91 research outputs found
Phenylalanine Ammonia-Lyase in Tobacco (Molecular Cloning and Gene Expression during the Hypersensitive Reaction to Tobacco Mosaic Virus and the Response to a Fungal Elicitor)
α2,3-Sialyltransferase ST3Gal III Modulates Pancreatic Cancer Cell Motility and Adhesion In Vitro and Enhances Its Metastatic Potential In Vivo
Background: Cell surface sialylation is emerging as an important feature of cancer cell metastasis. Sialyltransferase expression has been reported to be altered in tumours and may account for the formation of sialylated tumour antigens. We have focused on the influence of alpha-2,3-sialyltransferase ST3Gal III in key steps of the pancreatic tumorigenic process. Methodology/Principal Findings: ST3Gal III overexpressing pancreatic adenocarcinoma cell lines Capan-1 and MDAPanc-28 were generated. They showed an increase of the tumour associated antigen sialyl-Lewis x. The transfectants ’ E-selectin binding capacity was proportional to cell surface sialyl-Lewis x levels. Cellular migration positively correlated with ST3Gal III and sialyl-Lewis x levels. Moreover, intrasplenic injection of the ST3Gal III transfected cells into athymic nude mice showed a decrease in survival and higher metastasis formation when compared to the mock cells. Conclusion: In summary, the overexpression of ST3Gal III in these pancreatic adenocarcinoma cell lines underlines the rol
Primeiro registro de galhas em panĂculas de cajazeira causadas por Clinodiplosis (Diptera: Cecidomyiidae) e avaliação de genĂłtipos no estado do PiauĂ
Occurrence and characterization of entomogen galls in plants from natural vegetation areas in DelfinĂłpolis, MG, Brazil
Life history of the gall-maker Eugeniamyia dispar Maia, Mendonça-Jr. & Romanowski, 1996 (Diptera, Cecidomyiidae)
Morphological and behavioural adaptations of the gall midge Lasioptera arundinis (Schiner) (Diptera, Cecidomyiidae) to collect and transport conidia of its fungal symbiont
Volume: 140Start Page: 59End Page: 6
Differences in attack of the spruce gall aphid Sacchiphantes abietis L. in a Norway spruce progeny trial
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