A IMPORTÂNCIA DO USO DE CARTILHAS INFORMATIVAS NA DISSEMINAÇÃO DO USO DE APLICATIVOS DIGITAIS DE APRENDIZAGEM COMO RECURSO PEDAGÓGICO

O objetivo deste trabalho é elaborar uma cartilha digital para professores que apresente o aplicativo Kahoot como Objeto de Aprendizagem Digital (OAD) para alunos do ensino médio numa escola da rede pública estadual. Este estudo conta com uma abordagem metodológica, sendo dividido nas seguintes etapas: 1. Revisão bibliográfica; 2. Elaboração do material educativo e 3. Validação e divulgação do material para o público alvo. Confia-se que o uso deste material será capaz de favorecer as informações necessárias para colaborar com a prática pedagógica de inúmeros profissionais, tendo em vista que por se tratar de um objeto digital de aprendizagem, o mesmo poderá ser compartilhado facilmente por e-mail e os usuários poderão acessar não apenas de um computador, como também de tablets e aparelhos celulares. Como um profissional que deve estar sempre se atualizando, o professor irá se apropriar dos conhecimentos contidos na cartilha produzida de maneira dinâmica e descomplicada. Além de contribuir para a prática pedagógica de muitos profissionais, esse material também auxiliará na formação destes.</jats:p

Pharmacological study of anti-allergic activity of Syzygium cumini (L.) Skeels

Myrtaceae is a plant family widely used in folk medicine and Syzygium and Eugenia are among the most important genera. We investigated the anti-allergic properties of an aqueous leaf extract of Syzygium cumini (L.) Skeels (SC). HPLC analysis revealed that hydrolyzable tannins and flavonoids are the major components of the extract. Oral administration of SC (25-100 mg/kg) in Swiss mice (20-25 g; N = 7/group) inhibited paw edema induced by compound 48/80 (50% inhibition, 100 mg/kg; P <= 0.05) and, to a lesser extent, the allergic paw edema (23% inhibition, 100 mg/kg; P <= 0.05). SC treatment also inhibited the edema induced by histamine (58% inhibition; P <= 0.05) and 5-HT (52% inhibition; P <= 0.05) but had no effect on platelet-aggregating factor-induced paw edema. SC prevented mast cell degranulation and the consequent histamine release in Wistar rat (180-200 g; N = 7/group) peritoneal mast cells (50% inhibition, 1 µg/mL; P <= 0.05) induced by compound 48/80. Pre-treatment of BALB/c mice (18-20 g; N = 7/group) with 100 mg/kg of the extract significantly inhibited eosinophil accumulation in allergic pleurisy (from 7.662 ± 1.524 to 1.89 ± 0.336 x 10(6)/cavity; P <= 0.001). This effect was related to the inhibition of IL-5 (from 70.9 ± 25.2 to 12.05 ± 7.165 pg/mL) and CCL11/eotaxin levels (from 60.4 ± 8.54 to 32.8 ± 8.4 ng/mL) in pleural lavage fluid, using ELISA. These findings demonstrate an anti-allergic effect of SC, and indicate that its anti-edematogenic effect is due to the inhibition of mast cell degranulation and of histamine and serotonin effects, whereas the inhibition of eosinophil accumulation in the allergic pleurisy model is probably due to an impairment of CCL11/eotaxin and IL-5 production

Clinical characteristics and thyroid function in complete hydatidiform mole complicated by hyperthyroidism

Objectives: To identify possible clinical factors associated with hyperthyroidism at presentation and to assess post-evacuation thyroid function in women with complete hydatidiform mole (CHM). Methods: This observational study included women with CHM attending a specialized Brazilian center in 2002–2018. Clinical and laboratory data (serum hCG, TSH, fT4) were collected at presentation. Factors associated with hyperthyroidism were assessed by logistic regression. Receiver-operating characteristic curves were built to determine the hCG cutoff for predicting hyperthyroidism at CHM presentation. Post-molar evacuation follow-up included clinical assessment and close thyroid function monitoring. Results: Of 137 CHM patients, 69 (50.3%) had hyperthyroidism of any type (43.5% subclinical, 56.5% overt) at presentation. Uterine fundal height > 16 cm or > gestational age (GA), and theca lutein cysts >6 cm were significantly associated with both subclinical and overt hyperthyroidism. The optimal hCG cutoff for predicting hyperthyroidism was 430,559 IU/L (sensitivity 85.5%, specificity 83.8%). Post-evacuation hyperthyroidism/transient hypothyroidism conversion was observed in 13% of the women with hyperthyroidism at presentation. Among the patients not showing conversion to hypothyroidism, median time for TSH normalization was 2 and 3 weeks for subclinical and overt hyperthyroidism, respectively. In the women with overt hyperthyroidism, fT4 was normalized at 2 weeks. Conclusions: Uterine fundal height > 16 cm, uterine fundal height > GA, theca lutein cysts >6 cm, and hCG >400,000 IU/L at presentation are associated with greater risk of hyperthyroidism and its complications. Close monitoring thyroid function during postmolar follow-up showed that, as thyroid hormones are normalized within 2–3 weeks post-evacuation, the use of beta-blockers or antithyroid drugs can be rapidly discontinued.Postgraduation Program in Tocoginecology Botucatu Medical School UNESP-São Paulo State University, SPBotucatu Trophoblastic Disease Center Clinical Hospital of Botucatu Medical School Department of Gynecology and Obstetrics UNESP-São Paulo State University, SPClinical Hospital of Botucatu Medical School Department of Gynecology and Obstetrics UNESP-São Paulo State University, SPEndocrinology Clinic Department of Internal Medicine Botucatu Medical School UNESP-São Paulo State University, SPNew England Trophoblastic Disease Center Division of Gynecologic Oncology Department of Obstetrics Gynecology and Reproductive Biology Brigham and Women's Hospital Harvard Medical SchoolDepartment of Obstetrics and Gynecology Division of Gynecologic Oncology Brigham and Women's HospitalRio de Janeiro Trophoblastic Disease Center Maternity School of Rio de Janeiro Federal University Antonio Pedro University Hospital Fluminense Federal University, RJPostgraduation Program in Tocoginecology Botucatu Medical School UNESP-São Paulo State University, SPBotucatu Trophoblastic Disease Center Clinical Hospital of Botucatu Medical School Department of Gynecology and Obstetrics UNESP-São Paulo State University, SPClinical Hospital of Botucatu Medical School Department of Gynecology and Obstetrics UNESP-São Paulo State University, SPEndocrinology Clinic Department of Internal Medicine Botucatu Medical School UNESP-São Paulo State University, S