Effects of training on the extent of experimental myocardial infarction in aging rats

The effects of exercise on the severity of isoproterenol [7683-​59-​2]​-​induced myocardial infarction were studied in female albino rats of 20, 40, 60, and 80 wk of age. The rats were trained to swim for a specific duration and for a particular period. The occurrence of infarcts were confirmed by histol. methods. Elevations in the serum glutamate-​oxaloacetic transaminase (GOT) [9000-​97-​9] and glutamate-​pyruvate transaminase (GPT) [9000-​86-​6] were max. in the sedentary-​isoproterenols and min. in the exercise controls. These changes in the serum transaminases were assocd. with corresponding depletions in the cardiac GOT and GPT. However, age interfered with the responses exhibited by the young and old rats

Enabling Public Verifiability and Data Dynamics for Storage Security in Cloud Computing

Distributed computing has been emerged as a key element in engineering of IT Enterprise. In distributed computing environment it is mandatory to place necessary databases and their corresponding application programming in the unified vast server farms, where the information and administrations may not be completely reliable. This involves numerous new security challenges, which are unpredictable. This paper focuses on guaranteeing the reliability of information stockpiling in Cloud Computing environment. The third party administrator in collaboration with the customer ensures whether his information dispensed in the proper place in the cloud, which can be critical in accomplishing economies of scale for Cloud Computing. The help for information progression by means of the broadest types of information operation, for example, piece adjustment, inclusion and erasure is additionally a huge advance toward common sense, since administrations in Cloud Computing are not restricted to file or reinforcement information as it were. We initially recognize the challenges and potential security issues of direct expansions with completely powerful information refreshes from earlier works and after that demonstrate to develop an exquisite confirmation conspire for the consistent mix of these two notable highlights in our convention plan. Specifically, to accomplish proficient information progression, we enhance the current evidence of capacity models by controlling the exemplary Merkle Hash Tree development for square label confirmation

An 18 mer sequence in a rat 1.3 kbp EcoRI repeat detects genetic polymorphism in humans

DNA fingerprinting involves the typing of an individual's DNA content to produce somatically stable,individual-specific DNA fingerprints. This technique often uses hypervariable minisatellite (HVMS) sequences as the fingerprinting probe and has found extensive use in several disciplines. Recently, we sequenced a 1.3 kbp EcoRI repetitive DNA fragment, shown to harbour the meiotic DNA repair site(s) of rat pachytene spermatocytes. This 1.3 kbp clone contained four sequences sharing high homology to the various HVMS sequences reported in the literature. Here we show that one of the sequences can indeed detect polymorphism in human individuals and can be used for DNA fingerprinting

Activity of alanine aminotransferase in serum and ventricular tissue of rats after exercise as a function of age

The activity of alanine aminotransferase (I) in both blood serum and heart ventricle was higher in 180-​day-​old rats than in 60-​day-​old rats. Swimming for 30 min and 60 min significantly increased blood serum I activity in both 60- and 180-​day-​old rats. The activity of I in the heart ventricle, however, decreased during both exercise periods in both age groups

Profile of cutaneous adverse drug reactions of carbamazepine

Background: Carbamazepine, a commonly used antiepileptic drug is known to produce adverse effects including dangerous reactions like cutaneous hypersensitivity reactions such as drug induced hypersensitivity syndrome (DHS), Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). The FDA released a warning that serious and potentially fatal skin reactions may occur after carbamazepine in patients positive for the HLA-B*1502 allele which occurs almost exclusively in patients with ancestry across broad areas of Asia, including South Asian Indians. This study profiles the cutaneous adverse drug reactions reported in this institute over a period of 3 years.Methods: This retrospective study was conducted at Tirunelveli Medical College Hospital by analysing patient case records based on adverse drug reactions reported between August 2014 and July 2017 in the adverse drug reaction monitoring centre. The age, gender, diagnosis, type of cutaneous ADR, duration of treatment, seriousness of reaction and outcome were recorded and analysed.Results: Among the total 25 reactions 36% were benign and 64% were severe reactions. According to Pharmaco vigilance Program of India 80% of the reactions were serious and 20% non serious. The commonest benign skin reaction was maculopapular eruption. SJS and TEN were the two very serious reactions which affected 8 patients totally. Exfoliative dermatitis was reported in 7 patients and Drug Hypersensitivity Syndrome (DHS) in one patient.Conclusions: Severe cutaneous reactions occur after carbamazepine and prevention of ADR requires prediction of predisposition which requires special studies of HLA or genomic assessment. These are the issues of interest for future research

The Role of Serum Interleukin-6 Levels in Prognosticating Postoperative Complications After Cytoreductive Surgery for Ovarian Cancers: A Prospective Observational Study

Background: Interleukin-6 (IL-6), a pro-inflammatory cytokine, has been associated with adverse prognosis in ovarian cancer. Cytoreductive surgery for ovarian cancer has a higher risk of postoperative surgical complications (POCs). We aimed to find out if serum IL-6 is elevated preoperatively in patients undergoing cytoreductive surgery for ovarian cancer and if it can predict POCs. We also compared its trend with serum C-reactive protein (CRP) in the early postoperative period. Materials and Methods: Fifty-one patients between 18–75 years, posted for elective ovarian cytoreductive surgery at a tertiary cancer hospital were included after taking informed consent. Serum IL-6 and CRP were done the day before surgery and repeated 24 and 72 hours post-surgery. All parameters that affect POCs were captured. POCs were graded using the Clavein Dindo classification. We recorded the length of the intensive care unit (ICU), hospital stay, and 30-day mortality. Appropriate statistical tests were used and p value <0.05 was considered significant. Results: Out of 51 enrolled patients, 46 were included for data analysis after exclusions. The mean age of patients in this study was 49.76 +/- 12.42 years with a mean surgical duration of 302.39 +/- 127.04 minutes and mean blood loss of 332.6 +/- 274.71 mL. The incidence of POCs in our study was 21.7% (10/46 patients). Preoperative IL-6 was raised and was able to predict POCs with 70% sensitivity and 86% specificity at a cutoff value of 23.56 pg./mL (R2 = 0.71; AUC = 0.79). In patients who developed POCs, IL-6 values (1196.7+/-1461.4 pg./mL) peaked at 24 hours whereas CRP values (360 +/- 430.1 mg/L) peaked at 72 hours; thus, allowing early prognostication with IL-6. The cut-off value of serum IL-6 at 24 hours to predict POCs is 480 pg./mL (R2 = 0.50; AUC = 0.79) with 80% sensitivity and 89% specificity. Two patients died - on postoperative days 5 and 28 respectively. Conclusion: Preoperative IL-6 is raised in patients with ovarian cancer posted for cytoreductive surgery. A cut-off value of 23.56 pg./mL preoperatively and 480 pg./mL at 24 hours after surgery could predict postoperative surgical complications

Study on Efficacy of Expired and Active Forms of Various Antibiotics on Saccharomyces cerevisiae

Antibiotics are among the most frequently prescribed medications in modern medicines. The cell protection strategies in the organisms, development of resistance in previously susceptible microbes, the inevitable progression of microbes exposed to antibiotics to develop resistance, were the nesisities that ensures the need for continual cycles of discovery and development of new antibiotics. A large variety of antibiotics are available in the drug market today, several others being added regularly in combat with various pathogens that cause disease in humans as well as in animals. Our present study focused to investigate the change in efficacy of commonly used antibiotics such as amoxicillin, ampicillin, sparfloxacin, cefixime. We have collected antibiotics with before and after their expiry dates. A simple eukaryotic model organism Saccharomyces cerevisiae is used to study the comparative understanding of this microbe with these different antibiotics. In our investigation we found that response of Sacchromyces cerevisiae towards different antibiotics varied in its intricacies. Fresh forms of antibiotics have significantly inhibiting the growth of Saccharomyces cerevisiae as compared to expired forms. The observations revealed that expired forms of antibiotics loose their efficacy drastically

Esophageal Small Cell Carcinoma with Synchronous Renal Cell Carcinoma: A Case Report with Review of the Literature

Synchronous malignancies with an esophageal malignancy are not uncommon. However synchronous esophageal and renal cell carcinoma (RCC) is rare with only 11 cases reported in the world literature, the esophageal malignancies being adenocarcinomas or squamous cell carcinomas. Here, we report the first case of synchronous small cell carcinoma (SCC) of the esophagus with a RCC. SCC of the esophagus is an aggressive malignancy with poor prognosis constituting 0.8–2.4% of all esophageal malignancies, currently treated with induction chemotherapy followed by chemoradiotherapy. Our patient underwent chemoradiotherapy for the SCC of the esophagus followed by radical nephrectomy for the RCC. He developed metastatic disease and died 8 months after diagnosis. Larger case series are required to develop a treatment algorithm for such a rare presentation. The key points of this report are: (1) Synchronous RCC with a primary esophageal carcinoma is a rare presentation. (2) This is the first described case report of a SCC of the esophagus with a synchronous RCC. (3) Overall prognosis in a synchronous presentation is determined by the primary esophageal malignancy. (4) Esophageal carcinomas with synchronous malignancies have a poorer prognosis compared to isolated esophageal carcinoma