Depression is related to an absence of optimistically biased belief updating about future life events

BACKGROUND: When challenged with information about the future, healthy participants show an optimistically biased updating pattern, taking desirable information more into account than undesirable information. However, it is unknown how patients suffering from major depressive disorder (MDD), who express pervasive pessimistic beliefs, update their beliefs when receiving information about their future. Here we tested whether an optimistically biased information processing pattern found in healthy individuals is absent in MDD patients. Method MDD patients (n = 18; 13 medicated; eight with co-morbid anxiety disorder) and healthy controls (n = 19) estimated their personal probability of experiencing 70 adverse life events. After each estimate participants were presented with the average probability of the event occurring to a person living in the same sociocultural environment. This information could be desirable (i.e. average probability better than expected) or undesirable (i.e. average probability worse than expected). To assess how desirable versus undesirable information influenced beliefs, participants estimated their personal probability of experiencing the 70 events a second time. RESULTS: Healthy controls showed an optimistic bias in updating, that is they changed their beliefs more toward desirable versus undesirable information. Overall, this optimistic bias was absent in MDD patients. Symptom severity correlated with biased updating: more severely depressed individuals showed a more pessimistic updating pattern. Furthermore, MDD patients estimated the probability of experiencing adverse life events as higher than healthy controls. CONCLUSIONS: Our findings raise the intriguing possibility that optimistically biased updating of expectations about one's personal future is associated with mental health

Novel Environmental Features for Robust Multisensor Navigation

Many navigation techniques have now become so reliant on GNSS that there is no back up when there is limited or no signal reception. If there is interference, intentional or otherwise, with the signal, navigation could be lost or become misleading [1]. Other navigation techniques harness different technologies such as Wi-Fi [2], eLoran and inertial navigation. However, each of these techniques has its own limitations, such as coverage, degradation in urban areas or solution drift [3]. Therefore there is a need for new navigation and positioning techniques that may be integrated with GNSS to increase the reliability of the system as a whole. This paper presents the results of a feasibility study to identify a set of novel environmental features that could be used for navigation in the temporary absence of GNSS or degradation of the signal. By measuring these features during times of GNSS availability a map can be produced. This can be referred to during times of limited reception, a principle already used for some Wi-Fi positioning techniques [2]. Therefore a “measurable” can be defined as a feature either man-made or natural that is spatially distinct and has limited temporal variation. Possibilities considered include magnetic anomalies [4], light intensity and road signs. Firstly, a brainstorming exercise and a literature study were conducted to generate a list of possible environmental features that was assessed for the viability of each candidate. The features were ranked according to three criteria: practicality, precision and coverage. The definition of practicality for each measurable was that a suitable detector must be installable on a road vehicle, particularly an emergency vehicle, at a reasonable cost with minimal alterations to the vehicle. Precision was defined in terms of the spatial variation of the environmental feature and thus the accuracy with which position information might be derived from it. Coverage was assessed in terms of the availability of the feature over a range of different environments. Continuous coverage is not required because the new measurables may be used in combination and integrated with dead reckoning techniques, such as odometry and inertial navigation [3]. The outcome of the viability study was used to determine which features are to be experimentally tested. Magnetic anomalies, road texture and a dozen other environmental features were found to be worth investigation. Features which were discounted include wind speed and pulsars [5]. The initial experiment was carried out on foot in Central London. The same tests were repeated on two separate days, with a closed loop circuit walked three times on each occasion. This experiment used an Inertial Measurement Unit (IMU), comprising accelerometer and gyro triads, together with a barometer, three-axis magnetometer and GNSS receiver. The experiment was also recorded using a camcorder from the point of view of a pedestrian, enabling visual and audio features of the environment to be assessed. Magnetic anomalies were found to be a promising source of position information. Peaks in the magnetometer data were observed on all rounds at approximately the same positions. There were also similarities seen in the temperature profiles after correcting for the temporal variation of the background temperature. Another potential source of position information was found to be text-based signs. It is relatively simple to extract text from camera images and it is easily stored in a feature database. However, methods of dealing with identically-worded signs in close proximity will need to be developed. Sound levels were analysed in 10s intervals for the mean, minimum and maximum sound volume. There was no clear correlation observed between the different rounds of the experiment. Due to the pedestrian experimental results sound levels of the surroundings will not be used in further experimentation. An alternative area of enquiry for using sound (in the vehicular experiments) is using microphones to indirectly measure road texture based on the noise from the wheel contact with the road [6]. The paper will also present results of road vehicle experiments. Multiple circuits of the same routes will be compared. Different environments will be assessed including rural, dual carriageways, suburban and urban roads. Sensors to be used include the IMU and 3-axis magnetometer from the pedestrian experiment, a barometer, gas sensors, a microphone, an axle-mounted accelerometer, an ambient light sensor and a thermometer. These will be placed either on, inside or under the vehicle as determined by the individual needs of the sensors. The results will be used to determine which of these sensors could be potentially used for a multisensor integrated navigation system and also the environments in which they work optimally. Using the results of the three feasibility study phases (literature review, pedestrian and road experiment) the next project stage will be to produce a demonstration system that uses the most feasible features of the environment and creates a map database during times GNSS is present. This database will then be used for navigation in times of need. In the long term, it is envisaged that this technique will be implemented cooperatively, with a batch of vehicles collecting feature data and contributing it to a common shared database. / References [1] Thomas, M., et al., Global Navigation Space Systems: Reliance and Vulnerabilities, London, UK: Royal Academy of Engineering, 2011. [2] Jones, K., L. Liu, and F. Alizadeh-Shabdiz, “Improving Wireless Positioning with Look-ahead Map-Matching,” Proc. MobiQuitous 2007, Phildaelphia, PA, February 2008, pp. 1-8. [3] Groves, P.D., Principles of GNSS, Inertial, and Multisensor Intergrated Navigation Systems, Second Edition, Artech House, 2013. [4] Judd, T., and T. Vu, “Use of a New Pedometric Dead Reckoning Module in GPS Denied Environments,” Proc. IEEE/ION PLANS, Monterey, CA, May 2008, pp. 120?128. [5] Walter, D. J., "Feasibility study of novel environmental feature mapping to bridge GNSS outage," Young Navigator Conference, London, 2012. [6] Mircea, M., et al., “Strategic mapping of the ambient noise produced by road traffic, accordingly to European regulations,” Proc. IEEE International Conference on Automation, Quality and Testing, Robotics, Cluj Napoca, Romania, May 2008

Constraining the nature of two Lyα emitters detected by ALMA at z = 4.7

We report optical VLT FORS2 spectroscopy of the two Ly-alpha emitters (LAEs) companions to the quasi-stellar object (QSO) - sub-millimetre galaxy (SMG) system BRI1202-0725 at z = 4.7, which have recently been detected in the [CII]158um line by the Atacama Large Millimetre/Sub-millimetre Array (ALMA). We detect Ly-alpha emission from both sources and so confirm that these Ly-alpha emitter candidates are physically associated with the BRI1202- 0725 system. We also report the lack of detection of any high ionisation emission lines (N V, Si IV, C IV and He II) and find that these systems are likely not photoionised by the quasar, leaving in situ star formation as the main powering source of these LAEs. We also find that both LAEs have Ly-alpha emission much broader (1300 km/s) than the [CII] emission and broader than most LAEs. In addition, both LAEs have roughly symmetric Ly-alpha profiles implying that both systems are within the HII sphere produced by the quasar. This is the first time that the proximity zone of a quasar is probed by exploiting nearby Ly-alpha emitters. We discuss the observational properties of these galaxies in the context of recent galaxy formation models.This work was co-funded under the Marie Curie Actions of the European Commission (FP7-COFUND).This is the final published version, which originally appeared in MNRAS and is available at http://mnras.oxfordjournals.org/content/439/2/2096

Report on the Standardization Project ``Formal Methods in Conformance Testing''

This paper presents the latest developments in the “Formal Methods in Conformance Testing” (FMCT) project of ISO and ITU–T. The project has been initiated to study the role of formal description techniques in the conformance testing process. The goal is to develop a standard that defines the meaning of conformance in the context of formal description techniques. We give an account of the current status of FMCT in the standardization process as well as an overview of the technical status of the proposed standard. Moreover, we indicate some of its strong and weak points, and we give some directions for future work on FMCT

An ongoing case-control study to evaluate the NHS Bowel Cancer Screening Programme

© 2014 Massat et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated

Environmental life cycle assessment of wire arc additively manufactured steel structural components

Wire arc additive manufacturing (WAAM) enables the production of structural components with topologically optimised geometries thus leading to significant self-weight reductions for a given load-carrying capacity. A common question arises regarding the environmental performance of WAAM structural components in comparison with conventional steel structural components. Thus, a comparative cradle-to-gate life cycle assessment has been conducted where the environmental impact of producing a topologically optimised WAAM steel beam is compared with that of producing a conventional hot-rolled steel I-beam. The beams are 2 m long, simply-supported and loaded vertically at midspan. The impact of using either carbon steel or stainless steel is investigated. The results demonstrate that the carbon steel and stainless steel WAAM beams have 7% and 24%, respectively, lower climate change impact than the corresponding I-beams. It is concluded that WAAM can lead to lower CO2-eq. emissions than conventional hot-rolling, provided that mass reductions of the order of 50% (which are readily attainable) can be achieved by employing WAAM in conjunction with, for instance, topology optimisation. Furthermore, it is shown that the shielding gas contributes greatly to the environmental impact of WAAM, and that, by using higher deposition rates or by utilising renewable energy sources, the impact of WAAM can be reduced by more than 30%

Complex circular subsidence structures in tephra deposited on large blocks of ice: Varða tuff cone, Öræfajökull, Iceland

Several broadly circular structures up to 16 m in diameter, into which higher strata have sagged and locally collapsed, are present in a tephra outcrop on southwest Öræfajökull, southern Iceland. The tephra was sourced in a nearby basaltic tuff cone at Varða. The structures have not previously been described in tuff cones, and they probably formed by the melting out of large buried blocks of ice emplaced during a preceding jökulhlaup that may have been triggered by a subglacial eruption within the Öræfajökull ice cap. They are named ice-melt subsidence structures, and they are analogous to kettle holes that are commonly found in proglacial sandurs and some lahars sourced in ice-clad volcanoes. The internal structure is better exposed in the Varða examples because of an absence of fluvial infilling and reworking, and erosion of the outcrop to reveal the deeper geometry. The ice-melt subsidence structures at Varða are a proxy for buried ice. They are the only known evidence for a subglacial eruption and associated jökulhlaup that created the ice blocks. The recognition of such structures elsewhere will be useful in reconstructing more complete regional volcanic histories as well as for identifying ice-proximal settings during palaeoenvironmental investigations

Early star-forming galaxies and the reionization of the Universe

Star forming galaxies represent a valuable tracer of cosmic history. Recent observational progress with Hubble Space Telescope has led to the discovery and study of the earliest-known galaxies corresponding to a period when the Universe was only ~800 million years old. Intense ultraviolet radiation from these early galaxies probably induced a major event in cosmic history: the reionization of intergalactic hydrogen. New techniques are being developed to understand the properties of these most distant galaxies and determine their influence on the evolution of the universe.Comment: Review article appearing in Nature. This posting reflects a submitted version of the review formatted by the authors, in accordance with Nature publication policies. For the official, published version of the review, please see http://www.nature.com/nature/archive/index.htm