The Challenge Non-Typhoidal Salmonella (CHANTS) Consortium: Development of a non-typhoidal Salmonella controlled human infection model: Report from a consultation group workshop, 05 July 2022, London, UK [version 2; peer review: 2 approved]

Invasive non-typhoidal Salmonella disease (iNTS) is a major cause of morbidity and mortality globally, particularly as a cause of bloodstream infection in children and immunocompromised adults in sub-Saharan Africa. Vaccines to prevent non-typhoidal Salmonella (NTS) would represent a valuable public health tool in this setting to avert cases and prevent expansion of antimicrobial resistance. Several NTS and combination typhoidal-NTS vaccine candidates are in early-stage development, although the pathway to licensure is unclear due to challenges in conducting large phase III field trials. Controlled human infection models (CHIM) present an opportunity to accelerate vaccine development for a range of enteric pathogens. Several recent typhoidal Salmonella CHIMs have been conducted safely and have played pivotal roles in progressing vaccine candidates to pre-qualification and licensure. The Challenge Non-Typhoidal Salmonella (CHANTS) consortium has been formed with funding from the Wellcome Trust, to deliver the first NTS CHIM, which can act as a platform for future vaccine evaluation. This paper reports the conclusions of a consultation group workshop convened with key stakeholders. The aims of this meeting were to: (1) define the rationale for an NTS CHIM (2) map the NTS vaccine pipeline (3) refine study design and (4) establish potential future use cases

Deepening of the anterior chamber may impair the aqueous outflow system in guinea pigs

This is a 2021 ARVO Annual Meeting abstract.202205 bcfcMetadata onlyRGCOthersHenry G. Leong Endowed Professorship in Elderly Vision HealthPublishe

Additive effects of narrowband light and optical defocus on chick eye growth and refraction

202304 bcwwVersion of RecordRGCOthersThis work was supported by the PolyU internal grant (Grant No. ZVS5, BD90); Research Centre for SHARP Vision (Grant No. P0039545); General Research Fund (Grant No. P0005641), Research Impact Fund (Grant No. P0013939), the Government of the Hong Kong Special Administrative Region (InnoHK) and Henry G. Leong Endowed Professorship in Elderly Vision Health (8-847)Publishe