the interplay of rationality and identity in a mathematical group work

This contribution originates from a joint work aimed at networking theoretical tools and employ them to better understand teaching and learning episodes, with a special focus on mathematical group work. In a socio-cultural perspective, two theoretical lenses are combined: the construct of rational behavior, initially developed by Habermas and adapted in mathematics education, and that of identity. In this paper we propose a general description of our approach and present the main findings emerged after investigations in grade 6 (group work on negative numbers) and grade 4 (arithmetics problem solving). The networked analysis sheds light into mathematical group works: the students' mathematical identities turn into prevailing dimensions of rational behavior and the interplay of dimensions of rationality affects the participation into the group activity. Moreover, the teacher is shown to have a role in students' identifying process, affecting indirectly the students' participation

Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus

Systemic Lupus Erythematosus (SLE, OMIM 152700) is an autoimmune disease characterized by self-reactive antibodies resulting in systemic inflammation and organ failure. TNFAIP3, encoding the ubiquitin-modifying enzyme A20, is an established susceptibility locus for SLE. By fine mapping and genomic resequencing in ethnically diverse populations we fully characterized the TNFAIP3 risk haplotype and isolated a novel TT>A polymorphic dinucleotide associated with SLE in subjects of European (P = 1.58 × 10(−8); odds ratio (OR) = 1.70) and Korean (P = 8.33 × 10(−10); OR = 2.54) ancestry. This variant, located in a region of high conservation and regulatory potential, bound a nuclear protein complex comprised of NF-κB subunits with reduced avidity. Furthermore, compared with the non-risk haplotype, the haplotype carrying this variant resulted in reduced TNFAIP3 mRNA and A20 protein expression. These results establish this TT>A variant as the most likely functional polymorphism responsible for the association between TNFAIP3 and SLE

The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project

The PREDICTS project-Projecting Responses of Ecological Diversity In Changing Terrestrial Systems (www.predicts.org.uk)-has collated from published studies a large, reasonably representative database of comparable samples of biodiversity from multiple sites that differ in the nature or intensity of human impacts relating to land use. We have used this evidence base to develop global and regional statistical models of how local biodiversity responds to these measures. We describe and make freely available this 2016 release of the database, containing more than 3.2 million records sampled at over 26,000 locations and representing over 47,000 species. We outline how the database can help in answering a range of questions in ecology and conservation biology. To our knowledge, this is the largest and most geographically and taxonomically representative database of spatial comparisons of biodiversity that has been collated to date; it will be useful to researchers and international efforts wishing to model and understand the global status of biodiversity