Accelerated Hydrolysis of Aspirin Using Alternating Magnetic Fields

The major problem of current drug-based therapy is selectivity. As in other areas of science, a combined approach might improve the situation decisively. The idea is to use the pro-drug principle together with an alternating magnetic field as physical stimulus, which can be applied in a spatially and temporarily controlled manner. As a proof of principle, the neutral hydrolysis of aspirin in physiological phosphate buffer of pH 7.5 at 40 °C was chosen. The sensor and actuator system is a commercially available gold nanoparticle (NP) suspension which is approved for animal usage, stable in high concentrations and reproducibly available. Applying the alternating magnetic field of a conventional NMR magnet system accelerated the hydrolysis of aspirin in solution

Sonographic assessment of renal length in children: A reappraisal

Ultrasonography (US) has largely replaced the intravenous urogram as the first modality for the evaluation of the kidneys in children suspected of having urinary tract abnormalities. Because many renal disorders are associated with changes in the sizes of the kidneys, normative standards for assessing renal size have been developed. These standards rely upon comparison of the renal lengths or calculated volumes or both, with various assessments of overall body size, including body surface area, weight, height, and chronological age. We discuss some of the limitations of US in assessing renal size in children. Practical recommendations are offered for optimizing the measurement and interpretation of sonographic renal sizes in children.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46703/1/247_2005_Article_BF02020164.pd

Effect of mass ratio on hydrodynamic response of a flexible cylinder

The effect of the mass ratio on the flow-induced vibration (FIV) of a flexible circular cylinder is experimentally investigated in a towing tank. A Tygon tube with outer and inner diameters of 7.9 mm and 4.8 mm, respectively, was employed for the study. The tube was connected to a carriage and towed from rest to a steady speed up to 1.6 m/s before slowing down to rest again over a distance of 1.6 m in still water. Reynolds number based on the cylinder’s outer diameter was 800–13,000, and the reduced velocity (velocity normalized by the cylinder’s natural frequency and outer diameter) spanned from 2 to 25. When connected, the cylinder was elongated from 420 mm to 460 mm under an axial pre-tension of 11 N. Based on the cylinder’s elongated length, the aspect ratio (ratio of the cylinder’s length to outer diameter) was calculated as 58. Three mass ratios (ratio of the cylinder’s structural mass to displaced fluid mass, m*) of 0.7, 1.0, and 3.4 were determined by filling the cylinder’s interior with air, water, and alloy powder (nickel-chromium-boron matrix alloy), respectively. An optical method was adopted for response measurements. Multi-frequency vibrations were observed in both in-line (IL) and cross-flow (CF) responses; at high Reynolds number, vibration modes up to the 3rd one were identified in the CF response. The mode transition was found to occur at a lower reduced velocity for the highest tested mass ratio. The vibration amplitude and frequency were quantified and expressed with respect to the reduced velocity. A significant reduced vibration amplitude was found in the IL response with increasing mass ratios, and only initial and upper branches existed in the IL and CF response amplitudes. The normalized response frequencies were revealed to linearly increase with respect to the reduced velocity, and slopes for linear relations were found to be identical for the three cases tested