Alveolar and Lactogenic Differentiation

The mouse mammary gland is a complex tissue that proliferates and differentiates under the control of systemic hormones during puberty, pregnancy and lactation. Once a highly branched milk duct system has been established, during mid/late pregnancy, alveoli, little saccular outpouchings, sprout all over the ductal system and differentiate to become the sites of milk secretion. Here, we review the emerging network of the signaling pathways that connects hormonal stimuli with locally produced signaling molecules and the components of intracellular pathways that regulate alveologenesis and lactation. The powerful tools of mouse genetics have been instrumental in uncovering many of the signaling components involved in controlling alveolar and lactogenic differentiatio

ASSISTIVE TECHNOLOGY FOR EDUCATING PERSONS WITH INTELLECTUAL DISABILITY

Technology has changed and continues to change the way people manage things in their lives and it is analogous in the life of Persons with Disabilities (PwDs) through integration of technology in education. Meaningful inclusive education can be made possible with the help of Assistive Technology (AT) since it helps in identifying and overcoming all barriers for effective, continuous and quality participation of all PwDs including those with intellectual disabilities in education. This article attempts to put forward few measures that provide effective education to Persons with Intellectual Disability through the support of assistive technology specifically designed by understanding their educational needs in order to maximize their academic success. Assistive technology pertinent to various domains of education and developmental areas with appropriate examples and case study is also being illustrated. Barriers to access assistive technology and recommendations to remediate it are also discussed in comprehensive manner.  Article visualizations

A Study on Virana Silethumam

The aim of the study is to study the efficacy of Malli Chooranam for the management of virana silethumam with reduction of clinical symptoms. The Siddhars with their tremendous foreseeing and unfathomable knowledge have clearly mentioned the symptomatology, etiology and treatment of Virana Silethumam. The acute toxicity study confirmed the safety of the drug and dosing among pediatric population. For the clinical study, 40 cases were selected from Department of Kuzhanthai Maruthuvam of Ayothidass Pandithar Hospital of National Institute of Siddha, Chennai. Clinical diagnosis was done by means of Siddha and Modern Methodology. The trial subjects were treated with Malli Chooranam twice daily according to the age group. Based on the reporting patients, the improvement in the condition of the patients was observed from the second day itself. Within 4 days, patient showed good relief in symptoms. Observations made during the clinical study showed that the trial drug was clinically effective. Clinically, Malli Chooranam had significant analgesic, anti-pyretic and anti-inflammatory action enough to produce clinical effects. In clinical observation, it was found that 80% of the patients showed good relief in signs and symptoms. Further, there was no development of any adverse drug reactions in the pediatric population. CONCLUSION: Clinical trial with Malli Chooranam showed remarkably good results in the management of Virana silethumam without producing any adverse drug effects. A safe herbal formulation that can be which is clinically efficacious in treating even acute inflamed conditions like acute pharyngo - tonsillitis. The drug can be safely administered to small infants in the event of recurrent episodes due to climatic changes. Thus, it is concluded that in a developing countries like ours, the treatment with Malli Chooranam will be safe, efficacious and easily available with cost effective ingredients for the welfare of pediatric population

ELM-ANFIS Based Controller for Plug-In Electric Vehicle to Grid Integration

An Adaptive Neuro Fuzzy Inference System (ANFIS) based Extreme Learning Machine (ELM) theory is utilised in this research work. In particular, the proposed algorithm is applied for designing a controller for electric vehicle to grid (V2G) integration in smart grid scenario. Initially, learning speed and accuracy of this proposed approach are continuously monitored and then, the performance of ELM-ANFIS (e-ANFIS) based controller is examined for its transient response. The proposed new learning technique overcomes the slow learning speed of the conventional ANFIS algorithm without sacrificing the generalization capability. Hence, a control practice for their charge and discharge patterns can be easily calculated even with the presence of large numbers of Plug-in Hybrid Electric Vehicles (PHEV). To examine the computational performance and transient response of the e-ANFIS based controller, it is evaluated with the usual ANFIS supported controller. The IEEE 33 bus radial distribution system based approach is implemented to ensure the sturdiness of this prescribed approach

Comparative study of the Efficacy of Various Topical Treatment Modalities in Palmoplantar Psoriasis.

INTRODUCTION : Psoriasis is a common, genetically determined, inflammatory and proliferative disease of the skin. The most characteristic lesions consist of red, scaly, sharply demarcated, indurated plaques present particularly on the elbows, knees, lowerback, extensor surfaces and scalp. The first recognisable description of psoriasis is attributed to Celsus (25BC-45AD) in his de re medica nearly 2000 years ago. The disease was described under the heading of impetigo from the Latin word impeto which means "to attack or rush on" Galen was the first to use the word psoriasis from the Greek work 'psora' which means 'to itch'. Psoriasis and Leprosy were grouped together for centuries. Willan was the first to accurately describe psoriasis and its various manifestations in 1809, but he did not separate it with certainty from Leprosy. In 1841, Hebra definitively distinguished the clinical picture of psoriasis from that of Hansen's disease. Eventhough a number of treatment modalities are available, psoriasis continues to be a therapeutic challenge in spite of our growing knowledge of its pathogenesis. AIM OF THE STUDY : Palmoplantar psoriasis is a chronic disease with remissions and exacerbations. Most of the topical therapies currently available for psoriasis are either suited for short term therapy or long term maintenance therapy. Furthermore topical corticosteroids commonly used for palmplantar psoriasis, show diminished response on continuous use due to tachypylaxis and more incidence of recurrence. OBJECTIVE : To compare the efficacy of various topical therapies like Short contact compound dithranol ointment (dithranol 1.15%, salicylic acid 1.15%, coal tar solution 5.3% in white soft paraffin) Topical 0.1% Betamethasone valerate ointment Topical tazarotene 0.05% gel Topical PUVA using -1% methoxypsoralen solution Liquid paraffin. CONCLUSION : Topical therapies are the first line therapeutic strategy in the treatment of localized palmoplantar psoriasis and can be made effective when the appropriate drugs were used judiciously. Among the five modalities compared in this study, tazarotene (0.05%) gel may be considered as an initial treatment of choice. Topical PUVA is as effective as tazarotene except for the limiting factors for PUVA therapy such as availability of PUVA unit, patient compliance and long term side effects. Topical dithranol is as effective as topical PUVA when used as 20minutes short contact therapy. Topical 0.1% Betamethasone valerate was moderately effective with frequent exacerbation. Liquid paraffin was the least effective with no adverse effects, no exacerbation and remissions. However it can be used as an adjunct with other topical therapies

Influence of Electrospun Nanofibrons Architecture in Separation Technology

Ph.DDOCTOR OF PHILOSOPH

Compare the Effectiveness of Kinesio Taping and Splinting to Enhance Self Care and Hand Function in Children with Spastic Cerebral Palsy.

OBJECTIVE: The purpose of this study is to compare the effectiveness of kinesio Taping and splinting to enhance self care and hand function in children with spastic cerebral palsy. METHODOLOGY: 22 children (12 males and 10 females; 3 to 9 years of age) participated in this study. The Paediatric Evaluation of Disability Inventory (PEDI) and Earhart Developmental Prehension Assessment (EDPA) were used to measure pre and post score of self care and hand function. 11 children in experimental group received Kinesio Taping and 11 children in control group received splinting intervention. After 12 weeks of intervention duration the post test scores were taken in both the groups. Again a 3rd evaluation was done 15 days after the removal of kinesio Taping and splinting to determine the lasting effects on self care and hand function performance. RESULTS: SPSS version 18 was used to analyse the study results. Descriptive and Inferential statistics were used to analyse the data’s obtained. In both groups results showed statistical differences at 0.01 level in paired sample statistics. In independent sample statistics the Kinesio Taping group showed significant improvement in most of the components comparatively splinting group. CONCLUSION: The study comparison confirm that the use of Kinesio Tape as an adjunct to treatment may assist with hand function and self care in occupational therapy pediatric rehabilitation settings than the dorsal cock-up with thumb opponens splint on thumb-in-palm deformity for children with spastic cerebral palsy