Three-dimensional and Two-dimensional Modelling of Springback in the Single-pass Conventional Metal Spinning of Cones

Parts for industrial and domestic use have been formed by means of the metal spinning process as far back as the ancient Egyptians. Research into the field was initially concentrated on experimental and theoretical studies. The development of numerical methods alongside the increasing capabilities of modern computing brought about numerical investigations into the process. This thesis presents a three-dimensional numerical model developed using the finite element method. In addition, a formability parameter is proposed and a formability surface linking the round off radius, rotational speed and half cone angle of the mandrel is presented. This thesis also presents the first numerical parametric study into springback using a three-dimensional finite element model

Encouraging use of subordination in children’s narratives: a classroom-based priming study

This study investigated the long-term effect of classroom-based input manipulation on children’s use of subordination in a story re-telling task; it also explored the role of receptive vocabulary skills and expressive grammatical abilities in predicting the likelihood of priming. During a two-week priming phase, 47 monolingual English-speaking five- year-olds heard 10 stories, one a day, that either contained a high proportion of subordinate clauses (subordination condition) or a high proportion of coordi- nate clauses (coordination condition). Post-intervention, there was a significant group difference in likelihood of subordinate use which persisted ten weeks after the priming. Neither expressive grammatical nor receptive vocabulary skills were positively correlated with the likelihood of subordinate use. These findings show that input manipulation can have a facilitative effect on the use of complex syntax over several weeks in a realistic communicative task

Ryanodine receptors, a family of intracellular calcium ion channels, are expressed throughout early vertebrate development

<p>Abstract</p> <p>Background</p> <p>Calcium signals ([Ca²⁺]_i) direct many aspects of embryo development but their regulation is not well characterised. Ryanodine receptors (RyRs) are a family of intracellular Ca²⁺release channels that control the flux of Ca²⁺from internal stores into the cytosol. RyRs are primarily known for their role in excitation-contraction coupling in adult striated muscle and <it>ryr </it>gene mutations are implicated in several human diseases. Current evidence suggests that RyRs do not have a major role to play prior to organogenesis but regulate tissue differentiation.</p> <p>Findings</p> <p>The sequences of the five zebrafish <it>ryr </it>genes were confirmed, their evolutionary relationship established and the primary sequences compared to other vertebrates, including humans. RyRs are differentially expressed in slow (<it>ryr1a</it>), fast (<it>ryr3</it>) and both types (<it>ryr1b</it>) of developing skeletal muscle. There are two <it>ryr2 </it>genes (<it>ryr2a </it>and <it>ryr2b</it>) which are expressed exclusively in developing CNS and cardiac tissue, respectively. In addition, <it>ryr3 </it>and <it>ryr2a </it>mRNA is detectable in the initial stages of development, prior to embryonic axis formation.</p> <p>Conclusions</p> <p>Our work reveals that zebrafish <it>ryr </it>genes are differentially expressed throughout the developing embryo from cleavage onwards. The data suggests that RyR-regulated Ca²⁺signals are associated with several aspects of embryonic development, from organogenesis through to the differentiation of the musculoskeletal, cardiovascular and nervous system. These studies will facilitate further work to explore the developmental function of RyRs in each of these tissue types.</p

Is simulation the ultimate integrated physiological experience?

An understanding of physiology is a core part of any medical training and key for the development of critical thinking and clinical reasoning skills. Research has shown that the construction and application of physiological knowledge by medical students changes as their expertise increases, so learning activities within curricula should be designed to reflect this (Bandiera et al., 2018)

Building back better: Purpose-driven business schools

Despite their many achievements, business schools are criticised for prioritising the achievement of outcomes, such as revenue and rankings, over the pursuit of their purpose. Acknowledging the inherent variation among the world's many business schools, most were created with some idea of enhancing the public good by nurturing the management profession and conducting related scholarship. As business schools display inertia while corporations change to pursue purpose, a rift is emerging between the interests of participants in the business school industry. The P-School category comprises a diverse combination of seven business schools based at the universities of: Birmingham, Cardiff, Glasgow Caledonian, University of Arts London, Manchester, Queen Mary University of London, and Queen's Belfast

Weakening the glass ceiling: does organizational growth reduce gender segregation in the upper tiers of Danish local government?

The theory of representative bureaucracy highlights gender segregation in the public sector and its detrimental implications for public policy outcomes. Focusing attention on organisational responses to this protracted problem, we supply evidence on whether organizational growth provides potential for change in the upper echelons of the public sector. An evaluation of the relationship between new hires and gender representation within the management tiers of Danish local government reveals an association between the recruitment of additional employees and improved gender integration. This is particularly pronounced for public organizations that employ fewer women. Implications for theory and practice are discussed