15 research outputs found
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Disseminated sarcoidosis with testicular involvement: A case report and literature review
Sarcoidosis is a multisystem inflammatory disease of unknown etiology that predominantly affects the lungs and intrathoracic lymph nodes. Testicular sarcoidosis is a rare presentation of this disease. We review the case of a patient with stage 2 sarcoidosis with bilateral intrascrotal involvement along with classic pulmonary, lymphoid, and dermatological manifestations. We provide a literature review of testicular sarcoidosis and discuss the diagnostic challenges and the management of intrascrotal mass in setting of disseminated sarcoidosis. Copyright © 2014 by Lippincott Williams & Wilkins
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Disseminated sarcoidosis with testicular involvement: A case report and literature review
Sarcoidosis is a multisystem inflammatory disease of unknown etiology that predominantly affects the lungs and intrathoracic lymph nodes. Testicular sarcoidosis is a rare presentation of this disease. We review the case of a patient with stage 2 sarcoidosis with bilateral intrascrotal involvement along with classic pulmonary, lymphoid, and dermatological manifestations. We provide a literature review of testicular sarcoidosis and discuss the diagnostic challenges and the management of intrascrotal mass in setting of disseminated sarcoidosis. Copyright © 2014 by Lippincott Williams & Wilkins
Formulation development, optimization, and in vitro assessment of thermoresponsive ophthalmic pluronic F127-chitosan in situ
Sucrose ester-based biocompatible microemulsions as vehicles for aceclofenac as a model drug: formulation approach using D-optimal mixture design
Density dependence across multiple life stages in a temperate old-growth forest of northeast China
A qualitative study about the gendered experiences of motherhood and perinatal mortality in mountain villages of Nepal: implications for improving perinatal survival
Accelerators/decelerators of achieving universal access to sexual and reproductive health services: a case study of Iranian health system
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The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens.
BackgroundThe Critical Assessment of Functional Annotation (CAFA) is an ongoing, global, community-driven effort to evaluate and improve the computational annotation of protein function.ResultsHere, we report on the results of the third CAFA challenge, CAFA3, that featured an expanded analysis over the previous CAFA rounds, both in terms of volume of data analyzed and the types of analysis performed. In a novel and major new development, computational predictions and assessment goals drove some of the experimental assays, resulting in new functional annotations for more than 1000 genes. Specifically, we performed experimental whole-genome mutation screening in Candida albicans and Pseudomonas aureginosa genomes, which provided us with genome-wide experimental data for genes associated with biofilm formation and motility. We further performed targeted assays on selected genes in Drosophila melanogaster, which we suspected of being involved in long-term memory.ConclusionWe conclude that while predictions of the molecular function and biological process annotations have slightly improved over time, those of the cellular component have not. Term-centric prediction of experimental annotations remains equally challenging; although the performance of the top methods is significantly better than the expectations set by baseline methods in C. albicans and D. melanogaster, it leaves considerable room and need for improvement. Finally, we report that the CAFA community now involves a broad range of participants with expertise in bioinformatics, biological experimentation, biocuration, and bio-ontologies, working together to improve functional annotation, computational function prediction, and our ability to manage big data in the era of large experimental screens