Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

Análisis de los principios activos en Caléndula officinalis y Camellia sinensis

Tesis (Ingeniería Farmacéutica), Instituto Politécnico Nacional, UPIBI, 2009, 1 archivo PDF, (68 páginas). tesis.ipn.m

Identification, caractérisation fonctionnelle et histoire évolutive de gènes de virulence chez Mycobacterium tuberculosis

Mycobacterium tuberculosis (TB) tue environ 1,5 millions de personnes chaque année dans le monde. Une meilleure compréhension des mécanismes de virulence de TB pourrait permettre de proposer de nouvelles stratégies d'intervention, dont de nouveaux antibiotiques ou des candidats vaccins. La virulence mycobactérienne se manifeste d'abord par la capacité du bacille à parasiter les macrophages. Afin d'identifier des facteurs de virulence de M. tuberculosis impliqués dans ce processus, nous avons utilisé une banque de mutants de M. tuberculosis générée par la technique de STM (signature-transposon fagged mutagenesis; Camacho et al., 1999) que nous avons criblée dans des macrophages humains. Nous avons ainsi identifié 24 mutants atténués. En particulier nous avons caractérisé un opéron codant un transporteur ABC impliqué dans l'attachement et l'entrée de M. tuberculosis dans des cellules eukaryotes. Cet opéron est spécifique du complexe Tuberculosis et des espèces ancestrales de Mycobacterium prototuberculosis. Nous avons montré qu'il a été acquis latéralement par l'ancêtre du complexe M. tuberculosis à partir de v-protéobactéries de l'environnement.PARIS7-Bibliothèque centrale (751132105) / SudocSudocFranceF

Sistema integrado de gestión de Marketing de postulantes para un centro de estudios superior

Tesi