17 research outputs found
Case Report Beneficial Effect of Conversion to Belatacept in Kidney-Transplant Patients with a Low Glomerular-Filtration Rate
Belatacept has been found to be efficient at preserving good kidney function in maintenance kidney-transplant patients. Herein, we report on the use of belatacept as a rescue therapy for two kidney-transplant patients presenting with severe adverse events after treatment with calcineurin inhibitors (CNIs) and mammalian target-of-rapamycin (mTOR) inhibitors. Two kidney-transplant patients developed severely impaired kidney function after receiving CNIs. The use of everolimus was associated with severe angioedema. Belatacept was then successfully used to improve kidney function in both cases, even though estimated glomerularfiltration rate before conversion was <20 mL/min. These case reports show that belatacept can be used as a rescue therapy, even if kidney function is very low in kidney-transplant patients who cannot tolerate CNIs and/or mTOR inhibitors
La dialyse péritonéale
AIX-MARSEILLE2-BU Pharmacie (130552105) / SudocSudocFranceF
Contactless diamagnetic trapping of living cells onto a micromagnet array
ISBN: 978-1-4244-1814-5International audienceThis paper focuses on the application of magnetophoresis to a new cell patterning method. The principle was demonstrated by using a CoPt micromagnet array, producing regularly spaced magnetic traps where cells were confined without any contact under the effect of negative magnetophoresis. To obtain this effect, yeast cells (Saccharomyces cerevisiae), which are diamagnetic, were placed in an aqueous solution enriched in paramagnetic ions. Unlabeled (non-magnetic) cell manipulation by magnetophoresis requires the production of high magnetic field gradients, ensuring significant forces. Therefore, micromagnets are particularly interesting for our application, since the field gradient increases as magnet dimensions are reduced
Beneficial Effect of Conversion to Belatacept in Kidney-Transplant Patients with a Low Glomerular-Filtration Rate
Belatacept has been found to be efficient at preserving good kidney function in maintenance kidney-transplant patients. Herein, we report on the use of belatacept as a rescue therapy for two kidney-transplant patients presenting with severe adverse events after treatment with calcineurin inhibitors (CNIs) and mammalian target-of-rapamycin (mTOR) inhibitors. Two kidney-transplant patients developed severely impaired kidney function after receiving CNIs. The use of everolimus was associated with severe angioedema. Belatacept was then successfully used to improve kidney function in both cases, even though estimated glomerular-filtration rate before conversion was <20 mL/min. These case reports show that belatacept can be used as a rescue therapy, even if kidney function is very low in kidney-transplant patients who cannot tolerate CNIs and/or mTOR inhibitors
Meso-photonic detection with HgCdTe APDs at high count rates
International audienceThe characterization results and analysis from the detection of meso-photonic laser pulses,characterized by zero to tens of photons per pulse, using an in-house developed detector modulebased on HgCdTe avalanche photodiodes (APDs) are reported. In this detector module, HgCdTe APDsis hybridized to a specifically developed Si CMOS amplifier circuit with a low input noise and highbandwidth of 400 MHz that is shown to be capable of detecting single photon events at APD gain inexcess of 100. The use of a Si CMOS amplifier with a high bandwidth is crucial to detect pulsed signalsat high rates. With the present detector, this has enabled to detect temporally distinguishable singlephoton events up to a record rate of 500 MHz on a single solid-state detector. The capacity of thedetector to characterize mesoscopic light states was demonstrated on an input state of an average ofµ=1.6 photons using a fitting procedure to extract the timing and amplitude of each pulse. Thisanalog approach to analyze the detection of meso-photonic light is shown to be efficient to estimatethe attenuated photon state and to calibrate detector characteristics such as the event detectionefficiency (87 %), the multiplication gain distribution and corresponding excess noise factor (F=1.33)and the timing jitter distribution with a full width half maximum of FWHM=277 ps
HgCdTe APDs detector developments at CEA/Leti for atmospheric lidar and free space optical communications
Event: International Conference on Space Optics - ICSO 2018, 2018, Chania, GreeceInternational audienc
Des jeunes à la marge ?
Dans les travaux français de la sociologie de la jeunesse, la question du genre comme processus d’assignation sexuée des pratiques et des représentations, renouvelant la lecture des rapports sociaux de domination, n’est apparue que récemment. Poursuivant l’interrogation initiale des premières Rencontres Jeunes & Sociétés sur « les cadres et les modalités de la socialisation sexuée », cet ouvrage analyse les marginalités et les déviances juvéniles à l’égard des normes de genre. Les contributions étudient les modalités de production de pratiques et de représentations dont les contours, rapportés à l’ordre du genre et à ses critères de classements, ses catégorisations et ses comptages, tracent des groupes minoritaires, parfois placés sous un contrôle institutionnel qui marque l’évaluation d’une possible dangerosité sociale. Il s’agit donc moins de comprendre la reproduction des clivages sexués, que d’analyser la recomposition des marges du genre en même temps que le processus de normalisation qui fait des déviances d’hier, les normes d’aujourd’hui
Enfermements. Volume III
Pourquoi conçoit-on des lieux fermés pour les hommes et d’autres pour les femmes ? En quoi les discours autour du genre ont-ils influencé l’émergence et la perpétuation de dispositifs de clôture pour affirmer les différences sociales entre hommes et femmes ? Quelles formes prennent les rapports entre les sexes dans les milieux clos ? Associant des approches historiques et sociologiques, cet ouvrage explore les interactions entre les différentes formes d’enfermements et le genre, ce qui induit une réflexion sur le féminin, sur le masculin et sur leurs interrelations dans les conditions créées par une séparation plus ou moins rigoureuse du monde. Les études de cas rassemblées dans ce volume entendent comprendre tant les effets que la clôture a produits et produit sur les conceptions du genre que, à l’inverse, les effets que le genre a produits et produit sur la clôture. Les rapports qu’entretiennent genre et enfermement sont envisagés sur la longue durée de l’histoire européenne, depuis les monastères médiévaux et les hôpitaux d’Ancien Régime jusqu’aux institutions pénitentiaires, bagnes et camps contemporains. L’ouvrage montre également leur résonance dans des territoires coloniaux d’Amérique et dans le monde chrétien de la Méditerranée orientale. Il révèle ainsi que les lieux clos sont des lieux matriciels où se sont élaborés et s’élaborent des pratiques, des techniques et des savoirs autour du féminin et du masculin
A candidate gene approach of the calcineurin pathway to identify variants associated with clinical outcomes in renal transplantation
© 2016 Future Medicine Ltd.Aim: To investigate the potential influence of variants in genes involved in the calcineurin pathway on the efficacy and toxicity of calcineurin inhibitors in renal transplantation. Materials & methods: Twenty-three polymorphisms in thirteen genes were tested in 381 renal transplant recipients receiving ciclosporin (n = 221) or tacrolimus (n = 160) and mycophenolate mofetil. Data were collected prospectively over the first year post-transplantation. Results: Multivariate survival analyses revealed no genetic associations with biopsy proven acute graft rejection and serious infections. Donor-recipient Cytomegalovirus mismatch was the only variable associated with serious infection. Conclusion: This large exploratory study casts doubts on the potential interest of genetic biomarkers related to CNI pharmacodynamics but associations with other phenotypes in transplantation deserve further studies
Entre les murs / Hors les murs
Depuis plus de trois dĂ©cennies, les musĂ©es ont connu de profondes Ă©volutions dans le regard portĂ© sur le public. Celui-ci se dĂ©cline aujourd’hui au pluriel, est analysĂ© au travers de ses attentes, de ses motivations, de ses traits spĂ©cifiques. Les institutions ont pourtant depuis longtemps conscience qu’une part importante de la population ne les frĂ©quente pas et n’envisage pas de les frĂ©quenter. Depuis la dĂ©nonciation des « non-publics » en 1968 jusqu’à l’attention rĂ©cente pour les publics les plus Ă©loignĂ©s de la culture institutionnelle (publics Ă©loignĂ©s, empĂŞchĂ©s, en difficultĂ©, dĂ©favorisĂ©s, etc.), une dialectique complexe, Ă propos de ces publics atypiques, se redĂ©finit sans cesse sur l’art comme Ă©cart et la dimension inclusive de l’action culturelle, sur les lieux de l’action culturelle, entre les murs et hors les murs. Ces murs sont ceux de l’institution mais aussi ceux, subis et intĂ©riorisĂ©s, qui rendent impossible l’exercice d’un droit fondamental : l’accès Ă la culture. Ce numĂ©ro est consacrĂ© aux publics dits « empĂŞchĂ©s », notamment aux nouvelles cibles de l’action culturelle, dans les prisons, les centres fermĂ©s et les hĂ´pitaux. Comment ces publics sont-ils qualifiĂ©s, construits par les actions artistiques et culturelles proÂposĂ©es par les institutions ? Quels sont les enjeux de ces actions ? Comment la recherche peut-elle s’en saisir pour repenser les logiques de dĂ©mocratisation et de dĂ©mocratie culturelles ? For over three decades, museums have undergone a profound transformation in its attitude towards its audience. These days, this term is used in the plural and analyzed according to their expectations, motivations and specific traits. Institutions have nonetheless been long aware that an important section of the population is not amongst its visitors and has no plans to be. From the naming of “non-audiences” in 1968 to the recent attention given to audiences the most far removed from cultural institutions (geographically distant, impeded or hindered in their visit, disabled visitors, etc.), a complex reasoning concerning these atypical audiences is constantly being redefined in terms of art as difference and the inclusive nature of cultural action on institutions, both on site and off site. These are both the sites of institutions, but also, in a figurative sense, those, for reasons imposed or internalized, that prevent audiences from exercising their fundamental right to have access to culture. This issue is devoted to audiences referred to as “hindered”, especially those that are the targets of cultural action, in prisons, closed centers and hospitals. How are these audiences defined and constructed by the cultural and artistic initiatives undertaken by institutions? What issues are being tackled in these initiatives? In what ways can research take hold of these initiatives in order to rethink certain mechanisms of the democratization, and democracy, of culture