170 research outputs found
Dark Matter signals from Draco and Willman 1: Prospects for MAGIC II and CTA
The next generation of ground-based Imaging Air Cherenkov Telescopes (IACTs)
will play an important role in indirect dark matter searches. In this article,
we consider two particularly promising candidate sources for dark matter
annihilation signals, the nearby dwarf galaxies Draco and Willman 1, and study
the prospects of detecting such a signal for the soon-operating MAGIC II
telescope system as well as for the planned installation of CTA, taking special
care of describing the experimental features that affect the detectional
prospects. For the first time in such a study, we fully take into account the
effect of internal bremsstrahlung, which has recently been shown to
considerably enhance, in some cases, the gamma-ray flux at the high energies
where Atmospheric Cherenkov Telescopes operate, thus leading to significantly
harder annihilation spectra than traditionally considered. While the detection
of the spectral features introduced by internal bremsstrahlung would constitute
a smoking gun signature for dark matter annihilation, we find that for most
models the overall flux still remains at a level that will be challenging to
detect unless one adopts rather (though by no means overly) optimistic
astrophysical assumptions about the distribution of dark matter in the dwarfs.Comment: 10 pages, 4 figures, minor changes, matches the published version
(JCAP
Array tomography: Characterizing FAC-sorted populations of zebrafish immune cells by their 3D ultrastructure
For 3D reconstructions of whole immune cells from zebrafish, isolated from adult animals by FAC-sorting we employed array tomography on hundreds of serial sections deposited on silicon wafers. Image stacks were either recorded manually or automatically with the newly released ZEISS Atlas 5 Array Tomography platform on a Zeiss FEGSEM. To characterize different populations of immune cells, organelle inventories were created by segmenting individual cells. In addition, arrays were used for quantification of cell populations with respect to the various cell types they contained. The detection of immunological synapses in cocultures of cell populations from thymus or WKM with cancer cells helped to identify the cytotoxic nature of these cells. Our results demonstrate the practicality and benefit of AT for high-throughput ultrastructural imaging of substantial volumes. LAY DESCRIPTION: To look at immune cells from zebrafish we employed array tomography, a technique where arrays of serial sections deposited on solid substrates are used for imaging. Cell populations were isolated from the different organs of zebrafish involved in haematopoiesis, the production of blood cells. They were chemically fixed and centrifuged to concentrate them in a pellet that was then dehydrated and embedded in resin. Using a custom-built handling device it was possible to place hundreds of serial sections on silicon wafers as well ordered arrays. To image a whole cell at a resolution that would allow identifying all the organelles (i.e. compartments surrounded by membranes) inside the cell, stacks of usually 50–100 images were recorded in a scanning electron microscope (SEM). This recording was either done manually or automatically using the newly released Atlas Array Tomography platform on a ZEISS SEM. For the imaging of the sections a pixel size of about 5 nm was chosen, which defines membrane boundaries very well and allows segmentation of the membrane topology. After alignment of the images, cellular components were segmented to locate the individual organelles within the 3D reconstruction of the whole cell and also to create an inventory of organelles. Based on their morphologies we could identify specific cell types in the different hematopoietic organs. We could also quantify the proportion of each cell type in the whole population isolated from a given organ. Some of these specific cells from zebrafish were grown in a culture dish together with human cancer cells. By time-lapse light microscopy we observed that the fish cells attacked the cancer cells and killed them. From this we concluded that these cells must be similar to the cytotoxic cells from humans that play an important role in defence against spontaneously arising cancer cells in our bodies. They form special structures, called immunological synapses that we could also identify on our arrays and reconstruct in 3D. This is the first time the potential of zebrafish immune cells to form immunological synapses has been demonstrated. Our study is a good example for the practicality and benefit of array tomography in high-throughput ultrastructure imaging of substantial volumes, applicable to many areas of cell and developmental biology
Quintessence from Shape Moduli
We show that shape moduli in sub-millimeter extra dimensional scenarios,
addressing the gauge hierarchy problem, can dominate the energy density of the
universe today. In our scenario, the volume of the extra dimensions is
stabilized at a sufficiently high scale to avoid conflicts with nucleosynthesis
and solar-system precision gravity experiments, while the shape moduli remain
light but couple extremely weakly to brane-localized matter and easily avoid
these bounds. Nonlocal effects in the bulk of the extra dimension generate a
potential for the shape moduli. The potential has the right form and order of
magnitude to account for the present day cosmic acceleration, in a way
analogous to models of quintessence as a pseudo Nambu-Goldstone boson.Comment: 8 pages, 1 figur
Multi-wavelength interferometry of evolved stars using VLTI and VLBA
We report on our project of coordinated VLTI/VLBA observations of the
atmospheres and circumstellar environments of evolved stars. We illustrate in
general the potential of interferometric measurements to study stellar
atmospheres and envelopes, and demonstrate in particular the advantages of a
coordinated multi-wavelength approach including near/mid-infrared as well as
radio interferometry. We have so far made use of VLTI observations of the near-
and mid-infrared stellar sizes and of concurrent VLBA observations of the SiO
maser emission. To date, this project includes studies of the Mira stars S Ori
and RR Aql as well as of the supergiant AH Sco. These sources all show strong
silicate emission features in their mid-infrared spectra. In addition, they
each have relatively strong SiO maser emission. The results from our first
epochs of S Ori measurements have recently been published and the main results
are reviewed here. The S Ori maser ring is found to lie at a mean distance of
about 2 stellar radii, a result that is virtually free of the usual uncertainty
inherent in comparing observations of variable stars widely separated in time
and stellar phase. We discuss the status of our more recent S Ori, RR Aql, and
AH Sco observations, and present an outlook on the continuation of our project.Comment: 9 pages, to appear in the proceedings of the ESO workshop "The Power
of Optical/IR Interferometry: Recent Scientific Results and 2nd Generation
VLTI Instrumentation", ESO Astrophysics Symposi
Development and Validation of a Tokamak Skin Effect Transformer model
A control oriented, lumped parameter model for the tokamak transformer
including the slow flux penetration in the plasma (skin effect transformer
model) is presented. The model does not require detailed or explicit
information about plasma profiles or geometry. Instead, this information is
lumped in system variables, parameters and inputs. The model has an exact
mathematical structure built from energy and flux conservation theorems,
predicting the evolution and non linear interaction of the plasma current and
internal inductance as functions of the primary coil currents, plasma
resistance, non-inductive current drive and the loop voltage at a specific
location inside the plasma (equilibrium loop voltage). Loop voltage profile in
the plasma is substituted by a three-point discretization, and ordinary
differential equations are used to predict the equilibrium loop voltage as
function of the boundary and resistive loop voltages. This provides a model for
equilibrium loop voltage evolution, which is reminiscent of the skin effect.
The order and parameters of this differential equation are determined
empirically using system identification techniques. Fast plasma current
modulation experiments with Random Binary Signals (RBS) have been conducted in
the TCV tokamak to generate the required data for the analysis. Plasma current
was modulated in Ohmic conditions between 200kA and 300kA with 30ms rise time,
several times faster than its time constant L/R\approx200ms. The model explains
the most salient features of the plasma current transients without requiring
detailed or explicit information about resistivity profiles. This proves that
lumped parameter modeling approach can be used to predict the time evolution of
bulk plasma properties such as plasma inductance or current with reasonable
accuracy; at least in Ohmic conditions without external heating and current
drive sources
Nucleon charge exchange on the deuteron: A critical review
The existing experimental data on the d(n,p)nn and d(p,n)pp cross sections in
the forward direction are reviewed in terms of the Dean sum rule. It is shown
that the measurement of the ratio of the charge exchange on the deuteron to
that on the proton might, if taken together with other experimental data, allow
a direct construction of the np -> np scattering amplitude in the backward
direction with few ambiguities.Comment: 7 pages with 3 figure
Characterization of optical properties and surface roughness profiles: The Casimir force between real materials
The Lifshitz theory provides a method to calculate the Casimir force between
two flat plates if the frequency dependent dielectric function of the plates is
known. In reality any plate is rough and its optical properties are known only
to some degree. For high precision experiments the plates must be carefully
characterized otherwise the experimental result cannot be compared with the
theory or with other experiments. In this chapter we explain why optical
properties of interacting materials are important for the Casimir force, how
they can be measured, and how one can calculate the force using these
properties. The surface roughness can be characterized, for example, with the
atomic force microscope images. We introduce the main characteristics of a
rough surface that can be extracted from these images, and explain how one can
use them to calculate the roughness correction to the force. At small
separations this correction becomes large as our experiments show. Finally we
discuss the distance upon contact separating two rough surfaces, and explain
the importance of this parameter for determination of the absolute separation
between bodies.}Comment: 33 pages, 14 figures, to appear in Springer Lecture Notes in Physics,
Volume on Casimir Physics, edited by Diego Dalvit, Peter Milonni, David
Roberts, and Felipe da Ros
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