209 research outputs found
Subaru FOCAS Spectroscopic Observations of High-Redshift Supernovae
We present spectra of high-redshift supernovae (SNe) that were taken with the
Subaru low resolution optical spectrograph, FOCAS. These SNe were found in SN
surveys with Suprime-Cam on Subaru, the CFH12k camera on the
Canada-France-Hawaii Telescope (CFHT), and the Advanced Camera for Surveys
(ACS) on the Hubble Space Telescope (HST). These SN surveys specifically
targeted z>1 Type Ia supernovae (SNe Ia). From the spectra of 39 candidates, we
obtain redshifts for 32 candidates and spectroscopically identify 7 active
candidates as probable SNe Ia, including one at z=1.35, which is the most
distant SN Ia to be spectroscopically confirmed with a ground-based telescope.
An additional 4 candidates are identified as likely SNe Ia from the
spectrophotometric properties of their host galaxies. Seven candidates are not
SNe Ia, either being SNe of another type or active galactic nuclei. When SNe Ia
are observed within a week of maximum light, we find that we can
spectroscopically identify most of them up to z=1.1. Beyond this redshift, very
few candidates were spectroscopically identified as SNe Ia. The current
generation of super red-sensitive, fringe-free CCDs will push this redshift
limit higher.Comment: 19 pages, 26 figures. PASJ in press. see
http://www.supernova.lbl.gov/2009ClusterSurvey/ for additional information
pertaining to the HST Cluster SN Surve
Successful Small Intestine Colonization of Adult Mice by Vibrio cholerae Requires Ketamine Anesthesia and Accessory Toxins
Vibrio cholerae colonizes the small intestine of adult C57BL/6 mice. In this study, the physical and genetic parameters that facilitate this colonization were investigated. Successful colonization was found to depend upon anesthesia with ketamine-xylazine and neutralization of stomach acid with sodium bicarbonate, but not streptomycin treatment. A variety of common mouse strains were colonized by O1, O139, and non-O1/non-O139 strains. All combinations of mutants in the genes for hemolysin, the multifunctional, autoprocessing RTX toxin (MARTX), and hemagglutinin/protease were assessed, and it was found that hemolysin and MARTX are each sufficient for colonization after a low dose infection. Overall, this study suggests that, after intragastric inoculation, V. cholerae encounters barriers to infection including an acidic environment and an immediate immune response that is circumvented by sodium bicarbonate and the anti-inflammatory effects of ketamine-xylazine. After initial adherence in the small intestine, the bacteria are subjected to additional clearance mechanisms that are evaded by the independent toxic action of hemolysin or MARTX. Once colonization is established, it is suggested that, in humans, these now persisting bacteria initiate synthesis of the major virulence factors to cause cholera disease. This adult mouse model of intestinal V. cholerae infection, now well-characterized and fully optimized, should serve as a valuable tool for studies of pathogenesis and testing vaccine efficacy
Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation
We conducted a genome-wide association study (GWAS) on multiple sclerosis (MS) susceptibility in German cohorts with 4888 cases and 10,395 controls. In addition to associations within the major histocompatibility complex (MHC) region, 15 non-MHC loci reached genome-wide significance. Four of these loci are novel MS susceptibility loci. They map to the genes L3MBTL3, MAZ, ERG, and SHMT1. The lead variant at SHMT1 was replicated in an independent Sardinian cohort. Products of the genes L3MBTL3, MAZ, and ERG play important roles in immune cell regulation. SHMT1 encodes a serine hydroxymethyltransferase catalyzing the transfer of a carbon unit to the folate cycle. This reaction is required for regulation of methylation homeostasis, which is important for establishment and maintenance of epigenetic signatures. Our GWAS approach in a defined population with limited genetic substructure detected associations not found in larger, more heterogeneous cohorts, thus providing new clues regarding MS pathogenesis
Hypernovae and Other Black-Hole-Forming Supernovae
During the last few years, a number of exceptional core-collapse supernovae
(SNe) have been discovered. Their kinetic energy of the explosions are larger
by more than an order of magnitude than the typical values for this type of
SNe, so that these SNe have been called `Hypernovae'. We first describe how the
basic properties of hypernovae can be derived from observations and modeling.
These hypernovae seem to come from rather massive stars, thus forming black
holes. On the other hand, there are some examples of massive SNe with only a
small kinetic energy. We suggest that stars with non-rotating black holes are
likely to collapse "quietly" ejecting a small amount of heavy elements (Faint
supernovae). In contrast, stars with rotating black holes are likely to give
rise to very energetic supernovae (Hypernovae). We present distinct
nucleosynthesis features of these two types of "black-hole-forming" supernovae.
Hypernova nucleosynthesis is characterized by larger abundance ratios
(Zn,Co,V,Ti)/Fe and smaller (Mn,Cr)/Fe. Nucleosynthesis in Faint supernovae is
characterized by a large amount of fall-back. We show that the abundance
pattern of the most Fe deficient star, HE0107-5240, and other extremely
metal-poor carbon-rich stars are in good accord with those of
black-hole-forming supernovae, but not pair-instability supernovae. This
suggests that black-hole-forming supernovae made important contributions to the
early Galactic (and cosmic) chemical evolution.Comment: 49 pages, to be published in "Stellar Collapse" (Astrophysics and
Space Science; Kluwer) ed. C. L. Fryer (2003
Constraining dust and color variations of high-z SNe using NICMOS on Hubble Space Telescope
We present data from the Supernova Cosmology Project for five high redshift
Type Ia supernovae (SNe Ia) that were obtained using the NICMOS infrared camera
on the Hubble Space Telescope. We add two SNe from this sample to a rest-frame
I-band Hubble diagram, doubling the number of high redshift supernovae on this
diagram. This I-band Hubble diagram is consistent with a flat universe
(Omega_Matter, Omega_Lambda= 0.29, 0.71). A homogeneous distribution of large
grain dust in the intergalactic medium (replenishing dust) is incompatible with
the data and is excluded at the 5 sigma confidence level, if the SN host galaxy
reddening is corrected assuming R_V=1.75. We use both optical and infrared
observations to compare photometric properties of distant SNe Ia with those of
nearby objects. We find generally good agreement with the expected color
evolution for all SNe except the highest redshift SN in our sample (SN 1997ek
at z=0.863) which shows a peculiar color behavior. We also present spectra
obtained from ground based telescopes for type identification and determination
of redshift.Comment: 30 pages, 10 figures; accepted for publication in ApJ; v2: revised to
match the version in the journa
Family History of Alcoholism and Childhood Adversity: Joint Effects on Alcohol Consumption and Dependence
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65494/1/j.1530-0277.1994.tb00085.x.pd
Interfacial chemistry in the electrocatalytic hydrogenation of CO2 over C-Supported Cu-Based systems
Operando soft and hard X-ray spectroscopic techniques were used in combination with plane-wave density functional theory (DFT) simulations to rationalize the enhanced activities of Zn-containing Cu nanostructured electrocatalysts in the electrocatalytic CO2 hydrogenation reaction. We show that at a potential for CO2 hydrogenation, Zn is alloyed with Cu in the bulk of the nanoparticles with no metallic Zn segregated; at the interface, low reducible Cu(I)–O species are consumed. Additional spectroscopic features are observed, which are identified as various surface Cu(I) ligated species; these respond to the potential, revealing characteristic interfacial dynamics. Similar behavior was observed for the Fe–Cu system in its active state, confirming the general validity of this mechanism; however, the performance of this system deteriorates after successive applied cathodic potentials, as the hydrogen evolution reaction then becomes the main reaction pathway. In contrast to an active system, Cu(I)–O is now consumed at cathodic potentials and not reversibly reformed when the voltage is allowed to equilibrate at the open-circuit voltage; rather, only the oxidation to Cu(II) is observed. We show that the Cu–Zn system represents the optimal active ensembles with stabilized Cu(I)–O; DFT simulations rationalize this observation by indicating that Cu–Zn–O neighboring atoms are able to activate CO2, whereas Cu–Cu sites provide the supply of H atoms for the hydrogenation reaction. Our results demonstrate an electronic effect exerted by the heterometal, which depends on its intimate distribution within the Cu phase and confirms the general validity of these mechanistic insights for future electrocatalyst design strategies
Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol
The presence of Fc-receptor-blocking factors in the sera of normal and insulin-dependent diabetic pregnant women was investigated by means of an antibody-dependent cell-mediated cytotoxicity assay. Sera from normal pregnant women induced a significant depression of antibody dependent cell-mediated cytotoxicity when compared with sera from normal and diabetic non-pregnant women (p less than 0.0001; p less than 0.002, respectively). The effect of sera from diabetic pregnant women, however, was not different from that observed with sera from normal and diabetic non-pregnant women. Thus, we confirm the presence of Fc-receptor-blocking factors in the sera of normal pregnant women. The higher cytotoxicity levels measured in the presence of sera from pregnant women with insulin-dependent diabetes suggests that the titres of such factors are reduced in this conditio
Bat Eyes Have Ultraviolet-Sensitive Cone Photoreceptors
Mammalian retinae have rod photoreceptors for night vision and cone photoreceptors for daylight and colour vision. For colour discrimination, most mammals possess two cone populations with two visual pigments (opsins) that have absorption maxima at short wavelengths (blue or ultraviolet light) and long wavelengths (green or red light). Microchiropteran bats, which use echolocation to navigate and forage in complete darkness, have long been considered to have pure rod retinae. Here we use opsin immunohistochemistry to show that two phyllostomid microbats, Glossophaga soricina and Carollia perspicillata, possess a significant population of cones and express two cone opsins, a shortwave-sensitive (S) opsin and a longwave-sensitive (L) opsin. A substantial population of cones expresses S opsin exclusively, whereas the other cones mostly coexpress L and S opsin. S opsin gene analysis suggests ultraviolet (UV, wavelengths <400 nm) sensitivity, and corneal electroretinogram recordings reveal an elevated sensitivity to UV light which is mediated by an S cone visual pigment. Therefore bats have retained the ancestral UV tuning of the S cone pigment. We conclude that bats have the prerequisite for daylight vision, dichromatic colour vision, and UV vision. For bats, the UV-sensitive cones may be advantageous for visual orientation at twilight, predator avoidance, and detection of UV-reflecting flowers for those that feed on nectar
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