78 research outputs found
The Effect of Restricted Feeding and Different of Slaughtering Age on Production of Rex Rabbit Pelt
The purpose of this research is to study the interaction between slaughter age and restricted feed, aswell as the influence of each factor on the production of rex rabbits pelt. Randomized Block Designwith Factorial was used in this experiment with the first factor was 3 levels of restricted feedingtreatment where the amount of feed as follow: P1= 100 % from the total feed requirement, P2 = 80%from total feed requirement and P3 = 60% from the total feed requirement. Feed was given in the amountof rabbits requirement, in which 100% of the total requirement was calculated based on body weight(6.7% of body weight in dry matter basis), and second factor was 3 levels of slaughter age (U1= 120 d,U2= 150 d, U3= 180 d) and each treatment was repeated 6 times. The data were analyzed by Anova,and analyzing between the treatments used Contrast Orthogonal. The variable measured were peltproduction (weight pelt, width pelt, thickness dermis and epidermis) of Rex rabbit. There was aninteraction betwen slaughtered age and the amount of feed given to Rex rabbits. Feeding 80% from thetotal feed requirement and the slaughtered age at 150 d were the most efficient in producing pelt of Rexrabbits, with weight 261.0 Β± 30.33 g, width 928.0 Β± 75.5 cm2, and epidermal thickness 32.50 Β± 1.1ΞΌ,and dermis 2685.50 Β± 15.0 ΞΌ
Pengaruh Penambahan Biovet dalam Ransum dengan Berbagai Kandungan Protein-Energi terhadap Pertumbuhan Anak Kelinci Rex
An experiment was conducted to study the effect of Biovet supplement in diets of different protein-energy to weight gain of Rex rabbit kit. The experiment used 112 kit of 28 Rex Rabbits at PT Fiva Bandung Rabitry, Pangkalan village, Sub districk Gambung-Ciwidey District Bandung in Completely Randomized Design 7 treatments and 4 replications. The treatments were: R0: 18% CP and 2750 kcal/kg; DE R1: 16% CP, 2500 kcal/kg DE + 0% Biovet; R2: 16% CP, 2500 kcal/kg DE + 0,1% Biovet; R3: 16% CP, 2500 kcal/kg DE + 0,5% Biovet; R4: 14% CP, 2400 kcal/kg DE + 0% Biovet; R5: 14% CP, 2400 kcal/kg DE + 0,1% Biovet; and R6: 14% CP, 2400 kcal/kg DE + 0,5 % Biovet. Results showed that body weight gain, feed consumption, and conversion were similar to rabbits given biovet supplement in low quality diet
Pengaruh Penambahan Biovet Dalam Ransum Dengan Berbagai Kandungan Protein-Energi Terhadap Pertumbuhan Anak Kelinci Rex
An experiment was conducted to study the effect of Biovet supplement in diets of different protein-energy to weight gain of Rex rabbit kit. The experiment used 112 kit of 28 Rex Rabbits at PT Fiva Bandung Rabitry, Pangkalan village, Sub districk Gambung-Ciwidey District Bandung in Completely Randomized Design 7 treatments and 4 replications. The treatments were: R0: 18% CP and 2750 kcal/kg; DE R1: 16% CP, 2500 kcal/kg DE + 0% Biovet; R2: 16% CP, 2500 kcal/kg DE + 0,1% Biovet; R3: 16% CP, 2500 kcal/kg DE + 0,5% Biovet; R4: 14% CP, 2400 kcal/kg DE + 0% Biovet; R5: 14% CP, 2400 kcal/kg DE + 0,1% Biovet; and R6: 14% CP, 2400 kcal/kg DE + 0,5 % Biovet. Results showed that body weight gain, feed consumption, and conversion were similar to rabbits given biovet supplement in low quality diet
Pengaruh Penambahan Biovet dalam Ransum dengan Berbagai Kandungan Protein-Energi terhadap Pertumbuhan Anak Kelinci Rex
An experiment was conducted to study the effect of Biovet supplement in diets of different protein-energy to weight gain of Rex rabbit kit. The experiment used 112 kit of 28 Rex Rabbits at PT Fiva Bandung Rabitry, Pangkalan village, Sub districk Gambung-Ciwidey District Bandung in Completely Randomized Design 7 treatments and 4 replications. The treatments were: R0: 18% CP and 2750 kcal/kg; DE R1: 16% CP, 2500 kcal/kg DE + 0% Biovet; R2: 16% CP, 2500 kcal/kg DE + 0,1% Biovet; R3: 16% CP, 2500 kcal/kg DE + 0,5% Biovet; R4: 14% CP, 2400 kcal/kg DE + 0% Biovet; R5: 14% CP, 2400 kcal/kg DE + 0,1% Biovet; and R6: 14% CP, 2400 kcal/kg DE + 0,5 % Biovet. Results showed that body weight gain, feed consumption, and conversion were similar to rabbits given biovet supplement in low quality diet.Β Key words: rabbit, biovet, protein-energ
Performa Hibrida Kelinci Hyla dan Hycole
Penelitian ini bertujuan melakukan karakterisasi produksi dan reproduksi kelinci hibrida Hyla (CABCCD), hibrida Hycole (PAPB) dan NZW (NN). Penelitian dilakukan di laboratorium ternak kelinci di Balai Penelitian Ternak. Kelinci hibrida Hycole (PAPB), kelinci hibrida Hyla (CABCCD) dan NZW (NN) yang digunakan masing-masing sejumlah 30 ekor betina dan 6 ekor jantan. Peubah yang diamati adalah performa induk (reproduksi induk dan bobot induk mingguan) dan performa anak (pertumbuhan mingguan sampai berumur 20 minggu). Data dianalisis menggunakan model linear umum bantuan program SAS. Produktivitas induk kelinci hibrida tidak berbeda (P>0.05) dengan parent stock, pertumbuhan anak kelinci hibrida Hyla sama dengan parent stock, kelinci hibrida Hycole pada masa menyusui (umur 0-6 minggu) lebih rendah dibandingkan parent stock (
Digestibilidade do bagaço de cana-de-açúcar tratado com hidróxido de sódio em dietas para coelhos em crescimento
Polymer ultrapermeability from the inefficient packing of 2D chains
The promise of ultrapermeable polymers, such as poly(trimethylsilylpropyne) (PTMSP), for reducing the size and increasing the efficiency of membranes for gas separations remains unfulfilled due to their poor selectivity. We report an ultrapermeable polymer of intrinsic microporosity (PIM-TMN-Trip) that is substantially more selective than PTMSP. From molecular simulations and experimental measurement we find that the inefficient packing of the two-dimensional (2D) chains of PIM-TMN-Trip generates a high concentration of both small (<0.7βnm) and large (0.7β1.0βnm) micropores, the former enhancing selectivity and the latter permeability. Gas permeability data for PIM-TMN-Trip surpass the 2008 Robeson upper bounds for O2/N2, H2/N2, CO2/N2, H2/CH4 and CO2/CH4, with the potential for biogas purification and carbon capture demonstrated for relevant gas mixtures. Comparisons between PIM-TMN-Trip and structurally similar polymers with three-dimensional (3D) contorted chains confirm that its additional intrinsic microporosity is generated from the awkward packing of its 2D polymer chains in a 3D amorphous solid. This strategy of shape-directed packing of chains of microporous polymers may be applied to other rigid polymers for gas separations
Genetic factors associated with patient-specific warfarin dose in ethnic Indonesians
<p>Abstract</p> <p>Background</p> <p><it>CYP2C9 </it>and <it>VKORC1 </it>are two major genetic factors associated with inter-individual variability in warfarin dose. Additionally, genes in the warfarin metabolism pathway have also been associated with dose variance. We analyzed Single Nucleotide Polymorphisms (SNPs) in these genes to identify genetic factors that might confer warfarin sensitivity in Indonesian patients.</p> <p>Methods</p> <p>Direct sequencing method was used to identify SNPs in <it>CYP2C9, VKORC1, CYP4F2, EPHX1, PROC </it>and <it>GGCX </it>genes in warfarin-treated patients. Multiple linear regressions were performed to model the relationship warfarin daily dose requirement with genetic and non-genetic variables measured and used to develop a novel algorithm for warfarin dosing.</p> <p>Results</p> <p>From the 40 SNPs analyzed, <it>CYP2C9 </it>rs17847036 and <it>VKORC1 </it>rs9923231 showed significant association with warfarin sensitivity. In our study population, no significant correlation could be detected between <it>CYP2C9*3, CYP2C9C</it>-65 (rs9332127), <it>CYP4F2 </it>rs2108622, <it>GGCX </it>rs12714145, <it>EPHX1 </it>rs4653436 and <it>PROC </it>rs1799809 with warfarin sensitivity.</p> <p>Conclusions</p> <p><it>VKORC1 </it>rs9923231 AA and <it>CYP2C9 </it>rs17847036 GG genotypes were associated with low dosage requirements of most patients (2.05 Β± 0.77 mg/day and 2.09 Β± 0.70 mg/day, respectively). <it>CYP2C9 </it>and <it>VKORC1 </it>genetic variants as well as non-genetic factors such as age, body weight and body height account for 15.4% of variance in warfarin dose among our study population. Additional analysis of this combination could allow for personalized warfarin treatment in ethnic Indonesians.</p
The HLH-6 Transcription Factor Regulates C. elegans Pharyngeal Gland Development and Function
The Caenorhabditis elegans pharynx (or foregut) functions as a pump that draws in food (bacteria) from the environment. While the βorgan identity factorβ PHA-4 is critical for formation of the C. elegans pharynx as a whole, little is known about the specification of distinct cell types within the pharynx. Here, we use a combination of bioinformatics, molecular biology, and genetics to identify a helix-loop-helix transcription factor (HLH-6) as a critical regulator of pharyngeal gland development. HLH-6 is required for expression of a number of gland-specific genes, acting through a discrete cis-regulatory element named PGM1 (Pharyngeal Gland Motif 1). hlh-6 mutants exhibit a frequent loss of a subset of glands, while the remaining glands have impaired activity, indicating a role for hlh-6 in both gland development and function. Interestingly, hlh-6 mutants are also feeding defective, ascribing a biological function for the glands. Pharyngeal pumping in hlh-6 mutants is normal, but hlh-6 mutants lack expression of a class of mucin-related proteins that are normally secreted by pharyngeal glands and line the pharyngeal cuticle. An interesting possibility is that one function of pharyngeal glands is to secrete a pharyngeal lining that ensures efficient transport of food along the pharyngeal lumen
Lamin A Rod Domain Mutants Target Heterochromatin Protein 1Ξ± and Ξ² for Proteasomal Degradation by Activation of F-Box Protein, FBXW10
Lamins are major structural proteins of the nucleus and contribute to the organization of various nuclear functions. Mutations in the human lamin A gene cause a number of highly degenerative diseases, collectively termed as laminopathies. Cells expressing lamin mutations exhibit abnormal nuclear morphology and altered heterochromatin organization; however, the mechanisms responsible for these defects are not well understood.The lamin A rod domain mutants G232E, Q294P and R386K are either diffusely distributed or form large aggregates in the nucleoplasm, resulting in aberrant nuclear morphology in various cell types. We examined the effects of these lamin mutants on the distribution of heterochromatin protein 1 (HP1) isoforms. HeLa cells expressing these mutants showed a heterogeneous pattern of HP1alpha and beta depletion but without altering HP1gamma levels. Changes in HP1alpha and beta were not observed in cells expressing wild-type lamin A or mutant R482L, which assembled normally at the nuclear rim. Treatment with proteasomal inhibitors led to restoration of levels of HP1 isoforms and also resulted in stable association of lamin mutants with the nuclear periphery, rim localization of the inner nuclear membrane lamin-binding protein emerin and partial improvement of nuclear morphology. A comparison of the stability of HP1 isoforms indicated that HP1alpha and beta displayed increased turnover and higher basal levels of ubiquitination than HP1gamma. Transcript analysis of components of the ubiquitination pathway showed that a specific F-box protein, FBXW10 was induced several-fold in cells expressing lamin mutants. Importantly, ectopic expression of FBXW10 in HeLa cells led to depletion of HP1alpha and beta without alteration of HP1gamma levels.Mislocalized lamins can induce ubiquitin-mediated proteasomal degradation of certain HP1 isoforms by activation of FBXW10, a member of the F-box family of proteins that is involved in E3 ubiquitin ligase activity
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