Effects of diesel exhaust particle exposure on a murine model of asthma due to soybean

Exposure to soybean allergens has been linked to asthma outbreaks. Exposure to diesel exhaust particles (DEP) has been associated with an increase in the risk of asthma and asthma exacerbation; however, in both cases the underlying mechanisms remain poorly understood, as does the possible interaction between the two entities.To investigate how the combination of soybean allergens and DEP can affect the induction or exacerbation of asthma in a murine model.BALB/c mice received intranasal instillations of saline, 3 or 5 mg protein/ml soybean hull extract (SHE), or a combination of one of these three solutions with DEP. Airway hyperresponsiveness (AHR), pulmonary inflammation in bronchoalveolar lavage, total serum immunoglobulin E and histological studies were assessed.A 5 mg protein/ml SHE solution was able by itself to enhance AHR (p = 0.0033), increase eosinophilic inflammation (p = 0.0003), increase levels of IL-4, IL-5, IL-13, IL-17A, IL-17F and CCL20, and reduce levels of IFN-γ. The combination of 5 mg protein/ml SHE with DEP also produced an increase in AHR and eosinophilic inflammation, but presented a slightly different cytokine profile with higher levels of Th17-related cytokines. However, while the 3 mg protein/ml SHE solution did not induce asthma, co-exposure with DEP resulted in a markedly enhanced AHR (p = 0.002) and eosinophilic inflammation (p = 0.004), with increased levels of IL-5, IL-17F and CCL20 and decreased levels of IFN-γ.The combination of soybean allergens and DEP is capable of triggering an asthmatic response through a Th17-related mechanism when the soybean allergen concentration is too low to promote a response by itself. DEP monitoring may be a useful addition to allergen monitoring in order to prevent new asthma outbreaks

Elder Abuse and Mistreatment

This multidisciplinary volume assembles current findings on violent crime, behavioral, biological, and sociological perspectives on its causes, and effective methods of intervention and prevention. Noted experts across diverse fields apply a behavioral criminology lens to examine crimes committed by minors, extremely violent offenses, sexual offending, violence in families, violence in high-risk settings, and crimes of recent and emerging interest. The work of mental health practitioners and researchers is shown informing law enforcement response to crime in interrogation, investigative analysis, hostage negotiations, and other core strategies. In addition, chapters pay special attention to criminal activities that violate traditional geographic boundaries, from cyberstalking to sex trafficking to international terrorism. Among the topics in the Handbook: Dyadic conceptualization, measurement, and analysis of family violence. School bullying and cyberbullying: prevalence, characteristics, outcomes, and prevention. A cultural and psychological perspective on mass murder. Young people displaying problematic sexual behavior: the research and their words. Child physical abuse and neglect. Criminal interviewing and interrogation in serious crime investigations. Violence in correctional settings. Foundations of threat assessment and management. The Handbook of Behavioral Criminology is a meticulous resource for researchers in criminology, psychology, sociology, and related fields. It also informs developers of crime prevention programs and practitioners assessing and intervening with criminal clients and in correctional facilities.https://nsuworks.nova.edu/cps_facbooks/1556/thumbnail.jp