Fertilizante de liberação lenta no desenvolvimento de mudas de Eucalyptus grandis.

Uma das ações mais importantes para aumentar a produção de mudas de essências florestais é a fertilização do substrato. A utilização de fertilizante de liberação lenta (FLL) pode contribuir para a obtenção de mudas de melhor qualidade. O objetivo do trabalho foi avaliar doses crescentes de FLL e fertilizante convencional (FC), bem como comparar esses fertilizantes no desenvolvimento de mudas de Eucalyptus grandis. O estudo foi realizado na região do Vale do Itajaí, SC. Os tratamentos foram a adição de FLL e FC para cada experimento nas seguintes doses de formulado: T1 ? 0 kg (testemunha); T2 ? 2 kg; T3 ? 4 kg; T4 ? 6 kg; T5 ? 8 kg e T6 ? 10 kg.m-3 de substrato-base. Decorridos 174 dias da semeadura, foram analisadas as variáveis altura total, diâmetro do colo, biomassa fresca da parte aérea, biomassa seca da parte aérea, biomassa seca da raiz, biomassa seca total, dose de máxima eficiência técnica e teores de nutrientes da parte aérea das mudas de cada tratamento. Em todos os tratamentos houve resposta positiva no desenvolvimento das mudas, entretanto as mudas tiveram melhor crescimento sob doses entre 9,1 e 12,9 kg.m-3 de fertilizante de liberação lenta

Fertilizaçao de liberação lenta no crescimento de mudas de paricá em viveiro.

A utilização da fertilização de liberação lenta (FLL) pode contribuir para a obtenção de mudas de melhor qualidade, diante de um setor habituado à utilização de fertilizantes comerciais. O objetivo desse trabalho foi avaliar doses de FLL no crescimento de mudas de paricá e a comparar o custo na produção do uso de adubo convencional em relação ao custo com FLL. O delineamento experimental foi inteiramente casualizado com seis tratamentos em quatro repetições de 40 plantas, sendo um controle e os demais com adição de diferentes doses de FLL por m³ de substrato utilizado para a produção de mudas. Decorridos 81 dias da semeadura, foram analisadas as variáveis altura total, diâmetro do colo, biomassa fresca da parte aérea, biomassa seca da parte aérea, biomassa seca da raiz, biomassa seca total e dose de máxima eficiência técnica. As mudas de paricá responderam positivamente ao uso do FLL, apresentando melhores padrões nos parâmetros de interesse em doses variando de 8,65 a 12,07 kg m-3 em relação ao controle sem FLL. Os custos de aquisição foram superiores quando comparados à adubação convencional, sendo necessária uma analise econômica e silvicultural para inferir sobre a viabilidade do seu uso na produção e implantação de plantios

Systemic sclerosis: state of the art on clinical practice guidelines

Systemic sclerosis (SSc) is an orphan disease characterised by autoimmunity, fibrosis of the skin and internal organs, and vasculopathy. SSc may be associated with high morbidity and mortality. In this narrative review we summarise the results of a systematic literature research, which was performed as part of the European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases project, aimed at evaluating existing clinical practice guidelines or recommendations. Only in the domains 'Vascular & Ulcers' (ie, non-pharmacological approach to digital ulcer), 'PAH' (ie, screening and treatment), 'Treatment' and 'Juveniles' (ie, evaluation of juveniles with Raynaud's phenomenon) evidence-based and consensus-based guidelines could be included. Hence there is a preponderance of unmet needs in SSc referring to the diagnosis and (non-)pharmacological treatment of several SSc-specific complications. Patients with SSc experience significant uncertainty concerning SSc-related taxonomy, management (both pharmacological and nonpharmacological) and education. Day-to-day impact of the disease (loss of self-esteem, fatigue, sexual dysfunction, and occupational, nutritional and relational problems) is underestimated and needs evaluation

Geographical heterogeneity of clinical and serological phenotypes of systemic sclerosis observed at tertiary referral centres. The experience of the Italian SIR-SPRING registry and review of the world literature

Introduction: Systemic sclerosis (SSc) is characterized by a complex etiopathogenesis encompassing both host genetic and environmental -infectious/toxic- factors responsible for altered fibrogenesis and diffuse microangiopathy. A wide spectrum of clinical phenotypes may be observed in patients' populations from different geographical areas. We investigated the prevalence of specific clinical and serological phenotypes in patients with definite SSc enrolled at tertiary referral centres in different Italian geographical macro-areas. The observed findings were compared with those reported in the world literature.Materials and methods: The clinical features of 1538 patients (161 M, 10.5%; mean age 59.8 +/- 26.9 yrs.; mean disease duration 8.9 +/- 7.7 yrs) with definite SSc recruited in 38 tertiary referral centres of the SPRING (Systemic sclerosis Progression INvestiGation Group) registry promoted by Italian Society of Rheumatology (SIR) were obtained and clustered according to Italian geographical macroareas.Results: Patients living in Southern Italy were characterized by more severe clinical and/or serological SSc phenotypes compared to those in Northern and Central Italy; namely, they show increased percentages of diffuse cutaneous SSc, digital ulcers, sicca syndrome, muscle involvement, arthritis, cardiopulmonary symptoms, interstitial lung involvement at HRCT, as well increased prevalence of serum anti-Scl70 autoantibodies. In the same SSc population immunusppressive drugs were frequently employed. The review of the literature underlined the geographical heterogeneity of SSc phenotypes, even if the observed findings are scarcely comparable due to the variability of methodological approaches.Conclusion: The phenotypical differences among SSc patients' subgroups from Italian macro-areas might be correlated to genetic/environmental co-factors, and possibly to a not equally distributed national network of information and healthcare facilities

Association of kidney disease measures with risk of renal function worsening in patients with type 1 diabetes

Background: Albuminuria has been classically considered a marker of kidney damage progression in diabetic patients and it is routinely assessed to monitor kidney function. However, the role of a mild GFR reduction on the development of stage 653 CKD has been less explored in type 1 diabetes mellitus (T1DM) patients. Aim of the present study was to evaluate the prognostic role of kidney disease measures, namely albuminuria and reduced GFR, on the development of stage 653 CKD in a large cohort of patients affected by T1DM. Methods: A total of 4284 patients affected by T1DM followed-up at 76 diabetes centers participating to the Italian Association of Clinical Diabetologists (Associazione Medici Diabetologi, AMD) initiative constitutes the study population. Urinary albumin excretion (ACR) and estimated GFR (eGFR) were retrieved and analyzed. The incidence of stage 653 CKD (eGFR < 60 mL/min/1.73 m2) or eGFR reduction > 30% from baseline was evaluated. Results: The mean estimated GFR was 98 \ub1 17 mL/min/1.73m2 and the proportion of patients with albuminuria was 15.3% (n = 654) at baseline. About 8% (n = 337) of patients developed one of the two renal endpoints during the 4-year follow-up period. Age, albuminuria (micro or macro) and baseline eGFR < 90 ml/min/m2 were independent risk factors for stage 653 CKD and renal function worsening. When compared to patients with eGFR > 90 ml/min/1.73m2 and normoalbuminuria, those with albuminuria at baseline had a 1.69 greater risk of reaching stage 3 CKD, while patients with mild eGFR reduction (i.e. eGFR between 90 and 60 mL/min/1.73 m2) show a 3.81 greater risk that rose to 8.24 for those patients with albuminuria and mild eGFR reduction at baseline. Conclusions: Albuminuria and eGFR reduction represent independent risk factors for incident stage 653 CKD in T1DM patients. The simultaneous occurrence of reduced eGFR and albuminuria have a synergistic effect on renal function worsening