32 research outputs found
Assessment of a Poisson animal model for embryo yield in a simulated multiple ovulation-embryo transfer scheme
Marginal maximum likelihood estimation of variance components in Poisson mixed models using Laplacian integration
International audienc
Marginal maximum likelihood estimation of variance components in Poisson mixed models using Laplacian integration
Assessment of a Poisson animal model for embryo yield in a simulated multiple ovulation-embryo transfer scheme
International audienc
MicroarrayDesigner: an online search tool and repository for near-optimal microarray experimental designs
<p>Abstract</p> <p>Background</p> <p>Dual-channel microarray experiments are commonly employed for inference of differential gene expressions across varying organisms and experimental conditions. The design of dual-channel microarray experiments that can help minimize the errors in the resulting inferences has recently received increasing attention. However, a general and scalable search tool and a corresponding database of optimal designs were still missing.</p> <p>Description</p> <p>An efficient and scalable search method for finding near-optimal dual-channel microarray designs, based on a greedy hill-climbing optimization strategy, has been developed. It is empirically shown that this method can successfully and efficiently find near-optimal designs. Additionally, an improved interwoven loop design construction algorithm has been developed to provide an easily computable general class of near-optimal designs. Finally, in order to make the best results readily available to biologists, a continuously evolving catalog of near-optimal designs is provided.</p> <p>Conclusion</p> <p>A new search algorithm and database for near-optimal microarray designs have been developed. The search tool and the database are accessible via the World Wide Web at <url>http://db.cse.ohio-state.edu/MicroarrayDesigner</url>. Source code and binary distributions are available for academic use upon request.</p