509 research outputs found
The startup cartography project: measuring and mapping entrepreneurial ecosystems
This paper presents the Startup Cartography Project, which offers a new set of entrepreneurial ecosystem statistics for the United States from 1988-2016. The SCP combines state-level business registration records with a predictive analytics approach to estimate the probability of “extreme” growth (IPO or high-value acquisition) at or near the time of founding for all newlyregistered firms in a given year. The results indicate the ability of predictive analytics to identify high-potential start-ups at founding (using a variety of different approaches and measures). The SCP then leverages estimates of entrepreneurial quality to develop four entrepreneurial ecosystem statistics, including the rate of start-up formation, average entrepreneurial quality, the quality-adjusted quantity of entrepreneurship, and entrepreneurial ecosystem performance over time. These statistics offer sharp insight into patterns of regional entrepreneurship, their correlation with regional economic growth and the evolution of entrepreneurial ecosystems over time. The SCP includes both a public-access dataset at the state, MSA, county, and zip code level, as well as an interactive map, the U.S. Startup Map, that allows academic and policy users to assess entrepreneurial ecosystems at an arbitrary level of granularity (from the level of states down to individual street addresses).https://www.startupcartography.com/researc
On the Gold Standard for Security of Universal Steganography
While symmetric-key steganography is quite well understood both in the
information-theoretic and in the computational setting, many fundamental
questions about its public-key counterpart resist persistent attempts to solve
them. The computational model for public-key steganography was proposed by von
Ahn and Hopper in EUROCRYPT 2004. At TCC 2005, Backes and Cachin gave the first
universal public-key stegosystem - i.e. one that works on all channels -
achieving security against replayable chosen-covertext attacks (SS-RCCA) and
asked whether security against non-replayable chosen-covertext attacks (SS-CCA)
is achievable. Later, Hopper (ICALP 2005) provided such a stegosystem for every
efficiently sampleable channel, but did not achieve universality. He posed the
question whether universality and SS-CCA-security can be achieved
simultaneously. No progress on this question has been achieved since more than
a decade. In our work we solve Hopper's problem in a somehow complete manner:
As our main positive result we design an SS-CCA-secure stegosystem that works
for every memoryless channel. On the other hand, we prove that this result is
the best possible in the context of universal steganography. We provide a
family of 0-memoryless channels - where the already sent documents have only
marginal influence on the current distribution - and prove that no
SS-CCA-secure steganography for this family exists in the standard
non-look-ahead model.Comment: EUROCRYPT 2018, llncs styl
Publisher Correction: Graphene overcoats for ultra-high storage density magnetic media.
Publisher Correction: Graphene overcoats for ultra-high storage density magnetic media
Direct photon production with effective field theory
The production of hard photons in hadronic collisions is studied using
Soft-Collinear Effective Theory (SCET). This is the first application of SCET
to a physical, observable cross section involving energetic partons in more
than two directions. A factorization formula is derived which involves a
non-trivial interplay of the angular dependence in the hard and soft functions,
both quark and gluon jet functions, and multiple partonic channels. The
relevant hard, jet and soft functions are computed to one loop and their
anomalous dimensions are determined to three loops. The final resummed
inclusive direct photon distribution is valid to next-to-next-to-leading
logarithmic order (NNLL), one order beyond previous work. The result is
improved by including non-logarithmic terms and photon isolation cuts through
matching, and compared to Tevatron data and to fixed order results at the
Tevatron and the LHC. The resummed cross section has a significantly smaller
theoretical uncertainty than the next-to-leading fixed-order result,
particularly at high transverse momentum.Comment: 42 pages, 9 figures; v2: references added, minor changes; v3: typos;
v4: typos, corrections in (16), (47), (72
Dynamics and transport near quantum-critical points
The physics of non-zero temperature dynamics and transport near
quantum-critical points is discussed by a detailed study of the O(N)-symmetric,
relativistic, quantum field theory of a N-component scalar field in spatial
dimensions. A great deal of insight is gained from a simple, exact solution of
the long-time dynamics for the N=1 d=1 case: this model describes the critical
point of the Ising chain in a transverse field, and the dynamics in all the
distinct, limiting, physical regions of its finite temperature phase diagram is
obtained. The N=3, d=1 model describes insulating, gapped, spin chain
compounds: the exact, low temperature value of the spin diffusivity is
computed, and compared with NMR experiments. The N=3, d=2,3 models describe
Heisenberg antiferromagnets with collinear N\'{e}el correlations, and
experimental realizations of quantum-critical behavior in these systems are
discussed. Finally, the N=2, d=2 model describes the superfluid-insulator
transition in lattice boson systems: the frequency and temperature dependence
of the the conductivity at the quantum-critical coupling is described and
implications for experiments in two-dimensional thin films and inversion layers
are noted.Comment: Lectures presented at the NATO Advanced Study Institute on "Dynamical
properties of unconventional magnetic systems", Geilo, Norway, April 2-12,
1997, edited by A. Skjeltorp and D. Sherrington, Kluwer Academic, to be
published. 46 page
For which side the bell tolls: The laterality of approach-avoidance associative networks
The two hemispheres of the brain appear to play different roles in emotion and/or motivation. A great deal of previous research has examined the valence hypothesis (left hemisphere = positive; right = negative), but an increasing body of work has supported the motivational hypothesis (left hemisphere = approach; right = avoidance) as an alternative. The present investigation (N = 117) sought to provide novel support for the latter perspective. Left versus right hemispheres were briefly activated by neutral lateralized auditory primes. Subsequently, participants categorized approach versus avoidance words as quickly and accurately as possible. Performance in the task revealed that approach-related thoughts were more accessible following left-hemispheric activation, whereas avoidance-related thoughts were more accessible following right-hemispheric activation. The present results are the first to examine such lateralized differences in accessible motivational thoughts, which may underlie more “downstream” manifestations of approach and avoidance motivation such as judgments, decision making, and behavior
Defending the genome from the enemy within:mechanisms of retrotransposon suppression in the mouse germline
The viability of any species requires that the genome is kept stable as it is transmitted from generation to generation by the germ cells. One of the challenges to transgenerational genome stability is the potential mutagenic activity of transposable genetic elements, particularly retrotransposons. There are many different types of retrotransposon in mammalian genomes, and these target different points in germline development to amplify and integrate into new genomic locations. Germ cells, and their pluripotent developmental precursors, have evolved a variety of genome defence mechanisms that suppress retrotransposon activity and maintain genome stability across the generations. Here, we review recent advances in understanding how retrotransposon activity is suppressed in the mammalian germline, how genes involved in germline genome defence mechanisms are regulated, and the consequences of mutating these genome defence genes for the developing germline
Structural basis of nucleosome assembly by the Abo1 AAA+ ATPase histone chaperone
The fundamental unit of chromatin, the nucleosome, is an intricate structure that requires histone chaperones for assembly. ATAD2 AAA+???ATPases are a family of histone chaperones that regulate nucleosome density and chromatin dynamics. Here, we demonstrate that the fission yeast ATAD2 homolog, Abo1, deposits histone H3???H4 onto DNA in an ATP-hydrolysis-dependent manner by in vitro reconstitution and single-tethered DNA curtain assays. We present cryo-EM structures of an ATAD2 family ATPase to atomic resolution in three different nucleotide states, revealing unique structural features required for histone loading on DNA, and directly visualize the transitions of Abo1 from an asymmetric spiral (ATP-state) to a symmetric ring (ADP- and apo-states) using high-speed atomic force microscopy (HS-AFM). Furthermore, we find that the acidic pore of ATP-Abo1 binds a peptide substrate which is suggestive of a histone tail. Based on these results, we propose a model whereby Abo1 facilitates H3???H4 loading by utilizing ATP
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