6 research outputs found
Formation of a molecular Bose-Einstein condensate and an entangled atomic gas by Feshbach resonance
Processes of association in an atomic Bose-Einstein condensate, and
dissociation of the resulting molecular condensate, due to Feshbach resonance
in a time-dependent magnetic field, are analyzed incorporating non-mean-field
quantum corrections and inelastic collisions. Calculations for the Na atomic
condensate demonstrate that there exist optimal conditions under which about
80% of the atomic population can be converted to a relatively long-lived
molecular condensate (with lifetimes of 10 ms and more). Entangled atoms in
two-mode squeezed states (with noise reduction of about 30 dB) may also be
formed by molecular dissociation. A gas of atoms in squeezed or entangled
states can have applications in quantum computing, communications, and
measurements.Comment: LaTeX, 5 pages with 4 figures, uses REVTeX
Differential impact of CD27 and 4-1BB costimulation on effector and memory CD8 T cell generation following peptide immunization
The factors that determine differentiation of naive CD8 T cells into memory cells are not well understood. A greater understanding of how memory cells are generated will inform of ways to improve vaccination strategies. In this study, we analyzed the CD8 T cell response elicited by two experimental vaccines comprising a peptide/protein Ag and an agonist that delivers a costimulatory signal via CD27 or 4-1BB. Both agonists increased expansion of Ag-specific CD8 T cells compared with Ag alone. However, their capacity to stimulate differentiation into effector and memory cells differed. CD27 agonists promoted increased expression of perforin and the generation of short-lived memory cells, whereas stimulation with 4-1BB agonists favored generation of stable memory. The memory-promoting effects of 4-1BB were independent of CD4 T cells and were the result of programing within the first 2 d of priming. Consistent with this conclusion, CD27 and 4-1BB–stimulated CD8 T cells expressed disparate amounts of IL-2, IFN-?, CD25, CD71, and Gp49b as early as 3 d after in vivo activation. In addition, memory CD8 T cells, generated through priming with CD27 agonists, proliferated more extensively than did 4-1BB–generated memory cells, but these cells failed to persist. These data demonstrate a previously unanticipated link between the rates of homeostatic proliferation and memory cell attrition. Our study highlights a role for these receptors in skewing CD8 T cell differentiation into effector and memory cells and provides an approach to optimize vaccines that elicit CD8 T cell responses
Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function
Functional Genomics of Systemic Disorder