ideal choice. However, to absorb and dissipate the complete kinetic energy of the projectile, the subsequent material has to be extremely tough with a very high work of fracture. It also needs to be a light weight material to keep the overall weight to a minimum possible value. A fibre reinforced polymer matrix composite can meet the requirement. The innermost laver needs to have a very high ductility so as to avoid any fracture and fragment formation which could be lethal. So it has to be a metallic material. Thus, the application requires a range of properties starting from that of a ceramic and ending with that of a metal. Metal matrix composites (MMCs) are essentially metals reinforced with ceramic reinforcements, which exhibit a combination of properties of both the constituents and could be tailored to suit the requirements. Discontinuously reinforced MMCs also have the added advantage of being amenable to conventional metal forming operations, which makes it easier to produce them in the required shapes. This paper would provide an introduction to MMCs and review the available literature on their evaluation for possible applications as armour materials.It would also present the results of the preliminary studies on the dynamic hardness measurements of discontinuously reinforced aluminium alloy composites which gives a good indication of their potential use as armour materials

Road traffic accidents attending casualty in a tertiary care hospital : a 03 year study from South Western India

Background: Road Traffic Accident (RTA) is any vehicular accident occurring on the roadway i.e. originating on, terminating on, or involving a vehicle partially on the roadway. Road traffic accidents are a human tragedy which has an immeasurable impact on the families affected. The WHO estimates that over 1.2 million people pass away every year on the world’s roads, and between 20 and 50 million fall victims to non-fatal injuries.  The incidence of RTA remains poorly measured in India.Methods: The present study is conducted at casualty department of a tertiary care hospital in South Western India among victims of road traffic accident. This cross sectional study was conducted to elucidate the role of various factors involved in road traffic accidents and to study demographic profile and injury pattern among RTA victims. All the reported RTA cases from 1st January 2016 to 31st December 2018 were included in the study.Results: A total of 875 cases of RTA were studied. There were 83.77%(n=733) male and 16.23%(n=142) female accident victims. Most of the patients were aged between 21 and 30 years. Monsoons witnessed 46.63%(n=408) cases. Most cases occurred between 6 and 12pm (54.4%, n=476). Commonest injury was a simple injury (72.91%, n=638), dangerous injuries (27.09% percent, n=237) and dead was (7.43%, n=65). The highest number of accidents took place in the month of June (19.09%, n=167) and on Sundays (22.17%). Among the motorized vehicles, two-wheeler drivers were more (76.91%, n=673) involved in accidents. In this study 17.60% (n=154) were under influence of alcohol while driving.Conclusions: This study shows there are multiple factors associated with road traffic accidents. Most of the factors responsible for RTA and its fatal consequences are preventable. India, as a signatory to the Brasilia declaration, intends to reduce road accidents and traffic fatalities by 50% by 2022. A comprehensive multipronged approach can mitigate most of them

DEVELOPMENT OF OSMOTICALLY CONTROLLED ORAL DRUG DELIVERY SYSTEM FOR NATEGLINIDE AN ANTI-DIABETIC DRUG

Objective: The purpose of the present study was to develop an oral push-pull osmotic drug delivery system for the drug Nateglinide which is a bio pharmaceutics classification system (BCS) class II drug. Methods: The tablets were prepared by the wet granulation method using ingredients microcrystalline cellulose (Adsorbent), potassium chloride (Osmotic agent), poly ethylene glycol (4000 and 6000) (Hydrophilic polymer, Plasticizer), starch (Disintegrant), and aerosil. The granules were compacted by double compression method and were coated with eudragit by dipping method. Different batches were prepared to study the effect of the various ingredients and their effect on the release of the drug from the system by varying the concentrations of the ingredients in each batch. Dissolution was assessed using USP dissolution apparatus 2 in phosphate buffer pH 6.8 for 12 h. Results: Certain key findings observed includes a decrease in micro crystalline cellulose content reduced the release of the drug due to the reduction of the hydrophilic content in the tablet which complements the uptake of water from the surroundings, and increase in the ethylene glycol leads to decrease in the release which resulted due to excess swelling and increase in the osmotic agent concentration lead to satisfactory release of the drug and followed zero-order release. Conclusion: To conclude, the push-pull osmotic tablet of Nateglinide was able to deliver the drug in a controlled pattern for a prolonged period of time. This type of formulation can be used in conditions like hyperglycemia where the patient compliance can improve by reducing the dosing frequency and the plasma drug levels can be maintained, the total drug load is also reduced so that the dose related side-effects are also reduced. Keywords: Controlled release, Push-pull osmotic pump, Nateglinid

The Diet, Physical Activity and Accommodation of Patients with Quiescent Pulmonary Tuberculosis in a Poor South Indian Community

A previous report from the Tuberculosis Chemotherapy Centre, Madras, has shown that, if standard chemotherapy is given for one year, the response of patients treated at home in very poor environmental circumstances is nearly as good as that of those treated in sanatorium under much more favourable conditions. This paper reports on a four-year follow-up of all the patients whose disease was bacteriologically quiescent at the end of the year’s treatment. During this period, all the patients were managed on a domiciliary basis : about a quarter of them received chemotherapy with isoniazid alone for two years, another quarter received the drug for one year and the rest received no specific chemotherapy. Despite adverse environmental factors (poor diet ; long hours of work often involving strenuous physical activity ; overcrowded living conditions ; and, for the sanatorium patients, the stresses of returning suddenly to the unfavourable home environment), the great majority of patients in both series maintained quiescent disease throughout the follow-up period. Furthermore, the few patients whose disease relapsed bacteriologically were at no special dietary disadvantage in comparison with those who maintained quiescent disease throughout, nor did they show any appreciable differences in occupation, physical activity or living accommodation. These findings, together with the earlier ones, indicate that, despite adverse environmental circumstances, standard chemotherapy for an adequate period of time is sufficient in the great majority of patients for the attainment of bacteriological quiescence and its maintenance thereafter

Magnetic anomalies of offshore Krishna-Godavari basin, eastern continental margin of India

The marine magnetic data acquired from offshore Krishna-Godavari (K-G) basin, eastern continental margin of India (ECMI), brought out a prominent NE-SW trending feature, which could be explained by a buried structural high formed by volcanic activity. The magnetic anomaly feature is also associated with a distinct negative gravity anomaly similar to the one associated with 85°E Ridge. The gravity low could be attributed to a flexure at the Moho boundary, which could in turn be filled with the volcanic material. Inversion of the magnetic and gravity anomalies was also carried out to establish the similarity of anomalies of the two geological features (structural high on the margin and the 85°E Ridge) and their interpretations. In both cases, the magnetic anomalies were caused dominantly by the magnetization contrast between the volcanic material and the surrounding oceanic crust, whereas the low gravity anomalies are by the flexures of the order of 3-4 km at Moho boundary beneath them. The analysis suggests that both structural high present in offshore Krishna-Godavari basin and the 85°E Ridge have been emplaced on relatively older oceanic crust by a common volcanic process, but at discrete times, and that several of the gravity lows in the Bay of Bengal can be attributed to flexures on the Moho, each created due to the load of volcanic material

A novel system to obtain addresses of out-patients-assessent in routine clinic practice in Madras

A novel method of obtaining accurate home addresses from out-patients was introduced as a routine procedure in 6 chest clinics of Madras City, following highly satisfactory results under study conditions. In this method, the patient is given a card (the address card), and asked to get his exact address entered on it by any knowledgeable person of his choice such as a landlord or neighbour. An assessment of the system was undertaken after it had been in operation for about 8 months. A complete and legible address was available for 82 % of 3956 patients, the range in the 6 clinics being 74 % to 91 %. The main causes for failure were : not giving address card to patient (7 %), patient not reattending the clinic (6 %), and patient reattending but not returning the address card (3%). Corrective measures have now been introduced, and a re-assessment will be undertaken in due course

A novel system to obtain addresses of out-patients-assessment in routine clinic practice in Madras

A novel method of obtaining accurate home addresses from out-patients was introduced as a routine procedure in 6 chest clinics of Madras City, following highly satisfactory results under study conditions. In this method, the patient is given a card (the Address card), and asked to get his exact address entered on it by any knowledgeable person of his choice such as the landlord or a neighbour. An assessment of the system was undertaken after it had been in operation for about 8 months. A complete and legible address was available for 82 % of 3956 patients, the range in the 6 clinics being 74% to 91%. The main causes for failure were: not giving Address card to patient (7 %), patient not reattending the clinic (6%), and patient reattending but not returning the Address card (3 %). Corrective measures have now been introduced, and a re-assessment will be undertaken in due course

Self-similar shear-thickening behavior in CTAB/NaSal surfactant solutions

The effect of salt concentration Cs on the critical shear rate required for the onset of shear thickening and apparent relaxation time of the shear-thickened phase, has been investigated systematically for dilute CTAB/NaSal solutions. Experimental data suggest a self-similar behavior of the critical shear rate and relaxation time as functions of Cs. Specifically, the former ~ Cs^(-6) whereas the latter ~ Cs^(6) such that an effective Weissenberg number for the onset of the shear thickened phase is only weakly dependent on Cs. A procedure has been developed to collapse the apparent shear viscosity versus shear rate data obtained for various values of Cs into a single master curve. The effect of Cs on the elastic modulus and mesh size of the shear-induced gel phase for different surfactant concentrations is discussed. Experiments performed using different flow cells (Couette and cone-and-plate) show that the critical shear rate, relaxation time and the maximum viscosity attained are geometry-independent. The elastic modulus of the gel phase inferred indirectly by employing simplified hydrodynamic instability analysis of a sheared gel-fluid interface is in qualitative agreement with that predicted for an entangled phase of living polymers. A qualitative mechanism that combines the effect of Cs on average micelle length and Debye parameter with shear-induced configurational changes of rod-like micelles is proposed to rationalize the self-similarity of SIS formation.Comment: 27 pages, 17 figure

A double-blind study to determine the maximum tolerated dose of ethionamide, when administered twice-weekly to patients with pulmonary tuberculosis

ATI earlier report from this Centre (Tuber-culosis Chemotherapy Centre, Madras, 1964) showed that a fully supervised twice-weekly regimen of streptomycin plus high-dosage isoniazid was highly effective in the treatment of patients with newly-diagnosed bacteriologi-cally confirmed pulmonary tuberculosis. How-ever, this regimen involves intramuscular injections of streptomycin and may not always be easy to organize, especially in rural areas and in developing countries with limited resources. For this reason, it was decided to investigate the possibility of replacing strepto-mycin in the twice-weekly regimen by two oral drugs, namely ethionamide and PAS. Ethiona-mide was chosen since, apart from isoniazid and streptomycin, it was the most potent drug available at the time, and PAS was included with a view to enhance the efficacy of the regimen. Finally, it was decided that the patients should be given an intensive phase of daily treatment with streptomycin, PAS and isoniazid for two weeks. Experiments in the guinea-pig had shown that the size of the individual dose of a drug needed to be increased as the interval between successive doses was increased (Dickinson & Mitchison, 1966). As PAS is bulky and the dosage of isoniazid in the twice-weekly regimen was already high, namely 15 mg./kg. body-weight, it was decided to explore the possibility of increasing the dosage of ethionamide to a level higher than that usually employed (0.5— 1.0 g.) in daily regimens. An investigation was therefore undertaken to determine the maximum tolerated dose of ethionamide. when administered twice-weekly together with isonia-zid plus PAS. Since the assessment of ethio-namide intolerance is largely subjective, the study was conducted ‘double-blind’ with respect to the dosage of ethionamide