206 research outputs found

    HP-sequence design for lattice proteins - an exact enumeration study on diamond as well as square lattice

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    We present an exact enumeration algorithm for identifying the {\it native} configuration - a maximally compact self avoiding walk configuration that is also the minimum energy configuration for a given set of contact-energy schemes; the process is implicitly sequence-dependent. In particular, we show that the 25-step native configuration on a diamond lattice consists of two sheet-like structures and is the same for all the contact-energy schemes, (1,0,0);(7,3,0);(7,3,1);(7,3,1){(-1,0,0);(-7,-3,0); (-7,-3,-1); (-7,-3,1)}; on a square lattice also, the 24-step native configuration is independent of the energy schemes considered. However, the designing sequence for the diamond lattice walk depends on the energy schemes used whereas that for the square lattice walk does not. We have calculated the temperature-dependent specific heat for these designed sequences and the four energy schemes using the exact density of states. These data show that the energy scheme (7,3,1)(-7,-3,-1) is preferable to the other three for both diamond and square lattice because the associated sequences give rise to a sharp low-temperature peak. We have also presented data for shorter (23-, 21- and 17-step) walks on a diamond lattice to show that this algorithm helps identify a unique minimum energy configuration by suitably taking care of the ground-state degeneracy. Interestingly, all these shorter target configurations also show sheet-like secondary structures.Comment: 19 pages, 7 figures (eps), 11 tables (latex files

    Ultrasonic Velocity Studies in Aqueous Lithium Salts

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    Prevalence of Sleep Related Breathing Disorders and the Assessment of Quality of Sleep in Patients with Chronic Hypercapnic Respiratory Failure

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    BACKGROUND: COPD will be the third leading cause of death by year 2020. In India, COPD and Post TuberculousSequelae are very common chronic respiratory diseases that have significant morbidity and mortality.Sleep related symptoms occur in about 40% of cases in patients with COPD. Sleep related breathing disorders constitute the greatest number of disorders of sleep in patients treated by sleep medicine, pulmonary, and general practitioners in the outpatient setting. AIM OF THE STUDY : 1. To know the prevalence of sleep related breathing disorders (SRBD) in patients with Chronic Hypercapnic Respiratory Failure. 2. To assess the quality of sleep in patients with Chronic Hypercapnic Respiratory Failure. MATERIAL AND METHODS: Patients enrolled in the COPD registry at Government Hospital of Thoracic Medicine Tambaram,with severe stable COPD or COPD with Pulmonary Tuberculosis Sequelaeare evaluated. Spirometry is done for those patients. Patients with FEV1< 40% by spirometry are included, Arterial Blood Gas analysis is done. Those with Chronic Hypercapnic Respiratory Failure are included in the study. Patients with similar degree of obstruction without Respiratory Failure are used as comparison group. Overnight Polysomnography was performed in those patients. Epworths Sleepiness Score and Pittsburg sleep quality index scoring is done. Data is analyzed by standard statistical methods. RESULTS: Forty Five patients are enrolled into the study in total. Thirty two patients are Patients with Chronic Hypercapnic Respiratory Failure (Group A). Thirteen patients had COPD or COPD with Pulmonary Tuberculosis sequelae and with similar degrees of airflow obstruction without Respiratory failure (Group B).The mean Age group is 57.2 vs 57.8 years. Significant Nocturnal Desaturation is seen in 68.8% of patients with Group A and 38.5% of patients in Group B. Snoring is present in 41% of Group A and 23.07% of Group B. Obstructive Sleep apnea is seen in 2 patients in Group A (6.25%). Sleep latency (in minutes) is 62.7 vs 42.4. arousal index is 31.1/hour vs 20.4/ hour, NREM1, 2 (in Minutes) 208.1 vs 180.1, NREM3 (Min) is 20.7 vs 33.9, REM (min) 34.7 vs 48.6. In Group A, 68.8 % of patients have significant nocturnal desaturation vs 38.5% in Group B. Mean Epworth Sleepiness score is 11.5 vs 9.7, MeanPSQI score is 13.2vs 7.3. CONCLUSION: Nocturnal Desaturation is seen in significant proportion of patients with Chronic Hypercapnic Respiratory Failure (68.8%). There is good correlation between the Quality of sleep measurement by Pittsburgh Sleep Quality Index scoring and the sleep variables determined by polysomnography. Patients with Chronic Hypercapnic Respiratory Failure have decreased Total Sleep Time, Increased Sleep Latency, Decreased Sleep Efficiency, Decreased NREM Stage 3 Sleep, Decreased REM Sleep, Increased Arousal, Increase in duration of Wake after Sleep Onset when compared to normal values of that age. Based on these variables it is concluded that Sleep Quality in patients with Chronic Hypercapnic Respiratory Failure is poor. The prevalence of sleep related breathing disorders (SRBD) in patients with Chronic Hypercapnic Respiratory Failure is 6.25% which is similar to that general population
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