Management of osteonecrosis of the jaws induced by radiotherapy in oncological patients: preliminary results

Abstract OBJECTIVE: Osteoradionecrosis (ORN) is a bone aseptic necrosis which develops on post-irradiated bone tissue of patients who underwent radiotherapy for head-neck tumors. The mandible presents a higher risk to develop ORN, if compared to the maxillary bone, due to its lower vascularization. The aim of the present study is to clinically assess the regenerative ability by the epithelial and connective tissues, in response to ORN onset. PATIENTS AND METHODS: Authors have verified the importance of the surgical-pharmacological treatment, as an effective protocol for eliminating the exposed bone sequestration, as well as the teeth eventually damaged by the radiotherapy, assessing that the epithelium can regenerate only on healthy and vital tissues. RESULTS: The reported patient underwent resection of a portion of the left mandible with an incomplete healing after the surgery. A second curettage was scheduled in order to remove the bands of necrotic tissue and to obtain a clinical remission of symptoms. CONCLUSIONS: In patients undergoing radiotherapy, the dental surgeon should be able to give an early diagnosis of the dental and maxillofacial related pathologies; he should also detect all the possible infective sources and administer any possible treatment in a short time, before the beginning or the prosecution of radiotherapy

The co-existence of transcriptional activator and transcriptional repressor MEF2 complexes influences tumor aggressiveness

The contribution of MEF2 TFs to the tumorigenic process is still mysterious. Here we clarify that MEF2 can support both pro-oncogenic or tumor suppressive activities depending on the interaction with co-activators or co-repressors partners. Through these interactions MEF2 supervise histone modifications associated with gene activation/repression, such as H3K4 methylation and H3K27 acetylation. Critical switches for the generation of a MEF2 repressive environment are class IIa HDACs. In leiomyosarcomas (LMS), this two-faced trait of MEF2 is relevant for tumor aggressiveness. Class IIa HDACs are overexpressed in 22% of LMS, where high levels of MEF2, HDAC4 and HDAC9 inversely correlate with overall survival. The knock out of HDAC9 suppresses the transformed phenotype of LMS cells, by restoring the transcriptional proficiency of some MEF2-target loci. HDAC9 coordinates also the demethylation of H3K4me3 at the promoters of MEF2-target genes. Moreover, we show that class IIa HDACs do not bind all the regulative elements bound by MEF2. Hence, in a cell MEF2-target genes actively transcribed and strongly repressed can coexist. However, these repressed MEF2-targets are poised in terms of chromatin signature. Overall our results candidate class IIa HDACs and HDAC9 in particular, as druggable targets for a therapeutic intervention in LMS

Postfordismo e trasformazione urbana.Casi di recupero dei vuoti industriali e indicazioni per le politiche nel territorio torinese

Il volume sulle aree dismesse e la trasformazione urbana promosso dalla Direzione Competitività della Regione Piemonte e dall'ente strumentale di ricerca economica e sociale, IRES Piemonte, racchiude contributi su esperienze di recupero dei vuoti urbani industriali e casi rilevanti della trasformazione urbana che hanno interessato Torino e la sua area metropolitana.- Prefazione #7- Introduzione #9- 1. Le ristrutturazioni industriali e il territorio: crisi, declino,metamorfosi? #33- 2. Scoprire i vuoti industriali: analisi e riflessioni a partire da censimenti e mappature di aree industriali dismesse a Torino #51- 3. Le aree dismesse nella riqualificazione e nella rigenerazione urbana a Torino (1990-2015) #113- 4. La trasformazione urbana tra grandi interventi e architetture “ordinarie”. #147- 5. Due esperienze di rigenerazione urbana sul territorio torinese:il Comitato Parco Dora sulla Spina 3 e il Comitato Urban in Barriera di Milano, a Torino #169- 6. Da cittadella industriale a Spina 3: una riconversione incompiuta #193- 7. Ex Diatto - Ex Westinghouse, due casi emblematici per le politiche di rivitalizzazione delle aree industriali torinesi #211- 8. Mirafiori. Dalla componentistica allo yogurt: storia di un progetto di re-industrializzazione #229- 9. Area OSI OVEST-NORD: Toolbox Coworking! #247- 10. Abilitare il territorio metropolitano alla rigenerazione e ad un nuovo sviluppo. Il caso di None, dall'industria subita all'industria inseguita #275- 11. Le ex-Acciaierie Mandelli di Collegno: la storia di una fabbrica,l'attualità del dibattito urbanistico. #301- 12. I programmi territoriali quale motore di rigenerazione urbana e di politiche di contenimento del consumo di suolo nel comune di Settimo Torinese #323- 13. La Regione Piemonte e la sfida del contenimento del consumo di suolo e del riutilizzo delle aree dismesse #353- 14. Torino, la nascita della città postindustriale: quale bilancio? #365- 15. Valutare i rischi della riqualificazione urbanistica e ambientale delle aree industriali dismesse #381- 16. Le aree industriali dismesse e il loro impatto sulla salute: il ruolo dei cittadini e delle amministrazioni locali nell'identificazione dei problemi e delle possibili soluzioni. #405- 17. I giovani e la città che cambia. Nuovi passi e nuovi sguardi sulle tracce di un passato industriale #427- Elenco degli autori e delle autrici #44

Maria Nallino (1908-1974) and the Birth of Arabic and Islamic studies at Ca’ Foscari

This essay, based on bibliographic and archival material, focuses on the academic figure Maria Nallino, a scholar whose voluminous body of work ranges from classicism to modernity with equal fluency and expertise. Daughter of the famous Orientalist Carlo Alfonso Nallino (1872-1938), whose work she gathered and actively promoted, her arrival at Ca’ Foscari (1962) inaugurated Arabic and Islamic studies in Venice

CUBES : the Cassegrain U-band Efficient Spectrograph

In the era of Extremely Large Telescopes, the current generation of 8-10m facilities are likely to remain competitive at ground-UV wavelengths for the foreseeable future. The Cassegrain U-Band Efficient Spectrograph (CUBES) has been designed to provide high-efficiency (> 40%) observations in the near UV (305-400 nm requirement, 300-420 nm goal) at a spectral resolving power of R >20, 000 (with a lower-resolution, sky-limited mode of R ~7, 000). With the design focusing on maximizing the instrument throughput (ensuring a Signal to Noise Ratio (SNR) ~20 per high-resolution element at 313 nm for U ~18.5 mag objects in 1h of observations), it will offer new possibilities in many fields of astrophysics, providing access to key lines of stellar spectra: a tremendous diversity of iron-peak and heavy elements, lighter elements (in particular Beryllium) and light-element molecules (CO, CN, OH), as well as Balmer lines and the Balmer jump (particularly important for young stellar objects). The UV range is also critical in extragalactic studies: the circumgalactic medium of distant galaxies, the contribution of different types of sources to the cosmic UV background, the measurement of H2 and primordial Deuterium in a regime of relatively transparent intergalactic medium, and follow-up of explosive transients. The CUBES project completed a Phase A conceptual design in June 2021 and has now entered the detailed design and construction phase. First science operations are planned for 2028

OSTEOPOROSIS TREATMENT AND DENTAL CARE

Abstract Osteoporosis is characteristic pathology of the elderly. The World Health Organization utilizes the Bone Mineral Density (BMD) of the lumbar spine or proximal femur to assess the loss of bone density. Maxillary and mandibular bones show the highest turnover and the analysis of their bone density may allow an early assessment and early prevention of osteoporosis. The treatment of osteoporosis makes use of various drugs, including bisphosphonates. These may be administered by OS or IV. These drugs are very effective but may cause osteonecrosis of the jaw mainly teeth extractions. It’s therefore necessary a proper clinical evaluation by the prescribing physician, adequate information of the patient and a close collaboration with the dentist before and during treatment with bisphosphonate

Oral health status of elderly people in Rome-Italy

Background: Actually there is no survey on the oral health of elderly in Lazio region or in Rome. Study aims to assess the dental and oral health status and treatments needs of the elderly population in Rome in order to assess need for care. Materials and Methods: 316 non institutionalized patients all living in Rome underwent a complete oral and dental examination following the WHO's criteria. Statistical analysis was performed using SPSS Inc, ver. 13.0, Chicago, IL, USA. A p-value of less than 0.05 was considered significant. Results: The prevalence of edentulousness was 4.4%. Missing teeth were 3346 (37,81%). After grouping patients by age (65-69, 70-74, 75-79, 80 and over) we found that only in the first group (65-69) women had a lower number (p<0.001) of missing teeth than men: women 359 (23,31%), men 393 (35,08%). Mean number of remaining teeth per subject was 17,41. Both genders in the mandible presented a greater number of teeth present (9.02 on average) than the maxilla (8.27 on average; p=0.002). Decayed, Missing, Filled Teeth index (DMFT index) was 14.65 (D:7,73%, M:81,57% and F:10,69%.). Regarding Community Periodontal Index (CPI) 14,5% of the sextants resulted healthy, 4.9% had gingival bleeding on probing, 20.7% had dental calculus, 17.0% periodontal pockets 4-5mm deep, 1.4% pockets 6 or more mm deep and 41.5% of the sextants were excluded. Conclusions: The findings illustrated a promising oral and dental health status compared to other European countries. The status of oral health was significantly better in women than in men in the first age group 65-69, increase in age results in a worsening of all indices