The Information Coded in the Yeast Response Elements Accounts for Most of the Topological Properties of Its Transcriptional Regulation Network

The regulation of gene expression in a cell relies to a major extent on transcription factors, proteins which recognize and bind the DNA at specific binding sites (response elements) within promoter regions associated with each gene. We present an information theoretic approach to modeling transcriptional regulatory networks, in terms of a simple “sequence-matching” rule and the statistics of the occurrence of binding sequences of given specificity in random promoter regions. The crucial biological input is the distribution of the amount of information coded in these cognate response elements and the length distribution of the promoter regions. We provide an analysis of the transcriptional regulatory network of yeast Saccharomyces cerevisiae, which we extract from the available databases, with respect to the degree distributions, clustering coefficient, degree correlations, rich-club coefficient and the k-core structure. We find that these topological features are in remarkable agreement with those predicted by our model, on the basis of the amount of information coded in the interaction between the transcription factors and response elements

An Evaluation of Fracture Strength of Zirconium Oxide Posts Fabricated Using CAD-CAM Technology Compared with Prefabricated Glass Fibre Posts

Post and core therapy is regarded as the treatment of choice for restoring severely damaged endodontically treated teeth. Critical control of endodontic materials in the coronal third of the canal and pulp chamber is essential in order to maintain its colour and translucency. In addition to this, the duplication of the optical characteristics of an intact tooth, including shade translucency and fluorescence is often made difficult by the use of metal infrastructures. As a result of this tooth colored posts have gained popularity especially in aesthetic areas. Besides aesthetics, the post is also responsible for transmitting the occlusal forces to the remaining tooth structure making the mechanical properties of the post critical. However, there is no clear consensus regarding an ideal system as far as strength of the post is concerned. Hence this study aims to analyses and compares the fracture strength of traditional prefabricated glass fibre posts with zirconium oxide posts constructed using CAD CAM technology