Membrane, Four-Brane and Dual Coordinates in the M(atrix) Theory Compactified on Tori

In the M(atrix) theory by making the expansions of the matrices around the membrane and four-brane solutions we derive the three- and five-dimensional gauge theories on the dual tori. The explicit forms of solutions yield the dual coordinates and each expansion is related to a toroidal compactification of the M(atrix) theory. From the derived Lorentz and gauge invariant actions the gauge coupling constants are shown to be characterized by the volume of the dual tori.Comment: 9 pages, latex, no figure

Classical Equations for Quantum Systems

The origin of the phenomenological deterministic laws that approximately govern the quasiclassical domain of familiar experience is considered in the context of the quantum mechanics of closed systems such as the universe as a whole. We investigate the requirements for coarse grainings to yield decoherent sets of histories that are quasiclassical, i.e. such that the individual histories obey, with high probability, effective classical equations of motion interrupted continually by small fluctuations and occasionally by large ones. We discuss these requirements generally but study them specifically for coarse grainings of the type that follows a distinguished subset of a complete set of variables while ignoring the rest. More coarse graining is needed to achieve decoherence than would be suggested by naive arguments based on the uncertainty principle. Even coarser graining is required in the distinguished variables for them to have the necessary inertia to approach classical predictability in the presence of the noise consisting of the fluctuations that typical mechanisms of decoherence produce. We describe the derivation of phenomenological equations of motion explicitly for a particular class of models. Probabilities of the correlations in time that define equations of motion are explicitly considered. Fully non-linear cases are studied. Methods are exhibited for finding the form of the phenomenological equations of motion even when these are only distantly related to those of the fundamental action. The demonstration of the connection between quantum-mechanical causality and causalty in classical phenomenological equations of motion is generalized. The connections among decoherence, noise, dissipation, and the amount of coarse graining necessary to achieve classical predictability are investigated quantitatively.Comment: 100pages, 1 figur

Gauge Theory of the String Geodesic Field

A relativistic string is usually represented by the Nambu-Goto action in terms of the extremal area of a 2-dimensional timelike submanifold of Minkowski space. Alternatively, a family of classical solutions of the string equation of motion can be globally described in terms of the associated geodesic field. In this paper we propose a new gauge theory for the geodesic field of closed and open strings. Our approach solves the technical and conceptual problems affecting previous attempts to describe strings in terms of local field variables. The connection between the geodesic field, the string current and the Kalb-Ramond gauge potential is discussed and clarified. A non-abelian generalization and the generally covariant form of the model are also discussed.Comment: 38 pages, PHYZZX, UTS-DFT-92-2

Solvable model of strings in a time-dependent plane-wave background

We investigate a string model defined by a special plane-wave metric ds^2 = 2dudv - l(u) x^2 du^2 + dx^2 with l(u) = k/u^2 and k=const > 0. This metric is a Penrose limit of some cosmological, Dp-brane and fundamental string backgrounds. Remarkably, in Rosen coordinates the metric has a ``null cosmology'' interpretation with flat spatial sections and scale factor which is a power of the light-cone time u. We show that: (i) This spacetime is a Lorentzian homogeneous space. In particular, like Minkowski space, it admits a boost isometry in u,v. (ii) It is an exact solution of string theory when supplemented by a u-dependent dilaton such that its exponent (i.e. effective string coupling) goes to zero at u=infinity and at the singularity u=0, reducing back-reaction effects. (iii) The classical string equations in this background become linear in the light-cone gauge and can be solved explicitly in terms of Bessel's functions; thus the string model can be directly quantized. This allows one to address the issue of singularity at the string-theory level. We examine the propagation of first-quantized point-particle and string modes in this time-dependent background. Using certain analytic continuation prescription we argue that string propagation through the singularity can be smooth.Comment: 58 pages, latex. v2: several references to related previous work adde

Identification of the HSPB4/TLR2/NF-κB axis in macrophage as a therapeutic target for sterile inflammation of the cornea

Sterile inflammation underlies many diseases of the cornea including serious chemical burns and the common dry eye syndrome. In search for therapeutic targets for corneal inflammation, we defined the kinetics of neutrophil infiltration in a model of sterile injury to the cornea and identified molecular and cellular mechanisms triggering inflammatory responses. Neutrophil infiltration occurred in two phases: a small initial phase (Phase I) that began within 15 min after injury, and a larger second phase (Phase II) that peaked at 24–48 h. Temporal analysis suggested that the neuropeptide secretoneurin initiated Phase I without involvement of resident macrophages. Phase II was initiated by the small heat shock protein HSPB4 that was released from injured keratocytes and that activated resident macrophages via the TLR2/NF-κB pathway. The Phase II inflammation was responsible for vision-threatening opacity and was markedly suppressed by different means of inhibition of the HSPB4/TLR2/NF-κB axis: in mice lacking HSPB4 or TLR2, by antibodies to HSPB4 or by TNF-α stimulated gene/protein 6 that CD44-dependently inhibits the TLR2/NF-κB pathway. Therefore, our data identified the HSPB4/TLR2/NF-κB axis in macrophages as an effective target for therapy of corneal inflammation

Semiclassical Strings, Dipole Deformations of N=1 SYM and Decoupling of KK Modes

In this paper we investigate the recently found $\gamma$-deformed Maldacena-Nunez background by studying the behavior of different semiclassical string configurations. This background is conjectured to be dual to dipole deformations of $\N=1$ SYM. We compare our results to those in the pure Maldacena-Nunez background and show that the energies of our string configurations are higher than in the undeformed background. Thinking in the lines of (hep-th/0505100) we argue that this is an evidence for better decoupling of the Kaluza-Klein modes from the pure SYM theory excitations. Moreover we are able to find a limit of the background in which the string energy is independent of $\gamma$, these strings are interpreted as corresponding to pure gauge theory effects.Comment: 31 pages, references added, new solutions in Section 7 presented, an appendix added, to appear in JHE

D1-brane in beta-Deformed Background

We study various configurations of rotating and wound D1-brane in AdS_5\times S^5 background and in its beta deformed version. We find giant magnon and spike solutions on the world-volume of D1-brane in AdS_5\times S^5 background. We also analyse the equations of motion of D1-brane in beta-deformed background. We show that in the limit of large electric flux on world-volume of D1-brane they reduce to the equations that describe collection of large number of fundamental strings. We also construct rotating and wound D1-brane solution that has two equal spins on S^5_\gamma.Comment: 26 pages, appendices and a reference added, to appear in JHE

Green-Schwarz Strings in TsT-transformed backgrounds

We consider classical strings propagating in a background generated by a sequence of TsT transformations. We describe a general procedure to derive the Green-Schwarz action for strings. We show that the U(1) isometry variables of the TsT-transformed background are related to the isometry variables of the initial background in a universal way independent of the details of the background. This allows us to prove that strings in the TsT-transformed background are described by the Green-Schwarz action for strings in the initial background subject to twisted boundary conditions. Our construction implies that a TsT transformation preserves integrability properties of the string sigma model. We discuss in detail type IIB strings propagating in the \g_i-deformed AdS_5 x S^5 space-time, find the twisted boundary conditions for bosons and fermions, and use them to write down an explicit expression for the monodromy matrix. We also discuss string zero modes whose dynamics is governed by a fermionicgeneralization of the integrable Neumann model.Comment: 33 pages, latex, v2: typos correcte

Solulin reduces infarct volume and regulates gene-expression in transient middle cerebral artery occlusion in rats

<p>Abstract</p> <p>Background</p> <p>Thrombolysis after acute ischemic stroke has only proven to be beneficial in a subset of patients. The soluble recombinant analogue of human thrombomodulin, Solulin, was studied in an <it>in vivo </it>rat model of acute ischemic stroke.</p> <p>Methods</p> <p>Male SD rats were subjected to 2 hrs of transient middle cerebral artery occlusion (tMCAO). Rats treated with Solulin intravenously shortly before reperfusion were compared to rats receiving normal saline i.v. with respect to infarct volumes, neurological deficits and mortality. Gene expression of IL-6, IL-1β, TNF-α, MMP-9, CD11B and GFAP were semiquantitatively analyzed by rtPCR of the penumbra.</p> <p>Results</p> <p>24 hrs after reperfusion, rats were neurologically tested, euthanized and infarct volumes determined. Solulin significantly reduced mean total (p = 0.001), cortical (p = 0.002), and basal ganglia (p = 0.036) infarct volumes. Hippocampal infarct volumes (p = 0.191) were not significantly affected. Solulin significantly downregulated the expression of IL-1β (79%; p < 0.001), TNF-α (59%; p = 0.001), IL-6 (47%; p = 0.04), and CD11B (49%; p = 0.001) in the infarcted cortex compared to controls.</p> <p>Conclusions</p> <p>Solulin reduced mean total, cortical and basal ganglia infarct volumes and regulated a subset of cytokines and proteases after tMCAO suggesting the potency of this compound for therapeutic interventions.</p