4,366 research outputs found

    Pluviometric variations as subsidiary information for agricultural planning in the Amazon.

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    The area of interest for this study lies in the Western part of the Amazon. Monthly and annual meteorological data from 12 places were used, with daily data from eight rain gauges and daily rainfall intensity records. Data were presented from tests of water infiltration into the soil performed in the region. The results showed that the Northwest part of the region was the rainiest, attaining annual means of 3,333 mm at Iauaretê. In the Southern part, beginning at 5°S, the mean values reached 1,952 mm, at Rio Branco. Mean annual rainfalls ranged from 2,500 mm to 2,200 mm, in the region. The lowest pluvial total was 1,365 mm, which occurred at Parintins in 1983, and may be associated to the effects of a strong El Niño (82-83). In years when La Niña was strong, rainfalls were above the average and when El Niño was strong, they were below the average. The rainiest period was from December to April with means above 160 mm and the least rainy was from May to September, August being the month with the lowest rainfall. Close to Humaitá, annual rainfalls were less than 2,000 mm

    Tuning hole mobility in InP nanowires

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    Transport properties of holes in InP nanowires were calculated considering electron-phonon interaction via deformation potentials, the effect of temperature and strain fields. Using molecular dynamics, we simulate nanowire structures, LO-phonon energy renormalization and lifetime. The valence band ground state changes between light- and heavy-hole character, as the strain fields and the nanowire size are changed. Drastic changes in the mobility arise with the onset of resonance between the LO-phonons and the separation between valence subbands.Comment: 4 pages, 4 figure

    WT1 and its transcriptional cofactor BASP1 redirect the differentiation pathway of an established blood cell line

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    The Wilms' tumour suppressor WT1 (Wilms' tumour 1) is a transcriptional regulator that plays a central role in organogenesis, and is mutated or aberrantly expressed in several childhood and adult malignancies. We previously identified BASP1 (brain acid-soluble protein 1) as a WT1 cofactor that suppresses the transcriptional activation function of WT1. In the present study we have analysed the dynamic between WT1 and BASP1 in the regulation of gene expression in myelogenous leukaemia K562 cells. Our findings reveal that BASP1 is a significant regulator of WT1 that is recruited to WT1-binding sites and suppresses WT1-mediated transcriptional activation at several WT1 target genes. We find that WT1 and BASP1 can divert the differentiation programme of K562 cells to a non-blood cell type following induction by the phorbol ester PMA. WT1 and BASP1 co-operate to induce the differentiation of K562 cells to a neuronal-like morphology that exhibits extensive arborization, and the expression of several genes involved in neurite outgrowth and synapse formation. Functional analysis revealed the relevance of the transcriptional reprogramming and morphological changes, in that the cells elicited a response to the neurotransmitter ATP. Taken together, the results of the present study reveal that WT1 and BASP1 can divert the lineage potential of an established blood cell line towards a cell with neuronal characteristics

    Aspectos climáticos do noroeste fluminense, RJ.

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    bitstream/CNPS/11829/1/doc_43_2003_noroeste_fluminense.pd

    WT1 and its transcriptional cofactor BASP1 redirect the differentiation pathway of an established blood cell line

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    The Wilms' tumour suppressor WT1 (Wilms' tumour 1) is a transcriptional regulator that plays a central role in organogenesis, and is mutated or aberrantly expressed in several childhood and adult malignancies. We previously identified BASP1 (brain acid-soluble protein 1) as a WT1 cofactor that suppresses the transcriptional activation function of WT1. In the present study we have analysed the dynamic between WT1 and BASP1 in the regulation of gene expression in myelogenous leukaemia K562 cells. Our findings reveal that BASP1 is a significant regulator of WT1 that is recruited to WT1-binding sites and suppresses WT1-mediated transcriptional activation at several WT1 target genes. We find that WT1 and BASP1 can divert the differentiation programme of K562 cells to a non-blood cell type following induction by the phorbol ester PMA. WT1 and BASP1 co-operate to induce the differentiation of K562 cells to a neuronal-like morphology that exhibits extensive arborization, and the expression of several genes involved in neurite outgrowth and synapse formation. Functional analysis revealed the relevance of the transcriptional reprogramming and morphological changes, in that the cells elicited a response to the neurotransmitter ATP. Taken together, the results of the present study reveal that WT1 and BASP1 can divert the lineage potential of an established blood cell line towards a cell with neuronal characteristics

    Students' Models of Newton's Second Law in Mechanics and Electromagnetism

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    We investigated students' use of Newton's second law in mechanics and electromagnetism contexts by interviewing students in a two-semester calculus-based physics course. We observed that students' responses are consistent with three mental models. These models appeard in mechanics contexts and were transferred to electromagnetism contexts. We developed an inventory to help instructors identify these models and direct students towards the correct one.Comment: 15 pages, 3 figues and 4 table
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