2,487 research outputs found
METHODS TO INVESTIGATE HYPERTHERMIA INDUCED BY TUMOR TREATING FIELDS
Tumor Treating Fields (TTFields) are an antineoplastic treatment delivered via application of alternating electric fields using insulated transducer arrays placed directly on the skin in the region surrounding the tumor. TTF’s is a non-invasive application of low-intensity (1-3 V/cm), intermediate-frequency (100-500 kHz) alternating electric fields. The predominant mechanism by which TTFields are thought to kill tumor cells is the disruption of mitosis through the depolymerization of microtubules and interruption of the spindle structure leading to mitotic catastrophe and the formation of non-viable daughter cells. Tumor Treating fields do not stimulate nerves and muscle because of their high frequency, and do not generate heat because of their low intensity. However, there is no study to support the mechanism of TTF’s. It is still under research. There is not much research done on the hyperthermia induced by tumor treating fields. It’s still not known whether heat also plays a role in inhibiting cancer growth and killing cancer cells. Our hypothesis is that the TTF’s at 150 kHz frequency induce hyperthermia in pancreatic cancer cells. Two specific aims are set to approach this hypothesis. First specific aim is to design and develop an engineering set up capable of generating frequency with amplitude modulation to induce TTF’s (150kHz). And second aim is to perform experiments on panc-1 cells stained with PEG BODIPY dye cultured in a custom designed Delta T dish using picoquant confocal microscope. Lifetime measurement of the dye clearly suggests that temperature does increase in the cells with time
The role of HR practices in the process of employer branding – a case of UK data centre industry
Genome-wide Insilico analysis of plant two component signaling system in woody model plant Populus trichocarpa
The two-component system (TCS) which works on the principle of histidine-aspartate phosphorelay signaling, is known to play an important role in diverse physiologicalprocesses in lower organisms and emerged as an important signaling system in both prokaryotic as well as eukaryotic systems including plants. Employing various bioinformatics tools, we have characterized TCS signaling candidate genes in the genome of Populus trichocarpa. In this study we present an overview of TCS gene families in P. tricocarpha, including gene structures, conserved motifs, chromosome locations, andphylogeny. This analysis indicates a total of 49 genes out of which at least 12 belongs tohistidine kinases (8 histidine kinase (PtHK) and 4 ethylene responsive (PtETR)), 12 pseudo phosphotransfers(PtHPT) and 9 type-A(PtRRA), 11 type-B (PtRRB), and 5 pseudo-responseregulator proteins (PtPRR) present on different chromosomes. Fourteen genes encode 22putative histidine kinases with a conserved histidine and other typical histidine kinasesignature sequences, five phosphotransfer genes encoding seven phosphotransfer proteins,and 32 response regulator genes encoding 44 proteins. Structural and phylogenetic analysesof populous TCS members with their Arabidopsis and rice counterparts revealed similararchitecture of their TCSs. Our analysis provides insights into the conservation anddivergence of this important signaling machinery in woody plants
Fixed Point Result in Probabilistic Metric Space
In this paper we prove common fixed point theorem for four mapping with weak compatibility in probabilistic metric space. Keywords: Menger space, Weak compatible mapping, Semi-compatible mapping, Weakly commuting mapping, common fixed point. AMS Subject Classification: 47H10, 54H25
Operative Merest-undertaking Impeccable Reclamation Line Accretion Ordering for Deterministic Mobile Distributed Computing Systems
Impeccable-RL-accretion (Impeccable Reclamation Line accretion) is one of the ordinarily familiarized approaches to present failing resilience in Distributed Computing setup (DCS) so that the setup can operate even if one or more components have abdicated. However, Mobile DCSs are constrained by small transmittal potentiality, Suppleness, and dearth of stabilized repository, recurrent disruptions and imperfect battery life. From this time Impeccable-RL-accretion orderings which have reduced reestablishment-dots are favored in mobile environments. In this paper, we contemplate a merest-undertaking synchronic ordering for Impeccable-RL-accretion for mobile DCS. We eliminate inoperable reestablishment-dots as well as stalling of undertakings amidst reestablishment-dots at the striving of registering contra-dispatches of very few dispatches amidst Impeccable-RL-accretion. We also organize an effort to subside the depletion of Impeccable-RL-accretion work when any undertaking collapses to stockpile its reestablishment-dot in a founding. In this mode, we handle excessive failings amidst Impeccable-RL-accretion. We organize registering of contra-dispatches of very few dispatches only amidst Impeccable-RL-accretion. We also strive to subside depletion of Impeccable-RL-accretion work.
 
Recent advances of biosensors in biomedical sciences
This review discusses recent advances in biosensor technology which draw on the disciplines of physics, chemistry, biochemistry and electronics. We first show that a biosensor consists of three components, a biological detection system, a transducer and an output system. Biological receptors are reviewed, followed by a detailed discussion of transducers, optical, electrochemical, piezoelectric, and others which involve interesting physics and show particular promise for commercial biosensors, are discussed thoroughly. New developments in biosensor design are appearing at a high rate as these devices play increasingly important roles in daily life. We describe a new technology, the Ibis T5000, for the identification of pathogens in clinical and environmental samples; a novel ion channel switch biosensor (ICSB), offers a rapid and sensitive immunodiagnostic for viral detection at point-of care; Chip-NMR, new diagnostic platforms have been developed to measure biomolecule abundance with high sensitivity; Graphene has attracted strong scientific and technological interest in recent years. Finally, future trends in biosensor development are discussed. In this context, bioelectronics, miniaturization, and especially biotechnology seem to be growing areas that will have a marked influence on the development of new biosensing strategies in the next future
A Review on Maximum Power Point Tracking (MPPT) Technique for PV Power Generation System
The growing concern on environmental issues caused by fossil fuels and, indeed, on the availability of such energy resources in a long-run basis have settled the ground for the spreading of the so-called green energy sources. Among them, photovoltaic energy stands out due to the possibility of turning practically any household into a micro power plant. One important aspect about this source of energy is that practical photovoltaic generators are equipped with maximum power point tracking (MPPT) systems. Currently, researchers are focused on developing MPPT algorithms for partial shaded panels. In this paper review is presented on the emerging topologies for PV applications that could be used in the generation of new smart inverters
Evaluation of Representative Smart Grid Investment Grant Project Technologies: Distributed Generation
This document is one of a series of reports estimating the benefits of deploying technologies similar to those implemented on the Smart Grid Investment Grant (SGIG) projects. Four technical reports cover the various types of technologies deployed in the SGIG projects, distribution automation, demand response, energy storage, and renewables integration. A fifth report in the series examines the benefits of deploying these technologies on a national level. This technical report examines the impacts of addition of renewable resources- solar and wind in the distribution system as deployed in the SGIG projects
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