3,629 research outputs found
Transmission tree of the highly pathogenic avian influenza (H5N1) epidemic in Israel, 2015
The transmission tree of the Israeli 2015 epidemic of highly pathogenic avian influenza (H5N1) was modelled by combining the spatio-temporal distribution of the outbreaks and the genetic distance between virus isolates. The most likely successions of transmission events were determined and transmission parameters were estimated. It was found that the median infectious pressure exerted at 1 km was 1.59 times (95% CI 1.04, 6.01) and 3.54 times (95% CI 1.09, 131.75) higher than that exerted at 2 and 5 km, respectively, and that three farms were responsible for all seven transmission events. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13567-016-0393-2) contains supplementary material, which is available to authorized users
SUSY Stops at a Bump
We discuss collider signatures of the "natural supersymmetry" scenario with
baryon-number violating R-parity violation. We argue that this is one of the
few remaining viable incarnations of weak scale supersymmetry consistent with
full electroweak naturalness. We show that this intriguing and challenging
scenario contains distinctive LHC signals, resonances of hard jets in
conjunction with relatively soft leptons and missing energy, which are easily
overlooked by existing LHC searches. We propose novel strategies for
distinguishing these signals above background, and estimate their potential
reach at the 8 TeV LHC. We show that other multi-lepton signals of this
scenario can be seen by currently existing searches with increased statistics,
but these opportunities are more spectrum-dependent.Comment: 23 pages, 7 figures, 3 tables. V2: spectrum discussion corrected,
most of the changes are in Sec. 2. Benchmarks, analysis and conclusions
unchanged. References adde
Effects of an ACTH 4-9 related peptide upon intracranial self stimulation and general activity in the rat
Adult male Sprague-Dawley rats were stereotactically implanted with electrodes within the anterior medial forebrain bundle: The rats were trained to respond for intracranial self-stimulation (ICS) and treated with control solution or varying doses of an ACTH 4-9 related synthetic peptide (Org 2766; H-Met(O 2 )-Glu-His-Phe- d -Lys-Phe-OH). The drug affected ICS as measured in overnight response records, with the highest dose reliably increasing the amount of responding. In a second experiment rats were similarly treated and general activity was assessed. No remarkable changes in activity were present at any tested dose. The findings corroborate previous reports suggesting ACTH-related peptides may be active in a variety of motivated tasks, but less active with respect to general activity.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46417/1/213_2004_Article_BF00433254.pd
British Valued Life Activities Scale [British VLAs]
Background
The Valued Life Activities Scale (VLAs) measures difficulty in daily activities and social participation. With various versions involving a different number of items, we have linguistically and culturally adopted the full VLAs (33-items) and psychometrically tested it in adults with rheumatic and musculoskeletal diseases in the United Kingdom.
Methods
Participants with Rheumatoid Arthritis, Ankylosing Spondylitis, Chronic Pain/ Fibromyalgia, Chronic Hand/ Upper Limb Conditions, Osteoarthritis, Systemic Lupus, Systemic Sclerosis and Primary Sjogren’s Syndrome were recruited from out-patient clinics in National Health Service Hospitals, General Practice and patient organisations in the UK. Phase1 involved linguistic and cultural adaptation: forward translation to British English; synthesis; expert panel review and cognitive debriefing interviews. In Phase2 participants completed postal questionnaires to assess internal construct validity using (i) Confirmatory Factor Analysis (CFA) (ii) Mokken scaling and (iii) Rasch model.
Results
Responders (n = 1544) had mean age of 59 years (SD13.3) and 77.2% women. A CFA failed to support a total score from the 33-items (Chi Square 3552:df 464: p < 0.0001). Mokken scaling indicated a strong non-parametric association between items. Fit to the Rasch model indicated that the VLAs was characterised by multidimensionality and item misfit, which may have been influenced by clusters of residual item correlations. An item banking approach resolved a 25-item calibrated set whose application could accommodate the ‘does not apply to me’ response option.
Conclusions
The UK version of the VLAs failed to satisfy classical and modern psychometric standards for complete item sets. However, as the scale is not usually applied in complete format, an item bank approach calibrated 25 items with fit to the Rasch model. Suitable Computer Adaptive Testing (CAT) software could implement the item set, giving patients the choice of whether an item applies to them, or not
On the Gold Standard for Security of Universal Steganography
While symmetric-key steganography is quite well understood both in the
information-theoretic and in the computational setting, many fundamental
questions about its public-key counterpart resist persistent attempts to solve
them. The computational model for public-key steganography was proposed by von
Ahn and Hopper in EUROCRYPT 2004. At TCC 2005, Backes and Cachin gave the first
universal public-key stegosystem - i.e. one that works on all channels -
achieving security against replayable chosen-covertext attacks (SS-RCCA) and
asked whether security against non-replayable chosen-covertext attacks (SS-CCA)
is achievable. Later, Hopper (ICALP 2005) provided such a stegosystem for every
efficiently sampleable channel, but did not achieve universality. He posed the
question whether universality and SS-CCA-security can be achieved
simultaneously. No progress on this question has been achieved since more than
a decade. In our work we solve Hopper's problem in a somehow complete manner:
As our main positive result we design an SS-CCA-secure stegosystem that works
for every memoryless channel. On the other hand, we prove that this result is
the best possible in the context of universal steganography. We provide a
family of 0-memoryless channels - where the already sent documents have only
marginal influence on the current distribution - and prove that no
SS-CCA-secure steganography for this family exists in the standard
non-look-ahead model.Comment: EUROCRYPT 2018, llncs styl
The optical counterpart to gamma-ray burst GRB970228 observed using the Hubble Space Telescope
Although more than 2,000 astronomical gamma-ray bursts (GRBs) have been
detected, and numerous models proposed to explain their occurrence, they have
remained enigmatic owing to the lack of an obvious counterpart at other
wavelengths. The recent ground-based detection of a transient source in the
vicinity of GRB 970228 may therefore have provided a breakthrough. The optical
counterpart appears to be embedded in an extended source which, if a galaxy as
has been suggested, would lend weight to those models that place GRBs at
cosmological distances. Here we report the observations using the Hubble Space
Telescope of the transient counterpart and extended source 26 and 39 days after
the initial gamma-ray outburst. We find that the counterpart has faded since
the initial detection (and continues to fade), but the extended source exhibits
no significant change in brightness between the two dates of observations
reported here. The size and apparent constancy between the two epochs of HST
observations imply that it is extragalactic, but its faintness makes a
definitive statement about its nature difficult. Nevertheless, the decay
profile of the transient source is consistent with a popular impulsive-fireball
model, which assumes a merger between two neutron stars in a distant galaxy.Comment: 11 pages + 2 figures. To appear in Nature (29 May 1997 issue
Labels direct infants’ attention to commonalities during novel category learning
Recent studies have provided evidence that labeling can influence the outcome of infants’ visual categorization. However, what exactly happens during learning remains unclear. Using eye-tracking, we examined infants’ attention to object parts during learning. Our analysis of looking behaviors during learning provide insights going beyond merely observing the learning outcome. Both labeling and non-labeling phrases facilitated category formation in 12-month-olds but not 8-month-olds (Experiment 1). Non-linguistic sounds did not produce this effect (Experiment 2). Detailed analyses of infants’ looking patterns during learning revealed that only infants who heard labels exhibited a rapid focus on the object part successive exemplars had in common. Although other linguistic stimuli may also be beneficial for learning, it is therefore concluded that labels have a unique impact on categorization
The World Hip Trauma Evaluation Study 3 HEMIARTHROPLASTY EVALUATION BY MULTICENTRE INVESTIGATION - WHiTE 3: HEMI - AN ABRIDGED PROTOCOL
Approximately half of all hip fractures are displaced intracapsular fractures. The standard treatment for these fractures is either hemiarthroplasty or total hip arthroplasty. The recent National Institute for Health and Care Excellence (NICE) guidance on hip fracture management recommends the use of 'proven' cemented stem arthroplasty with an Orthopaedic Device Evaluation Panel (ODEP) rating of at least 3B (97% survival at three years). The Thompsons prosthesis is currently lacking an ODEP rating despite over 50 years of clinical use, likely due to the paucity of implant survival data. Nationally, adherence to these guidelines is varied as there is debate as to which prosthesis optimises patient outcomes.This study design is a multi-centre, multi-surgeon, parallel, two arm, standard-of-care pragmatic randomised controlled trial. It will be embedded within the WHiTE Comprehensive Cohort Study (ISRCTN63982700). The main analysis is a two-way equivalence comparison between Hemi-Thompson and Hemi-Exeter polished taper with Unitrax head. Secondary outcomes will include radiological leg length discrepancy measured as per Bidwai and Willett, mortality, re-operation rate and indication for re-operation, length of index hospital stay and revision at four months. This study will be supplemented by the NHFD (National Hip Fracture Database) dataset.Evidence on the optimum choice of prosthesis for hemiarthroplasty of the hip is lacking. National guidance is currently based on expert opinion rather than empirical evidence. The incidence of hip fracture is likely to continue to increase and providing high quality evidence on the optimumCite this article: A. L. Sims. The World Hip Trauma Evaluation Study 3: Hemiarthroplasty Evaluation by Multicentre Investigation - WHITE 3: HEMI - An Abridged Protocol. Bone Joint Res 2016;5:18-25. doi: 10.1302/2046-3758.51.2000473
Patients' preferences for adjuvant endocrine therapy in early breast cancer: what makes it worthwhile?
Adjuvant endocrine therapy improves recurrence and survival rates, but has side effects and is inconvenient. The aim of this study was to determine the preferences of premenopausal women who had adjuvant endocrine therapy in a randomised trial. In all, 85 (or eighty-five) women completed semistructured interviews 6–30 months after finishing adjuvant endocrine therapy. Hypothetical scenarios based on known potential survival times (5 or 15 years) and rates (60% or 80% at 5 years) without adjuvant endocrine therapy were used to determine the smallest gains women judged necessary to make their adjuvant endocrine therapy worthwhile. Although a third of the women considered gains of 1% in survival rates or 6 months in survival times sufficient to make their adjuvant endocrine therapy worthwhile, more than half the women required gains of at least 5% in survival rates or 3 years in survival time as necessary to make adjuvant endocrine therapy worthwhile. Larger benefits were required by women who had longer treatment, worse side effects, and by those who were treated with goserelin alone. The route of administration (tablet vs injection) did not affect preferences and some women judged small benefits sufficient to make their adjuvant endocrine therapy worthwhile, but many women required larger benefits than their counterparts in similar studies of preferences for adjuvant chemotherapy
Enduring Legacy? Charles Tilly and Durable Inequality
This article assesses Charles Tilly’s Durable Inequality and traces its influence. In writing Durable Inequality, Tilly sought to shift the research agenda of stratification scholars. But the book’s initial impact was disappointing. In recent years, however, its influence has grown, suggesting a more enduring legacy
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