Crowd sourcing of public transport problems

Social sites on the World Wide Web allow increased sharing of ideas and problems. Such online networking includes the ability to report public transport problems and get support for campaigns to improve specific aspects of public transport. One site that offers such a facility provided access to its data on problems that were reported over a 13 month period. These were assessed and comparisons were made to see if those campaigns that got the most support were inherently different to the campaigns that received little support, and to investigate the types of problems that were reported online. Whilst definitive answers cannot be given, there are some suggestions that come out of the analysis and the overall impact on improving public transport accessibility and usability is discussed

Failure to activate the IFN-beta promoter by a paramyxovirus lacking an interferon antagonist

It is generally thought that pathogen-associated molecular patterns (PAMPs) responsible for triggering interferon (IFN) induction are produced during virus replication and, to limit the activation of the IFN response by these PAMPs, viruses encode antagonists of IFN induction. Here we have studied the induction of IFN by parainfluenza virus type 5 (PIV5) at the single-cell level, using a cell line expressing GFP under the control of the IFN-β promoter. We demonstrate that a recombinant PIV5 (termed PIV5-VΔC) that lacks a functional V protein (the viral IFN antagonist) does not activate the IFN-β promoter in the majority of infected cells. We conclude that viral PAMPs capable of activating the IFN induction cascade are not produced or exposed during the normal replication cycle of PIV5, and suggest instead that defective viruses are primarily responsible for inducing IFN during PIV5 infection in this syste

Combining Distribution and Dispersal Models to Identify a Particularly Vulnerable Marine Ecosystem

Habitat suitability models are being used worldwide to help map and manage marine areas of conservation importance and scientific interest. With groundtruthing, these models may be found to successfully predict patches of occurrence, but whether all patches are part of a larger interbreeding metapopulation is much harder to assert. Here we use a North Atlantic deep-sea case study to demonstrate how dispersal models may help to complete the picture. Pheronema carpenteri is a deep-sea sponge that, in aggregation, forms a vulnerable marine ecosystem in the Atlantic Ocean. Published predictive distribution models from United Kingdom and Irish waters have now gained some support from targeted groundtruthing, but known aggregations are distantly fragmented with little predicted habitat available in-between. Dispersal models were used to provide spatial predictions of the potential connectivity between these patches. As little is known of P. carpenteri’s reproductive methods, twenty-four model set-ups with different dispersal assumptions were simulated to present a large range of potential dispersal patterns. The results suggest that up to 53.1% of the total predicted habitat may be reachable in one generation of dispersal from known populations. Yet, even in the most dispersive scenario, the known populations in the North (Hatton-Rockall Basin) and the South (Porcupine Sea Bight) are predicted to be unconnected, resulting in the relative isolation of these patches across multiple generations. This has implications for Ireland’s future conservation efforts as they may have to conserve patches from more than one metapopulation. This means that conserving one patch may not demographically support the other, requiring additional attentions to ensure that marine protected areas are ecologically coherent and sustainable. This example serves as a demonstration of a combined modeling approach where the comparison between predicted distribution and dispersal maps can highlight areas with higher conservation needs.publishedVersio

Towards ‘ecological coherence’: Assessing larval dispersal within a network of existing Marine Protected Areas

The Convention on Biological Diversity mandates the establishment of Marine Protected Area (MPA) networks worldwide, with recommendations stating the importance of ‘ecological coherence’ (a responsibility to support and perpetuate the existing ecosystem) implying the need to sustain population connectivity. While recommendations exist for integrating connectivity data into MPA planning, little advice exists on how to assess the connectivity of existing networks. This study makes use of recently observed larval characteristics and freely available models to demonstrate how such an assessment could be undertaken. The cold water coral (CWC) Lophelia pertusa (Linnaeus, 1758) is used as a model species, as much of the NE Atlantic MPA network has been designated for CWC reef protection, but the ecological coherence of the network has yet to be assessed. Simulations are run for different behavioural null models allowing a comparison of ‘passive’ (current driven) and ‘active’ (currents + vertical migration) dispersal, while an average prediction is used for MPA assessment. This model suggests that the network may support widespread larval exchange and has good local retention rates but still has room for improvement. The best performing MPAs were large and central to the network facilitating transport across local dispersal barriers. On average, passive and active dispersal simulations gave statistically similar results, providing encouragement to future local dispersal assessments where active characteristics are unknown

Use of Simulation to Visualize Healthcare Worker Exposure to Aerosol in the Operating Room

Simulation resources offer an opportunity to highlight aerosol dispersion within the operating room environment. We demonstrate our methodology with a supporting video that can offer operating room teams support in their practical understanding of aerosol exposure and the importance of personal protective equipment

Comparing Deep-Sea Larval Dispersal Models: A Cautionary Tale for Ecology and Conservation

Larval dispersal data are increasingly sought after in ecology and marine conservation, the latter often requiring information under time limited circumstances. Basic estimates of dispersal [based on average current speeds and planktonic larval duration (PLD)] are often used in these situations, usually acknowledging their oversimplified nature, but rarely with an understanding of how oversimplified those assumptions are. Larval dispersal models (LDMs) are becoming more accessible and may produce “better” dispersal predictions than estimates, but the uncertainty introduced by choosing one underlying hydrodynamic model over another is rarely discussed. This case study uses theoretical and simplified deep-sea LDMs to compare the passive predictions of dispersal as driven by two different hydrodynamic models (HYCOM and POLCOMS) and a range of informed basic estimates (based on average current speeds of 0.05, 0.1, and 0.2 m/s). The aim is to provide generalizable insight into the predictive variability introduced by (a) choosing a model over an estimate, and (b) one hydrodynamic over another. LDMs were found to be up to an order of magnitude more conservative in dispersal distance predictions than even the slowest tested estimate (0.05 m/s). The difference increased with PLD which may result in a bigger disparity for deep-sea species predictions. Although the LDMs were more spatially targeted than the estimates, the two LDM predictions were also significantly different from each other. This means that choosing one hydrodynamic model over another could result in contrasting ecological interpretations or advice for marine conservation. These results show a greater potential for hydrodynamic model variability than previously appreciated by larval dispersal ecologists and strongly advocates groundtruthing predictions before use in management. Advice is offered for improved model selection and interpretation of predictions.publishedVersio

Right Hemisphere Partial Complex Seizures: Mania, Hallucinations, and Speech Disturbances During Ictal Events

A patient with right hemisphere complex partial seizures exhibited extreme emotional lability resembling mania, neologisms resembling those found in fluent aphasia, and hallucinations during ictal periods. The electroencephalographic and clinical findings in this case suggest that cortical and subcortical structures of the right hemisphere may play a role in mediating the expression of language content. RÉSUMÉ Chez un patient prÉsentant des crises partielles complexes de l'hÉmisphÈre droit, nous avons observÉ pendant les crises une labilitÉÉmotionnelle Évoquant le diagnostic de manie. des nÉologismes ressemblant À ceux de l'aphasie de Wernicke et des hallucinations. Nos constatation EEG et cliniques suggÈrent que les structures corticales et sous-corticales de l'hÉmisphÈre droit peuvent jouer un rÔle dans la mÉdiation de l'expression du contenu linguistique. RESUMEN Un paciente con ataques parciales complejos originados en el hemisferio derecho mostrÓ una labilidad emocional extrema semejante a la mania, neologismos comparables a los que se encuentran en la afasia fluida y alucinaciones durante los perÍodos ictales. Los hallazgos clÍnicos y del EEG en este caso sugieren que estructuras corticales y subcorticales del hemisferio derecho pueden jugar un papel en la funciÓn del contenido del lenguaje expresivo.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66016/1/j.1528-1157.1988.tb05093.x.pd

Diagnostics for assessing city-wide sanitation services

Abstract This paper presents results of research that has developed a set of diagnostic and decision-support tools for assessing sanitation services city-wide. It highlights features of the tools and illustrates key results from their validation through application in five cities worldwide. Collective use of these tools reveals and explains the complexities of the enabling environment and political economy within which sanitation services are delivered. Results present not only the status quo of services but also reasons for them being so. The tools have proven effective in guiding the collection, analysis and discussion of evidence, as a precursor to detailed feasibility studies, necessary to ultimately plan appropriate city-wide sanitation interventions.</jats:p

Dupuytren's disease in bosnia and herzegovina. An epidemiological study

BACKGROUND: It is generally held that Dupuytren's disease is more common in northern than in southern Europe, but there are very few studies from southern European countries. METHODS: We examined the hands of 1207 men and women over the age of 50 years in Bosnia and Herzegovina. RESULTS: The prevalence of Dupuytren's disease was highly age-dependent, ranging from 17% for men between 50–59 years to 60% in the oldest men. The prevalence among women was lower. The great majority only had palmar changes without contracture of the digit. The prevalence was significantly lower among Bosnian Muslim men than among Bosnian Croat and Serbian men and significantly increased among diabetics. No association could be detected between Dupuytren's disease and smoking, alcohol consumption or living in rural or urban areas. CONCLUSION: We conclude that, contrary to previous opinion, Dupuytren's disease is common in Bosnia and Herzegovina