COVID-19: Policy Interventions and Socio-economic Impact in Andhra Pradesh, India

The COVID-19 pandemic has claimed several lives and has already adversely affected the livelihoods of millions of vulnerable households. This policy brief surveys the current status of the disease, its spread and its likely socio-economic effects in the context of Andhra Pradesh, India. Given the global scope of the shock, the policy brief emphasizes the need for innovative and bold policy measures, particularly from the states’ perspective

Alternate paths to economic development:a comparative analysis of Brazil and India in the era of neoliberalism

ABSTRACT This paper compares and contrasts Brazilian and Indian strategies of development during the era of neo-liberalism from a long period perspective. The Brazilian economy has attempted to combine the goals of redistribution and social equity with the goals of growth and productivity. India on the other hand has pursued a growth maximizing approach to development, while paying little or no attention to the larger goals of human well-being. The article seeks to understand the dynamics of economic change in the two economies and attempts to draw out the institutional and political factors that have influenced these approaches

Technological Innovations, Behavioural Interventions, and Household Energy Conservation: Policy Insights and Lessons

The threats associated with climate change and the worsening ecological crisis have led to a growing interest in energy-conservation policies. Policymakers across the globe have been scrambling to find cost-effective and sustainable methods to meet the world’s growing energy demands. Traditional policies have so far largely focused on supply-side interventions aimed at encouraging energy efficiency via green innovation and new technologies. However, as several studies have indicated, supply-side policies alone are unlikely to be adequate to achieve the ambitious changes required to make our future sustainable. This review article draws on recent studies in behavioural economics to emphasize the need to reorient public policy towards altering consumer end-uses through behavioural interventions. In an attempt to draw out important lessons for public policy, the article reviews this emerging strand of literature and underlines the complex factors that influence energy consumption in a household. Although preceding studies have primarily focused on developed nations, the output of these studies could guide policymakers in developing and emerging market economies as well

COVID-19: Policy Interventions and Socio-economic Impact in Andhra Pradesh, India

The COVID-19 pandemic has claimed several lives and has already adversely affected the livelihoods of millions of vulnerable households. This policy brief surveys the current status of the disease, its spread and its likely socio-economic effects in the context of Andhra Pradesh, India. Given the global scope of the shock, the policy brief emphasizes the need for innovative and bold policy measures, particularly from the states’ perspective

Advances, recognition, and interpretation of molecular heterogeneity among conventional and subtype histology of urothelial carcinoma (UC): a survey among urologic pathologists and comprehensive review of the literature

Aims Urothelial carcinoma (UC) demonstrates significant molecular and histologic heterogeneity. The WHO 2022 classification has hinted at adding molecular signatures to the morphologic diagnosis. As morphology and associated molecular repertoire may potentially translate to choices of and response to therapy and relapse rate, broader acceptability of recognizing these key features among uropathologists is needed. This prompted an international survey to ascertain the practice patterns in classical/subtype UC among uropathologists across the globe. Methods and Results A survey instrument was shared among 98 uropathologists using SurveyMonkey software. Anonymized respondent data were analysed. The response rate was 85%. A majority were in concordance with the profiles of luminal (93%) and basal (82%) types. Opinion on the FGFR3 testing platform was variable. While 95% concurred that TERT promoter mutation is the key driver in UC, 72% had the opinion that APOBEC mutagenesis is the main signature in muscle invasive bladder cancer (MIBC). Uropathologists have divergent opinions on MIBC and ERCC2 mutations. Among the participants, 94% would quantify aggressive micropapillary and sarcomatoid histology, while 88% would reevaluate another transurethral resection of the bladder tumour specimen in nonmuscle invasive tumour with micropapillary, small cell, or sarcomatoid histology. A leading number agreed to specific molecular signatures of micropapillary (93%), plasmacytoid (97%), and small cell (86%) subtypes. Ninety‐six percent of participants agreed that a small‐cell component portends a more aggressive course and should be treated with neoadjuvant chemotherapy and 63% would perform HER2/neu testing only on oncologist's request in advanced tumours. Ninety percent agreed that microsatellite instability testing, although not a standard protocol, should be considered in young patients with upper tract UC. Eighty‐six percent agreed that UC with high tumour mutational burden would be a better candidate for immunotherapy. Conclusion In the era of precision medicine, enhanced understanding of molecular heterogeneity of UC will contribute to better therapeutic options, novel biomarker discovery, innovative management protocols, and outcomes. Our survey provides a broad perspective of pathologists' perceptions and experience regarding incorporation of histomolecular approaches to “personalize” therapy. Due to variable clinical adoption, there is a need for additional data using uniform study criteria. This will drive generation of best practice guidelines in this area for widespread and consistent clinical utility

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field