Genome Wide Analysis of Inbred Mouse Lines Identifies a Locus Containing Ppar-γ as Contributing to Enhanced Malaria Survival

The genetic background of a patient determines in part if a person develops a mild form of malaria and recovers, or develops a severe form and dies. We have used a mouse model to detect genes involved in the resistance or susceptibility to Plasmodium berghei malaria infection. To this end we first characterized 32 different mouse strains infected with P. berghei and identified survival as the best trait to discriminate between the strains. We found a locus on chromosome 6 by linking the survival phenotypes of the mouse strains to their genetic variations using genome wide analyses such as haplotype associated mapping and the efficient mixed-model for association. This new locus involved in malaria resistance contains only two genes and confirms the importance of Ppar-γ in malaria infection

How Much Do You Suffer? The Performativity of Scientific Scales of Work-Related Suffering

International audienceBased on a Foucauldian conception of knowledge, this research analyzes seven scales for measuring work-related suffering; scales commonly used in surveys conducted in organizations, and which perform a certain conception of the suffering subject and his/her environment. This analysis shows that these instruments construct the individual as a reflexive subject, as someone capable of accounting for his state and environment; but that, first of all individuals are not envisaged as actors in this environment and second of all, that the latter is limited to the immediate working environment. Consequently, the strategic, economic, sociological or ideological dimensions of this environment cannot be questioned. In this regard, our study suggests that research should be conducted on the so far neglected question of the limitations of those measuring instruments in terms of action and reflection