Spatial Determinants of Productivity: Analysis for the Regions of Great Britain

This paper uses NUTS3 sub-regional data for Great Britain to analyse the determinants of spatialvariations in income and productivity. We decompose the spatial variation of earnings into aproductivity effect and an occupational composition effect. For the former (but not the latter) wefind a robust relationship with proximity to economic mass, suggesting that doubling thepopulation of working age proximate to an area is associated with a 3.5% increase in productivityin the area. We measure proximity by travel time, and show that effects decline steeply with time,ceasing to be important beyond approximately 80 minutes.regional disparities, productivity, clustering

Economic Linkages Across Space

We develop a diagrammatic framework that can be used to study the economic linkages between regions or cities. Hitherto, such linkages have not been the primary focus of either the theoretical or empirical literatures. We show that our general framework can be used to interpret both the New Economic Geography and Urban Systems literatures to help us understand spatial economic linkages. We then extend the theoretical framework to allow us to consider a number of additional issues which may be particularly important for analyzing the impact of policy. Such policy analysis will also require empirical work to identify the nature of key relationships. In a final section, we consider what the existing empirical literature can tell us about these relationships.Spatial linkages, Urban systems, New Economic Geography, Urban and regional policy

Introducing a Hybrid Method of Radiative Transfer in Smoothed Particle Hydrodynamics

We present a new method of incorporating radiative transfer into Smoothed Particle Hydrodynamics (SPH). There have been many recent attempts at radiative transfer in SPH (Stamatellos et al 2005, 2005, Mayer et al 2007, Whitehouse and Bate 2006), however these are becoming increasingly complex, with some methods requiring the photosphere to be mapped (which is often of non-trivial geometric shape), and extra conditions to be applied there (matching atmospheres as in Cai et al (2008), or specifying cooling at the photosphere as in Mayer et al (2007)). The method of identifying the photosphere is usually a significant addition to the total simulation runtime, and often requires extra free parameters, the changing of which will affect the final results. Our method is not affected by such concerns, as the photosphere is constructed implicitly by the algorithm without the need for extra free parameters. The algorithm used is a synergy of two current formalisms for radiative effects: a) the polytropic cooling formalism proposed by Stamatellos et al (2007), and b) flux-limited diffusion, used by many authors to simulate radiation transport in the optically thick regime (e.g. Mayer et al 2007). We present several tests of this method: (1) The evolution of a 0.07 solar mass protoplanetary disc around a 0.5 solarmass star (Pickett et al 2003, Mejia et al 2005, Boley et al 2006, Cai et al 2008); (2) The collapse of a non-rotating 1 solar mass molecular cloud (Masunaga & Inutsuka 2000, Stamatellos et al 2007); (3) The thermal relaxation of temperature fluctuations in an static homogeneous sphere (Masunaga et al 1998, Spiegel 1957, Stamatellos et al 2007)Comment: 4 pages, 6 figures, to appear in the proceedings of the Cool Stars 15 conferenc

Topical tacrolimus 0.1% ointment for treatment of cutaneous Crohn's Disease

Peer reviewedPublisher PD

Antimicrobial Resistance in Neisseria gonorrhoeae: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting

The goal of the Sexually Transmitted Infection Clinical Trial Group\u27s Antimicrobial Resistance (AMR) in Neisseria gonorrhoeae (NG) meeting was to assemble experts from academia, government, nonprofit and industry to discuss the current state of research, gaps and challenges in research and technology and priorities and new directions to address the continued emergence of multidrug-resistant NG infections. Topics discussed at the meeting, which will be the focus of this article, include AMR NG global surveillance initiatives, the use of whole genome sequencing and bioinformatics to understand mutations associated with AMR, mechanisms of AMR, and novel antibiotics, vaccines and other methods to treat AMR NG. Key points highlighted during the meeting include: (i) US and International surveillance programs to understand AMR in NG; (ii) the US National Strategy for combating antimicrobial-resistant bacteria; (iii) surveillance needs, challenges, and novel technologies; (iv) plasmid-mediated and chromosomally mediated mechanisms of AMR in NG; (v) novel therapeutic (eg, sialic acid analogs, factor H [FH]/Fc fusion molecule, monoclonal antibodies, topoisomerase inhibitors, fluoroketolides, LpxC inhibitors) and preventative (eg, peptide mimic) strategies to combat infection. The way forward will require renewed political will, new funding initiatives, and collaborations across academic and commercial research and public health programs

An Educational Data Mining Model for Online Teaching and Learning

This study contains two major parts. First, this study proposed a generic model for Educational Data Ming (EDM) studies by reviewing EDM literature and the existing data mining model. Second, the procedures of the EDM model are demonstrated with a case study approach. The case study results showed patterns and relationships discovered from the EDM model that could be applied to improve online teaching and learning and to predict students’ academic performances

Economic Analysis of Children's Surgical Care in Low- and Middle-Income Countries: A Systematic Review and Analysis.

BackgroundUnderstanding the economic value of health interventions is essential for policy makers to make informed resource allocation decisions. The objective of this systematic review was to summarize available information on the economic impact of children's surgical care in low- and middle-income countries (LMICs).MethodsWe searched MEDLINE (Pubmed), Embase, and Web of Science for relevant articles published between Jan. 1996 and Jan. 2015. We summarized reported cost information for individual interventions by country, including all costs, disability weights, health outcome measurements (most commonly disability-adjusted life years [DALYs] averted) and cost-effectiveness ratios (CERs). We calculated median CER as well as societal economic benefits (using a human capital approach) by procedure group across all studies. The methodological quality of each article was assessed using the Drummond checklist and the overall quality of evidence was summarized using a scale adapted from the Agency for Healthcare Research and Quality.FindingsWe identified 86 articles that met inclusion criteria, spanning 36 groups of surgical interventions. The procedure group with the lowest median CER was inguinal hernia repair ($15/DALY). The procedure group with the highest median societal economic benefit was neurosurgical procedures ($58,977). We found a wide range of study quality, with only 35% of studies having a Drummond score ≥ 7.InterpretationOur findings show that many areas of children's surgical care are extremely cost-effective in LMICs, provide substantial societal benefits, and are an appropriate target for enhanced investment. Several areas, including inguinal hernia repair, trichiasis surgery, cleft lip and palate repair, circumcision, congenital heart surgery and orthopedic procedures, should be considered "Essential Pediatric Surgical Procedures" as they offer considerable economic value. However, there are major gaps in existing research quality and methodology which limit our current understanding of the economic value of surgical care