9 research outputs found
B7-H5 costimulates human T cells via CD28H
- Author
- AM Fahrer
- AN Vallejo
- BM Carreno
- D Hamann
- D Hamann
- DJ Lenschow
- DL Mager
- DL Woodland
- EM Aandahl
- F Sallusto
- F Sallusto
- F Vincenti
- FA Harding
- FS Hodi
- H Dong
- H Dong
- JM Brenchley
- JM Kremer
- JM Taube
- JR Brahmer
- JR Brahmer
- KV Prasad
- L Chen
- LH Boise
- LM Wakim
- M Croft
- MA King
- NP Weng
- PS Linsley
- RA Clark
- RA Wilcox
- RB Effros
- RH Schwartz
- RJ Greenwald
- RV Parry
- S Yao
- SL Topalian
- T Pentcheva-Hoang
- TH Watts
- V Ling
- Y Zhu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2013
- Field of study
The B7/CD28 family has profound modulatory effects in immune responses and constitutes an important target for the development of novel therapeutic drugs against human diseases. Here we describe a new CD28 homologue (CD28H) that has unique functions in the regulation of the human immune response and is absent in mice. CD28H is constitutively expressed on all naive T cells. Repetitive antigenic exposure, however, induces a complete loss of CD28H on many T cells, and CD28H negative T cells have a phenotype of terminal differentiation and senescence. After extensive screening in a receptor array, a B7-like molecule, B7 homologue 5 (B7-H5), was identified as a specific ligand for CD28H. B7-H5 is constitutively found in macrophages and could be induced on dendritic cells. The B7-H5/CD28H interaction selectively costimulates human T-cell growth and cytokine production via an AKT-dependent signalling cascade. Our study identifies a novel costimulatory pathway regulating human T-cell responses.National Institutes of Health (U.S.) (Grant CA98721)National Institutes of Health (U.S.) (Grant CA113341)National Institutes of Health (U.S.) (Grant AI72592
Morphological and cellular aspects of tail and limb regeneration in lizards: a model system with implications for tissue regeneration in mammals
- Author
- A d’A Bellairs
- A Hughes
- A Misuri
- AJ Schmidt
- AL Mesher
- AM Bauer
- AM Boring
- AR Clause
- BM Carlson
- BM Carlson
- C Lopez-Garcia
- CB Daniels
- CJ Hardy
- CM Mather
- CP White
- CR Irwin
- D Quattrini
- D Quattrini
- D Quattrini
- D Quattrini
- DA Smith
- DB Wake
- DK Magon
- DK Magon
- DK Magon
- DW VanBekkum
- E Guyenot
- E Guyenot
- E Marcucci
- E Marcucci
- E Marcucci
- E Pannese
- EH Colbert
- EN Arnold
- F Galis
- F Volante
- G Kuchling
- G Minelli
- HC Liu
- HS Fitch
- I Werber
- IW Whimster
- J Sabrazes
- J Zika
- JD Congdon
- JE Turner
- JE Turner
- JJ Jamison
- JJ Pritchard
- JJ Schall
- JP Brookes
- JP Dufaure
- K Desai
- L Alibardi
- L Alibardi
- L Alibardi
- L Alibardi
- L Alibardi
- L Alibardi
- L Alibardi
- L Alibardi
- L Alibardi
- L Alibardi
- L Alibardi
- L Alibardi
- L Alibardi
- L Alibardi
- L Alibardi
- L Alibardi
- L Alibardi
- L Alibardi
- L Alibardi
- L Alibardi
- L Alibardi
- L Calori
- L Zannone
- LA Moffat
- LD Beazley
- LJ Vitt
- LW Barber
- M Egar
- M Han
- M Harty
- M Marotta
- M Singer
- M Singer
- MD Purvis
- MT Duffy
- MWJ Ferguson
- N Radhakrishnan
- OJ Reichman
- P Brazaitis
- P Fraisse
- P Furieri
- P Furieri
- P Grande Del
- P Licht
- P Martin
- PA Tsonis
- PF Maderson
- PFA Maderson
- PFA Maderson
- PFA Maderson
- PG Cox
- PG Cox
- PM Brunetti
- RA Tassava
- RJ Goss
- RJ Goss
- RP Kamrin
- RV Kinariwala
- RV Shah
- RV Shah
- RV Shah
- RV Shah
- RV Shah
- S Geuna
- S Gianpaoli
- SA Alvarado
- SA Baranowitz
- SA Dunlop
- SA Mufti
- SA Mufti
- SA Mufty
- SB Simpson
- SB Simpson
- SB Simpson
- SB Simpson Jr
- SB Simpson Jr
- SB Simpson Jr
- SE Evans
- SE Evans
- SF Fox
- SJ Odelberg
- SR Scadding
- SV Bryant
- SV Bryant
- SV Bryant
- SV Bryant
- T Terni
- T Terni
- T Terni
- TC Byerly
- TL Maginnis
- TV Chakko
- VP Kudokotsev
- WG Hellmich
- WNF Woodland
- YL Werner
- YL Werner
- YL Werner
- Z Charvat
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2010
- Field of study
The present Review summarizes studies on the process of tissue regeneration of lizards, intended as amodel to understand the process of regeneration in amniote
A comparative life cycle assessment of commercially available household silver-enabled polyester textiles
- Author
- A Arild
- A Bankar
- A Gitipour
- A Hicks
- A Hicks
- A Hicks
- A Linden
- A Ronteltap
- Andrea L. Hicks
- B Kim
- C Hendren
- C Impellitteri
- C Lorenz
- C Murphy
- D Meyer
- E Lombi
- E Nieminen
- E Saouter
- F Rollin
- G Hustvedt
- H Gibbs
- H Klasen
- H Klasen
- H Lee
- H Lee
- H Ratte
- J Alexander
- J Hedberg
- J Jonker
- J Liu
- J Molling
- J Mylan
- J Tomlinson
- K Abeliotis
- K Gram-Hanssen
- K Laitala
- K Naddafi
- K Thakkar
- L Geranio
- L Pourzahedi
- L Pourzahedi
- L Reisch
- M El-Rafie
- M Siegrist
- M Siegrist
- N Goetz von
- N Gupta
- N Mahida
- N Staggers
- N Walter
- P Quaresma
- P Raveendran
- R Arvidsson
- R Huang
- R Kaegi
- R Ma
- R McQueen
- R Rankine
- R Reed
- R Stamminger
- R Woodland
- R Yawson
- RV Burri
- S Currall
- S Iravani
- S Marette
- S Smiley
- T Benn
- T Jack
- T Tolaymat
- T Walser
- Thomas L. Theis
- U Samuel
- V Sharma
- W Hill
- W Rutala
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Respiratory disease and the oesophagus: reflux, reflexes and microaspiration
- Author
- A Babaei
- A Banaszkiewicz
- A Bogte
- A Ducolone
- A Kelsall
- A Kelsall
- A Lee
- A Pauwels
- A Pauwels
- A Pauwels
- A Pauwels
- A Trioathi
- AA Gadel
- AB Chang
- AC Araujo
- AE Vertigan
- AF DiMarco
- AH Morice
- AJ Eherer
- AJ Ing
- AL Lee
- Augustine S. Lee
- B Avidan
- B Cavell
- B Lazarus
- B Salvioli
- BF Kessing
- BL Weusten
- BM Button
- BM Liang
- BS Becker
- C Almansa
- C Bodet-Milin
- C Casanova
- C Timms
- CA Ottenheijm
- CD Bandeira
- CE Kilduff
- CG Irvin
- CH Wong
- CL Mendelson
- CS Davis
- D Sifrim
- D Sifrim
- D Ummarino
- DA Mendell
- DN Wu
- DN Wu
- DO Francis
- DW Perng
- E Dimango
- E Savarino
- F D'Ovidio
- F Gao
- F Halter
- F Zerbib
- F Zerbib
- G Raghu
- GJ Wiener
- Huda Badri
- I Noth
- J Dent
- J Gea
- J Kim
- J Knight
- J Musser
- JA Kastelik
- JA Kastelik
- JA Smith
- JA Smith
- Jaclyn A. Smith
- JE Pandolfino
- JE Richter
- JE Richter
- JG Mastronarde
- JJ Leggett
- JK Bohman
- JS Bajaj
- JS Lee
- K Blondeau
- K Blondeau
- K Blondeau
- K Blondeau
- K Dua
- KD Gerson
- Kenneth R. DeVault
- KM Wheeler Hegland
- L Cvejic
- L Reid
- Lesley A. Houghton
- LH Ren
- LI Andersen
- LN Kelchner
- M Amaris
- M Grabowski
- M Hongo
- M Kreuter
- M Montes de Oca
- M Ribolsi
- M Sarkar
- M Setzen
- MA Jackson
- MA Nobre e Souza
- MA van Herwaarden
- MD Crowell
- MD Howell
- ME Allaix
- MF Vela
- MG Patti
- MN Schoeman
- MP Sweet
- MR Littner
- MR Stein
- N de Bortoli
- N Javorkova
- N Johannesson
- N Patterson
- NA Clayton
- NA Clayton
- NE Schindlbeck
- NJ Trudgill
- NL Kamble
- NM Ryan
- O Borrelli
- O Gajic
- O Kawamura
- OL Gastal
- P Herve
- P McNally
- P Woodland
- P Woodland
- PF Schnatz
- PG Gibson
- PJ Kahrilas
- R Abdulqawi
- R Breumelhof
- R Carvalho de Miranda Chaves
- R Chaiteerakij
- R Farre
- R Farre
- R Frankhuisen
- R Penagini
- R Shaker
- R Shaker
- R Trinick
- R Vardar
- RA Cassiani
- RC Branski
- RC Scheffer
- RG Heine
- RH Holloway
- RK Mittal
- RK Mittal
- RK Mittal
- RK Mittal
- RK Mittal
- RR Kempainen
- RS Irwin
- RT Kavitt
- RV Soares
- RW Tobin
- S Ayazi
- S Campo
- S Decalmer
- S Decalmer
- S Emerenziani
- S Kunsch
- S Mintz
- S Parikh
- SC Kadakia
- SI Rennard
- SJ Herzig
- SJ Sontag
- SK Field
- SL Gray
- SM Harding
- SY Phua
- SY Phua
- T Ekstrom
- T Hoppo
- TG Bautista
- TL Petty
- TM Ours
- TO Kiljander
- TO Kiljander
- TO Kiljander
- TO Kiljander
- W Gomm
- WA Amarasiri
- WC Orr
- WE Berquist
- WG Paterson
- Y Komatsu
- YM Fouad
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 06/07/2016
- Field of study
Crystal chemistry of amphiboles: implications for oxygen fugacity and water activity in lithospheric mantle beneath Victoria Land, Antarctica
- Author
- A Demény
- A Monkawa
- A Monkawa
- A Mottana
- A Zanetti
- AB Woodland
- AG Goncharov
- AH Peslier
- AH Peslier
- AV McGuire
- B Faccini
- B. Faccini
- BJ Wood
- BJ Wood
- C Ballhaus
- C Bonadiman
- C McCammon
- C Perinelli
- C Perinelli
- C. Bonadiman
- D Canil
- D Canil
- D Dolejs
- DA Carswell
- DG Pearson
- DJ Frost
- F Bosi
- F Farges
- G Chazot
- G Giuli
- G Giuli
- G Witt-Eickschen
- G. Giuli
- GM Sheldrick
- GP Brey
- GS Mattioli
- H Annersten
- HP Liermann
- HSC O’Neill
- ID Brown
- IJ Parkinson
- J Dale
- J Ganguly
- J Li
- J Nell
- J Wang
- J Zipfel
- JA Ibers
- JB Dawson
- JC Mercier
- JL Pouchou
- K Ota
- L Ottolini
- L Ottolini
- L Ottolini
- L Ottolini
- M Coltorti
- M Coltorti
- M Coltorti
- M Melchiorre
- M Quintiliani
- M Tiepolo
- M Welch
- M Wilke
- M. Coltorti
- MD Dyar
- MD Dyar
- MD Dyar
- MD Dyar
- N Morimoto
- ND Chattarjee
- NJE Pike
- P Armienti
- P Comodi
- P. Comodi
- R Oberti
- R Oberti
- RK Popp
- RV White
- RW Luth
- S Arai
- S Chakraborty
- S Klemme
- S Nazzareni
- S. Nazzareni
- SF Foley
- SF Foley
- SJ Barnes
- SY O’Reilly
- T Gasparik
- TJB Holland
- TJB Holland
- VN Sobolev
- WM Lamb
- ZXA Li
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Pharmacokinetic and Pharmacodynamic Implications of P-glycoprotein Modulation
- Author
- Akiyama S
- Alderman CP
- Aquilante CL
- Arboix M
- Arceci RJ
- Barancik M
- Barbarash RA
- Beaulieu E
- Bergmann R
- Bhat UG
- Boesch D
- Boote DJ
- Booth CL
- Callaghan R
- Chao NJ
- Chen AY
- Chen C
- Chen C
- Choo EF
- Collett A
- Combates NJ
- Cordon-Cardo C
- Cormet-Boyaka E
- Cornwell MM
- Croop JM
- Cvetkovic M
- Dale IL
- Damiani D
- Dantzig AH
- De Boer AB
- del Moral RG
- den Ouden D
- Drach D
- Fisher GA
- Fracasso PM
- Fromm MF
- Galski H
- Giaccone G
- Gianni L
- Gutmann H
- Hall SD
- Hendrikse NH
- Henthorn TK
- Herzog CE
- Hochhauser D
- Hsing S
- Huizing MT
- Huwyler J
- Hyafil F
- Ichikawa-Haraguchi M
- Ishikawa M
- Jette L
- Karlsson J
- Kim AE
- Klimecki WT
- Kusuhara H
- Kwei GY
- Letrent SP
- Loor F
- Lum BL
- Mai I
- Marbeuf-Gueye C
- Marie JP
- Marie JP
- Martin C
- Mayer U
- McCoy C
- Michieli M
- Miyama T
- Mulder HS
- Muller M
- Newman MJ
- Okamura N
- Oude Elferink RP
- Pan BF
- Peng KC
- Rahn KH
- Roots I
- Rowinsky EK
- Saeki T
- Sandstrom R
- Schiller JH
- Schiller JH
- Schinkel AH
- Schuetz EG
- Schuetz EG
- Seelig A
- Siegsmund MJ
- Slate DL
- Solary E
- Solary E
- Song S
- Spahn-Langguth H
- Srinivas RV
- Stein WD
- Stromskaya TP
- Su SF
- Takara K
- Takatori T
- Tanigawara Y
- Thorgeirsson SS
- Ueda K
- van Asperen J
- van Asperen J
- van Zuylen L
- Volm M
- Wang EJ
- Warr JR
- Watkins PB
- Weber SJ
- Weber SJ
- Woodland C
- Yamada T
- Yu L
- Yumoto R
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Complications associées à l’échocardiographie transoesophagienne
- Author
- A Dhariwal
- A Martineau
- A Moussarih Al
- A Yasick
- AC Ho
- AF Khoury
- AF Tarantal
- AJ Scriven
- AJ Vries De
- AM Nana
- AM Thompson
- André Denault
- AP Reed
- AR Hulyalkar
- AS Bensky
- AS Dajani
- Association of periOperative Registered Nurses
- AT Gurbuz
- AU Ghafoor
- AY Denault
- B Cujec
- B Dougherty Thomas
- B Lalanne
- BA Muller
- BC Aeschbacher
- BK Khandheria
- BK Khandheria
- CA Greim
- CD Polhamus
- CK Phoon
- CM Kim
- CP Shah
- CS Reuss
- CW Hogue
- D Chan
- DA Lieberman
- DA MacGregor
- DB Andropoulos
- DC Berkompas
- DC Sutton
- DC Sutton
- DE Fleischer
- DH Dunker
- DM Switz
- DR Lawrence
- DR Spahn
- E Foster
- E Foster
- E Huttemann
- E Huttemann
- ED Kharasch
- EL Carstensen
- EO Ofili
- F Beique
- F Kerbaul
- FA Flachskampf
- FF Fernandez
- G Gorge
- GD Bell
- Geneviève Côté
- GG Pattullo
- GM Janelle
- GM Novaro
- H Fujii
- H Koinig
- H Yamamoto
- HD Watts
- HJ Willens
- HK Eltzschig
- I Fergus
- I Kronzon
- IA Muhiudeen
- IA Muhiudeen-Russell
- ID Norton
- IJ Kallmeyer
- IM Leitman
- IW Black
- J Gorcsan
- J Jougon
- J Lam
- J Lam
- J Lam
- J Paiste
- J Ramjohn
- J Riazi
- J Salcedo
- J St-Pierre
- J Taillefer
- JA Rousou
- JB Lecharny
- JB Seward
- JB Seward
- JD Law-Koune
- JE Aviv
- JF Zachary
- JG Augoustides
- JG Stevenson
- JG Stevenson
- JG Stevenson
- JH Liu
- JH Urbanowicz
- JK Min
- JP Eichelberger
- JP O’Shea
- JR Rey
- JR Saphir
- JS Savino
- JS Shanewise
- JT Lutz
- JW Harvey
- JW Tam
- K Cierpka
- K Orihashi
- K Sriram
- KD Kwak
- KL Chan
- KT Spencer
- KT Spencer
- L Frazin
- LF Fagan
- LI Bezold
- LJ Martinez
- LJ Melendez
- LM Kohr
- M Brook
- M Delvaux
- M Gianni
- M Kainuma
- M Kostolny
- M Minhaj
- M Mishra
- MA Cavero
- MA Fisher
- MA Gendreau
- MA Greene
- MA Sobrino
- MB Weinger
- MC Schulmeyer
- MF El-Chami
- MF Stoddard
- MJ Ellenhorn
- MJ Lennon
- MM Zestos
- MP Zalunardo
- MS Chow
- MW Miller
- MW Pong
- MY Shapira
- N Massa
- P Couture
- P Latham
- P Vignon
- PA Marcovitz
- PC Frommelt
- PE Benedict
- PG Barash
- PJ Gregory
- PJ Hanson
- PW O’Leary
- PY Levy
- R Badaoui
- R Baggs
- R Ortega
- R Roudaut
- R Sachdeva
- R Zubarik
- RA Gal
- RF Brooker
- RF Cucchiara
- RJ Lunn
- RJ Suriani
- RJ Suriani
- RJ Suriani
- RK Tandon
- RL Click
- RL Wurdeman
- RM Mentzer
- RR Wenzel
- RS Freedberg
- RT Ho
- RV Woodland
- S BheemReddy
- S Carerj
- S Fritz
- S Garimella
- S Goland
- S Kawahito
- S Kihara
- S Nakao
- S Stienlauf
- SA Olenchock
- SC Sharma
- SE Cyran
- SE Grauer
- SE Rubesin
- SF Webb
- SG Venticinque
- SK Birchem
- Spiess BD Bruck DA
- SR Massey
- SW MacGowan
- T Hong
- T Rafferty
- T Sakai
- TB Gilbert
- TS Chee
- V Vidyarthi
- W Grosse-Heitmeyer
- W Soong
- W Wilson
- WE Dewhirst
- WG Daniel
- WJ Stewart
- WK Hirota
- WT Brinkman
- Y Takasaki
- YY Chang
- YY Han
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Renal Drug Transporters and Drug Interactions.
- Author
- A Allen
- A Amphoux
- A Aslamkhan
- A Azzariti
- A Brandoni
- A Collett
- A Courtois
- A Crowe
- A Dahan
- A Dahan
- A Dahan
- A Dahlin
- A D’Emanuele
- A Enomoto
- A Enomoto
- A Futatsugi
- A Gaowa
- A Geick
- A Gupta
- A Hamada
- A Horie
- A Kamizono
- A Kawase
- A Koenen
- A Komatsuda
- A Kunze
- A Lazar
- A Lespine
- A Maeda
- A Maeda
- A McCormick
- A Milane
- A Mulgaonkar
- A Nakayama
- A Nies
- A Oka
- A Ose
- A Owen
- A Pawarode
- A Poirier
- A Rizwan
- A Servais
- A Soldner
- A Somogyi
- A Somogyi
- A Somogyi
- A Somogyi
- A Vildhede
- A Yamada
- A Yamada
- A Yonezawa
- A Yonezawa
- AA El-Sheikh
- AA Ela El
- AA Somogyi
- AA Somogyi
- AAK El-Sheikh
- AAK El-Sheikh
- AAK El-Sheikh
- AAK El-Sheikh
- AB Shapiro
- AE Busch
- AE Herwaarden van
- AE Kim
- AG Hotchkiss
- AH Schinkel
- AH Schinkel
- AH Schinkel
- AJ Dudley
- AJ Dudley
- AJ Scheen
- AL Dzierlenga
- AL VanWert
- AL VanWert
- AL Walker
- AM Al-Mohizea
- AM Bergman
- AM Hecken van
- AN Shaik
- Anton Ivanyuk
- AR Asif
- AS Mulato
- AS Ray
- AS Windass
- AS Windass
- AT Nies
- AT Wolman
- B Astorga
- B Feng
- B Feng
- B Fleisher
- B Greiner
- B Grover
- B Grover
- B Haenisch
- B Poller
- B Wenge
- BAC Acker van
- BC Burckhardt
- BC Ferslew
- BG Hardy
- BG Hardy
- BH Long
- BJ Gurley
- BL Lum
- BL Mason
- BM Schmitt
- BP Kearney
- BR Green
- C Chen
- C Chen
- C Chu
- C Fahrmayr
- C Fellner
- C Grammen
- C Hilgendorf
- C Jacobs
- C Jagannath
- C Kasserra
- C Kyrklund
- C Li
- C Luna-Tortós
- C Marzolini
- C Min-Koo
- C Pauli-Magnus
- C Pauli-Magnus
- C Pauli-Magnus
- C Pontier
- C Schmitt
- C Srimaroeng
- C Srimaroeng
- C Wandel
- C Wandel
- C Wang
- C Woodland
- C Xu
- C Zhang
- C Zhang
- C-H Ho
- CA Flynn
- CA Quezada
- CA Stanley
- CB Landersdorfer
- CB Landersdorfer
- CC Bridges
- CC Kuo
- CC Wong
- CC Wong
- CC Wong
- CE Frost
- CF Higgins
- CG Patel
- CGL Lee
- CH Rammelkamp
- CH Storch
- CL Noble
- CL Ronchera
- CO Kim
- Consortium IT
- CR Hill
- CR Yates
- CS Karyekar
- CS Lancaster
- CS Temple
- CV Fletcher
- D Capone
- D Cihalova
- D Devineni
- D Durr
- D Gründemann
- D Gründemann
- D Gründemann
- D Gründemann
- D Iusuf
- D Jung
- D Keppler
- D Lawlor
- D Li
- D Miura
- D Overbosch
- D Schrenk
- D Schwab
- D Siccardi
- D Taubert
- D Vishnuvardhan
- D Wang
- D Werner
- D Zhang
- Dai Cl
- DB Kell
- DE Burgio
- DE Martin
- DG Bailey
- DH Sweet
- DH Sweet
- DH Sweet
- DH Sweet
- DJ Tompson
- DL Bourdet
- DM Moss
- DM Truong
- DN Fish
- DS Miller
- DS Miller
- DW Boulton
- E Babu
- E Babu
- E Bakos
- E Cormet-Boyaka
- E Gozalpour
- E Kamiyama
- E Kimoto
- E Pasquier
- E Rytting
- E Rytting
- E Schwob
- E Stormer
- E Waller
- E-I Lepist
- E-S Jeong
- EE Robertson
- EF Choo
- EF Foote
- EG Schuetz
- EI Lepist
- EJ Guest
- EJ Wang
- EJ Wang
- EJ Wang
- EL Mariño
- EL Reyner
- EM Choi
- ES Oh
- F Faassen
- F Gimenez
- F Gutierrez
- F Leonessa
- F Müller
- F Müller
- F Pietruck
- F Shen
- F Tang
- F Tang
- F Trejtnar
- F Yamashita
- F Zhou
- FA Bainbridge
- FA Jong de
- FE O’Brien
- FE O’Brien
- FGM Russel
- FGM Russel
- Françoise Livio
- G Adamis
- G An
- G Ciarimboli
- G Ciarimboli
- G Ciarimboli
- G Ciarimboli
- G DiDiodato
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- ZS Chen
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- ZS Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/08/2017
- Field of study
Transporters in proximal renal tubules contribute to the disposition of numerous drugs. Furthermore, the molecular mechanisms of tubular secretion have been progressively elucidated during the past decades. Organic anions tend to be secreted by the transport proteins OAT1, OAT3 and OATP4C1 on the basolateral side of tubular cells, and multidrug resistance protein (MRP) 2, MRP4, OATP1A2 and breast cancer resistance protein (BCRP) on the apical side. Organic cations are secreted by organic cation transporter (OCT) 2 on the basolateral side, and multidrug and toxic compound extrusion (MATE) proteins MATE1, MATE2/2-K, P-glycoprotein, organic cation and carnitine transporter (OCTN) 1 and OCTN2 on the apical side. Significant drug-drug interactions (DDIs) may affect any of these transporters, altering the clearance and, consequently, the efficacy and/or toxicity of substrate drugs. Interactions at the level of basolateral transporters typically decrease the clearance of the victim drug, causing higher systemic exposure. Interactions at the apical level can also lower drug clearance, but may be associated with higher renal toxicity, due to intracellular accumulation. Whereas the importance of glomerular filtration in drug disposition is largely appreciated among clinicians, DDIs involving renal transporters are less well recognized. This review summarizes current knowledge on the roles, quantitative importance and clinical relevance of these transporters in drug therapy. It proposes an approach based on substrate-inhibitor associations for predicting potential tubular-based DDIs and preventing their adverse consequences. We provide a comprehensive list of known drug interactions with renally-expressed transporters. While many of these interactions have limited clinical consequences, some involving high-risk drugs (e.g. methotrexate) definitely deserve the attention of prescribers
Renal Drug Transporters and Drug Interactions
- Author
- A Allen
- A Amphoux
- A Aslamkhan
- A Azzariti
- A Brandoni
- A Collett
- A Courtois
- A Crowe
- A Dahan
- A Dahan
- A Dahan
- A Dahlin
- A D’Emanuele
- A Enomoto
- A Enomoto
- A Futatsugi
- A Gaowa
- A Geick
- A Gupta
- A Hamada
- A Horie
- A Kamizono
- A Kawase
- A Koenen
- A Komatsuda
- A Kunze
- A Lazar
- A Lespine
- A Maeda
- A Maeda
- A McCormick
- A Milane
- A Mulgaonkar
- A Nakayama
- A Nies
- A Oka
- A Ose
- A Owen
- A Pawarode
- A Poirier
- A Rizwan
- A Servais
- A Soldner
- A Somogyi
- A Somogyi
- A Somogyi
- A Somogyi
- A Vildhede
- A Yamada
- A Yamada
- A Yonezawa
- A Yonezawa
- AA El-Sheikh
- AA Ela El
- AA Somogyi
- AA Somogyi
- AAK El-Sheikh
- AAK El-Sheikh
- AAK El-Sheikh
- AAK El-Sheikh
- AB Shapiro
- AE Busch
- AE Herwaarden van
- AE Kim
- AG Hotchkiss
- AH Schinkel
- AH Schinkel
- AH Schinkel
- AJ Dudley
- AJ Dudley
- AJ Scheen
- AL Dzierlenga
- AL VanWert
- AL VanWert
- AL Walker
- AM Al-Mohizea
- AM Bergman
- AM Hecken van
- AN Shaik
- Anton Ivanyuk
- AR Asif
- AS Mulato
- AS Ray
- AS Windass
- AS Windass
- AT Nies
- AT Wolman
- B Astorga
- B Feng
- B Feng
- B Fleisher
- B Greiner
- B Grover
- B Grover
- B Haenisch
- B Poller
- B Wenge
- BAC Acker van
- BC Burckhardt
- BC Ferslew
- BG Hardy
- BG Hardy
- BH Long
- BJ Gurley
- BL Lum
- BL Mason
- BM Schmitt
- BP Kearney
- BR Green
- C Chen
- C Chen
- C Chu
- C Fahrmayr
- C Fellner
- C Grammen
- C Hilgendorf
- C Jacobs
- C Jagannath
- C Kasserra
- C Kyrklund
- C Li
- C Luna-Tortós
- C Marzolini
- C Min-Koo
- C Pauli-Magnus
- C Pauli-Magnus
- C Pauli-Magnus
- C Pontier
- C Schmitt
- C Srimaroeng
- C Srimaroeng
- C Wandel
- C Wandel
- C Wang
- C Woodland
- C Xu
- C Zhang
- C Zhang
- C-H Ho
- CA Flynn
- CA Quezada
- CA Stanley
- CB Landersdorfer
- CB Landersdorfer
- CC Bridges
- CC Kuo
- CC Wong
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- CC Wong
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- CF Higgins
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- CL Noble
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- CO Kim
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- CV Fletcher
- D Capone
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- G Ciarimboli
- G DiDiodato
- G He
- G Hill
- G Jayasagar
- G Kaler
- G Koren
- G Liu
- G Merino
- G Minuesa
- G Pan
- G Peytavin
- G Pottier
- G Reid
- G Reid
- GA Kullak-Ublick
- GC Williams
- GG Belz
- GJR Zaman
- GK Dresser
- GW Aherne
- H Chanteux
- H Duan
- H Endou
- H Fujimoto
- H Fujino
- H Gutmann
- H Hasannejad
- H Hasannejad
- H Honjo
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- H Komazawa
- H Kusuhara
- H Kusuhara
- H Kusuhara
- H Li
- H Liu
- H Matsuo
- H Matsuo
- H Motohashi
- H Motohashi
- H Nagy
- H Omote
- H Saitoh
- H Saitoh
- H Sasabe
- H Sato
- H Shen
- H Shen
- H Sun
- H Tahara
- H Tahara
- H Ueo
- H Yabuuchi
- H Yamaguchi
- H Yoon
- H Yuan
- H-K Lee
- HC Liu
- HE Jin
- HE Mellin
- HE Meyer zu Schwabedissen
- HH Kalsi
- HH Lee
- HJ Shin
- HM Faessel
- HM Kauffmann
- I Bachmakov
- I Badagnani
- I Ieiri
- I Ieiri
- I Ifergan
- I Leier
- I Massimi
- I Robieux
- I Tamai
- I Tamai
- I Tamai
- I Yano
- I-S Song
- IA Hauser
- IS Haslam
- IS Haslam
- IS Haslam
- IS Song
- IS Song
- IY Gong
- J Bai
- J Bentz
- J Biermann
- J Brillault
- J Crugten van
- J Cusato
- J Enokizono
- J Gao
- J He
- J Hunter
- J Knop
- J Knop
- J Koteff
- J Lee
- J Li
- J Li
- J Li
- J Lu
- J Mandikova
- J Mandíková
- J Müller
- J Naud
- J Oh
- J Rengelshausen
- J Rengelshausen
- J Shen
- J Shimada
- J Souza de
- J Stangier
- J Taipalensuu
- J Thomas
- J Weiss
- J Weiss
- J Weiss
- J Weiss
- J Weiss
- J Ye
- J Ye
- J Yin
- J Zhang
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